Impact of small thrombus formation in restenotic bare-metal stent lesions associated with acute coronary syndrome: Identification by optical coherence tomography

Yamamoto, Masanori; Takano, Masamichi; Murakami, Daisuke; Inami, Toru; Kobayashi, Nobuaki; Shirakabe, Akihiro; Inami, Shigenobu; Okamatsu, Kentaro; Ohba, Takayoshi; Aoki, Satoshi; Seino, Yoshihiko; Mizuno, Kyoichi

doi:10.1016/j.ijcard.2009.12.027

Cited by 10 publications

(4 citation statements)

References 33 publications

(33 reference statements)

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“…The procedure requires anticoagulants, such as ethylene diamine tetraacetic acid (EDTA) or sodium citrate, for blood collection that may lead to artifacts, and this method ignores the influence of platelet-activating factors elicited by the vessel wall (6,7). These problems could be solved by noninvasive assessments of larger blood volumes in vivo; however, existing diagnostic techniques, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) can only detect fixed or slowly moving large (macro) clots and do not allow diagnosis of fast moving small micro-clots (9)(10)(11)(12)(13)(14)(15)(16). Fluorescent imaging can identify rolling clots in some experimental models (16); however, translation of this method to humans is problematic because of the toxicity of fluorescent tags, influence of autofluorescence background, and assessment of superficial microvessels only with slow flow velocity.…”

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confidence: 99%

In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts

et al. 2011

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Conventional photothermal (PT) and photoacousic (PA) imaging, spectroscopy, and cytometry are preferentially based on positive PT/PA effects, when signals are above background. Here, we introduce PT/PA technique based on detection of negative signals below background. Among various new applications, we propose label-free in vivo flow cytometry of circulating clots. No method has been developed for the early detection of clots of different compositions as a source of severe thromboembolisms including ischemia at strokes and myocardial dysfunction at heart attack. When a low-absorbing, platelet-rich clot passes a laser-irradiated vessel volume, a transient decrease in local absorption results in an ultrasharp negative PA hole in blood background. Using this phenomenon alone or in combination with positive contrasts, we demonstrated identification of white, red and mixed clots on a mouse model of myocardial infarction and human blood. The concentration and size of clots were measured with threshold down to few clots in the entire circulation with size as low as 20 µm. This multiparameter diagnostic platform using portable personal high-speed flow cytometer with negative dynamic contrast mode has potential to real-time defining risk factors for cardiovascular diseases, and for prognosis and prevention of stroke or use clot count as a marker of therapy efficacy. Possibility for label-free detection of platelets, leukocytes, tumor cells or targeting them by negative PA probes (e.g., nonabsorbing beads or bubbles) is also highlighted.

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confidence: 99%

In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts

et al. 2011

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“…The arterial injury from a stent implantation and the resulting neointimal proliferation may serve as a nidus for subsequent thrombus formation, resulting in an acute presentation. This has been shown by an elegant optical coherence tomography (OCT) study of a small thrombus formation adjacent to the narrowest lumen in a restenotic lesion contributing to the clinical presentation of ACS [18]. In addition, the ratio of the uncovered to total stent struts has been linked with the manifestation of an acute coronary syndrome after the DES implantation [19].…”

Section: Restenosismentioning

confidence: 97%

Acute myocardial infarction late following stent implantation: Incidence, mechanisms and clinical presentation

Alexopoulos

2011

International Journal of Cardiology

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“…However, it has recently been reported that chronic thrombosis and inflammation influence ISR after stent implantation [12,13]. Optical coherence tomography (OCT) and pathologic studies have shown that organized thrombus can be a component of restenosis in both BMS and DES [14].…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological characteristics of homogeneous and nonhomogeneous tissue of in-stent restenosis visualized by optical coherence tomography

Itoh

Fusazaki

Kimura

et al. 2015

Coronary Artery Disease

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Impact of small thrombus formation in restenotic bare-metal stent lesions associated with acute coronary syndrome: Identification by optical coherence tomography

Cited by 10 publications

References 33 publications

In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts

In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts

Acute myocardial infarction late following stent implantation: Incidence, mechanisms and clinical presentation

Clinical and pathological characteristics of homogeneous and nonhomogeneous tissue of in-stent restenosis visualized by optical coherence tomography

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