Impact of smoking cessation on coronary vasomotor response assessed with O-15 labeled water and PET in healthy young smokers

Morita, Koichi; Tsukamoto, Takahiro; Naya, Masanao; Noriyasu, Kazuyuki; Mabichi, M.; Kageyama, Hiroyuki; Tamaki, Nagara

doi:10.1016/j.nuclcard.2004.12.240

Cited by 29 publications

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“…Smoking is known to cause increased fibrinogen concentrations and platelet aggregability, along with impaired fibrinolytic activity, decreased coronary flow reserve, and increased vasospasm. 19,20 Result of the Bogalusa Heart Study have showed that the extent of fatty-streak lesions in the coronary arteriesof young adults was higher in smokers than in nonsmokers. 21 The risk of CAD decreases after quitting smoking, and its benefit is correlated with amount smoked.…”

Section: -10% Of Myocardial Infarctions (Mi) Occur In Patients Youngermentioning

confidence: 99%

Acute ST-Elevation Myocardial Infarction in Young in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

et al. 2017

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Section: -10% Of Myocardial Infarctions (Mi) Occur In Patients Youngermentioning

confidence: 99%

Acute ST-Elevation Myocardial Infarction in Young in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

et al. 2017

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“…Wong et al (2005) associated current cigarette smoking (OR = 3.08; 95%CI = 1.47-6.47) with cardiovascular diseases using data pooled from the Atherosclerosis Risk in Communities Study (N = 12,642; mean age, 60 years) and the Cardiovascular Health Study (N = 2824; mean age, 79 years). Recent research has indicated that cigarette smoking is related to abnormal peripheral and coronary vascular vasomotion (Morita et al, 2006). The results of another report showed that coronary vascular endothelial dysfunction was caused by chronic smoking in smokers without epicardial CAS and that coronary endothelial dysfunction may be reversible within 1 month after smoking cessation in healthy young smokers (Wilson et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population

Li²,

Liu³

et al. 2013

Genet. Mol. Res.

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“…32) Following smoking cessation, coronary endothelial vasomotor abnormality recovers in healthy young smokers, 33) although not in middle-aged smokers or long-term smokers. 30) In patients with variant angina, smoking cessation also improves short-term prognosis, 34) which may be brought on by coronary endothelium-mediated vasodilatation and vascular smooth muscle relaxation.…”

Section: Discussionmentioning

confidence: 99%

Impact of Smoking on Coronary Microcirculatory Resistance in Patients With Coronary Artery Disease

et al. 2015

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SummaryThe aim of this study was to investigate the relationship between coronary microvascular function and smoking using the 3 parameters fractional flow reserve (FFR), coronary flow reserve (CFR thermo ), and index of microcirculatory resistance (IMR) in patients with coronary artery disease (CAD). A total of 97 CAD patients with 148 intermediate stenotic lesions were divided into two groups: current and former smokers (Smokers: n = 54), and those who had never smoked (Non-smokers: n = 43). Coronary physiology measurements were made following coronary angiography at rest and during hyperemia induced with intravenous adenosine triphosphate. If a patient had several intermediate lesions, the lesion producing the largest IMR value and minimum FFR myo and CFR thermo value was selected. Averaged over all patients, the FFR myo , CFR thermo , and IMR values were 0.86 ± 0.10, 2.66 ± 1.50, and 20.8 ± 10.7, respectively. There was no significant correlation between FFR myo and IMR. There were no significant differences between smokers and non-smokers in FFR myo value ( perfusion is dependent on both epicardial and microvascular resistance. 1) An increased microcirculatory resistance indicates the presence of coronary microvascular dysfunction (CMVD), a term introduced to describe abnormalities in the regulation of microvascular blood flow. CMVD has been found to play an important role in determining ischemic threshold 2) and to be independent of epicardial stenosis severity.3) Smoking is known to be associated with the development of epicardial atherosclerosis and impairment of coronary endothelial function. [4][5][6] However, the effects of smoking on coronary microvascular function are unknown.Recently, a parameter called the index of microcirculatory resistance (IMR) was proposed for evaluating coronary microvascular function. The advantage of this parameter is that it could be calculated from values obtained using a coronary temperature and pressure sensing guidewire. 7) IMR has been found to be a reproducible index and to be independent of epicardial stenosis severity.7-10) The aim of this study was to investigate the relationship between microvascular function and smoking in patients with CAD by comparing 3 coronary physiology parameters, fractional flow reserve (FFR), coronary flow reserve (CFR), and IMR, between patients with and without a smoking history. MethodsStudy population: A total of 97 patients with CAD who had 148 discrete intermediate grade stenotic lesions (40-70% diameter stenosis on visual assessment) and visited the Department of Cardiovascular Medicine, Kashiwa Municipal Hospital (Chiba, Japan) from August 2010 to August 2013 were retrospectively enrolled. To examine the relationship between coronary physiology and smoking, patients were divided into two groups based on smoking status; current and former smokers (smokers), and those who had never smoked (non-smokers). The exclusion criteria were 1) history of coronary artery bypass surgery; 2) history of myocardial infarction (MI); 3) recent MI,...

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Impact of smoking cessation on coronary vasomotor response assessed with O-15 labeled water and PET in healthy young smokers

Cited by 29 publications

References 0 publications

Acute ST-Elevation Myocardial Infarction in Young in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

Acute ST-Elevation Myocardial Infarction in Young in Shahid Gangalal National Heart Centre, Kathmandu, Nepal

KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population

Impact of Smoking on Coronary Microcirculatory Resistance in Patients With Coronary Artery Disease

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