Impact of Smoking Cessation on Periodontal Tissues

Duarte, Poliana Mendes; Nogueira, Cristiana Fernandes Plutarco; Silva, Sarah Monique; Pannuti, Cláudio Mendes; Schey, Karin; Miranda, Tamires Szeremeske

doi:10.1016/j.identj.2021.01.016

Cited by 16 publications

(9 citation statements)

References 48 publications

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“…Supporting this finding, a protective effect was found on all outcomes when the number of current smokers decreased in the DMS (adults) and SHIP cohorts. On the other hand, smoking cessation is known to reduce both periodontal disease severity and tooth loss (Leite et al, 2019; Duarte et al, 2021). Unfortunately, the information on the time of smoking cessation was not collected in our studies; hence we could not assess the influence of smoking cessation on the outcomes.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing tooth loss in European populations

Pitchika

Jordan²,

Norderyd

et al. 2022

J Clinic Periodontology

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Aim This study aimed to identify the factors influencing the changes in the number of teeth present and the number of healthy or filled surfaces between two time points. Materials and Methods Repeated cross‐sectional data from population‐based studies, namely the German Oral Health Studies (DMS‐III vs. DMS‐V), the Studies of Health in Pomerania (SHIP‐START‐0 vs. SHIP‐TREND‐0), and the Jönköping study (2003 vs. 2013), were analysed. Oaxaca decomposition models were constructed for the outcomes (number of teeth, number of healthy surfaces, and number of filled surfaces). Results The number of teeth increased between examinations (DMS: +2.26 [adults], +4.92 [seniors], SHIP: +1.67, Jönköping: +0.96). Improvements in education and dental awareness brought a positive change in all outcomes. An increase in powered toothbrushing and inter‐dental cleaning had a great impact in DMS (adults: +0.25 tooth, +0.78 healthy surface, +0.38 filled surface; seniors: +1.19 teeth, 5.79 healthy surfaces, +0.48 filled surface). Inter‐dental cleaning decreased by 4% between SHIP‐START‐0 and SHIP‐TREND‐0, which negatively affected the outcomes. Conclusions From this study, it can be concluded that education may be the most important factor having a direct and indirect effect on the outcomes. However, for better oral health, powered toothbrushing and inter‐dental cleaning should not be neglected.

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Section: Discussionmentioning

confidence: 99%

Factors influencing tooth loss in European populations

Pitchika

Jordan²,

Norderyd

et al. 2022

J Clinic Periodontology

View full text Add to dashboard Cite

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“…The decreased bleeding indicates an underlying disruption of the immune response, which may lead to the increased loss of attachment and alveolar bone ( 34 , 35 ). More importantly, smoking cessation seems to be favorable for the periodontium, which decreases the risk for the incidence and progression of periodontitis ( 36 , 37 ).…”

Section: Pathobiology Of Periodontal Diseasesmentioning

confidence: 99%

mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases

Jiang

Huang

et al. 2022

Front. Immunol.

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Periodontal disease results from the inflammatory infiltration by the microbial community which is marked through tooth mobility and alveolar bone resorption. The inflammation in periodontal disease is mediated by CD4+ T cells through cytokine secretion and osteoclastogenetic activity. Historically, the inflammatory model in periodontal disease is described through disruption of the balance between two subsets of T helper cells which are T-helper type 1 (Th1) and T-helper type 2 (Th2). However, more and more studies have found that apart from subsets of helper T cells, regulatory T-cells and Th17 cells are also involved in the pathogenesis of periodontal diseases. Growing evidence proves that helper T cells differentiation, activation, and subset determination are under the strong impact of mTOR signaling. mTOR signaling could promote Th1 and Th17 cell differentiation and inhibit Treg commitment through different mTOR complexes, therefore we anticipate a regulation effect of mTOR signaling on periodontal diseases by regulating CD4+ T cell subsets. This review aims to integrate the topical researches about the role of different types of Th cells in the pathogenesis of periodontal diseases, as well as the regulation of mTOR signaling in the specification and selection of Th cell commitment.

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“…Smoking also has a negative effect on the outcome of both non-surgical and surgical periodontal therapy: Current smokers exhibit poorer responses than former or never smokers [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Smoking cessation results in beneficial effects on periodontal status, and former smokers have the potential to experience periodontal stability similar to non-smokers [ 31 , 32 , 33 , 34 , 35 ]. The effects of diabetes mellitus (DM) span multiple organs throughout the entire body.…”

Section: Introductionmentioning

confidence: 99%

A Tale of Two Fimbriae: How Invasion of Dendritic Cells by Porphyromonas gingivalis Disrupts DC Maturation and Depolarizes the T-Cell-Mediated Immune Response

2022

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Porphyromonas gingivalis (P. gingivalis) is a unique pathogen implicated in severe forms of periodontitis (PD), a disease that affects around 50% of the US population. P. gingivalis is equipped with a plethora of virulence factors that it uses to exploit its environment and survive. These include distinct fimbrial adhesins that enable it to bind to other microbes, colonize inflamed tissues, acquire nutrients, and invade cells of the stroma and immune system. Most notable for this review is its ability to invade dendritic cells (DCs), which bridge the innate and adaptive immune systems. This invasion process is tightly linked to the bridging functions of resultant DCs, in that it can disable (or stimulate) the maturation function of DCs and cytokines that are secreted. Maturation molecules (e.g., MHCII, CD80/CD86, CD40) and inflammatory cytokines (e.g., IL-1b, TNFa, IL-6) are essential signals for antigen presentation and for proliferation of effector T-cells such as Th17 cells. In this regard, the ability of P. gingivalis to coordinately regulate its expression of major (fimA) and minor (mfa-1) fimbriae under different environmental influences becomes highly relevant. This review will, therefore, focus on the immunoregulatory role of P. gingivalis fimbriae in the invasion of DCs, intracellular signaling, and functional outcomes such as alveolar bone loss and immune senescence.

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Impact of Smoking Cessation on Periodontal Tissues

Cited by 16 publications

References 48 publications

Factors influencing tooth loss in European populations

Factors influencing tooth loss in European populations

mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases

A Tale of Two Fimbriae: How Invasion of Dendritic Cells by Porphyromonas gingivalis Disrupts DC Maturation and Depolarizes the T-Cell-Mediated Immune Response

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