Impact of Sleepiness and Sleep Deficiency on Public Health—Utility of Biomarkers

Czeisler, Charles A.

doi:10.5664/jcsm.1340

Cited by 66 publications

(51 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fact that sleep-wake disruptions occur during confinement and isolation in some individuals more than others is consistent with increasing evidence that there are phenotypic and genotypic differences in vulnerability to both alterations of sleep and the resulting neurobehavioral consequences (31)(32)(33)(34)(35)(36)(37). This differential vulnerability has led to a search for predictive biomarkers of the effects of sleep loss (38), which would be useful for managing sleep-wake regulation during exploration spaceflight (39).…”

Section: Discussionmentioning

confidence: 86%

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

Basner

Dinges

Mollicone

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

148

View full text Add to dashboard Cite

The success of interplanetary human spaceflight will depend on many factors, including the behavioral activity levels, sleep, and circadian timing of crews exposed to prolonged microgravity and confinement. To address the effects of the latter, we used a highfidelity ground simulation of a Mars mission to objectively track sleep-wake dynamics in a multinational crew of six during 520 d of confined isolation. Measurements included continuous recordings of wrist actigraphy and light exposure (4.396 million min) and weekly computer-based neurobehavioral assessments (n = 888) to identify changes in the crew's activity levels, sleep quantity and quality, sleep-wake periodicity, vigilance performance, and workload throughout the record-long 17 mo of mission confinement. Actigraphy revealed that crew sedentariness increased across the mission as evident in decreased waking movement (i.e., hypokinesis) and increased sleep and rest times. Light exposure decreased during the mission. The majority of crewmembers also experienced one or more disturbances of sleep quality, vigilance deficits, or altered sleep-wake periodicity and timing, suggesting inadequate circadian entrainment. The results point to the need to identify markers of differential vulnerability to hypokinesis and sleepwake changes during the prolonged isolation of exploration spaceflight and the need to ensure maintenance of circadian entrainment, sleep quantity and quality, and optimal activity levels during exploration missions. Therefore, successful adaptation to such missions will require crew to transit in spacecraft and live in surface habitats that instantiate aspects of Earth's geophysical signals (appropriately timed light exposure, food intake, exercise) required for temporal organization and maintenance of human behavior.sleep-wake regulation | astronaut T he success of human interplanetary spaceflight, which is anticipated to be in this century, will depend on the ability of spacefarers to remain confined and isolated from Earth much longer than previous missions or simulations, while maintaining the intensity and timing of behavioral activity necessary to accomplish the mission and mitigate the effects of microgravity. A total of four people have spent >1 y in space, with the record of 437 consecutive days on the Mir space station set by Valery Polyakov. The longest Earth-based spaceflight simulation involved four Russians confined in connected hyperbaric chambers for 240 consecutive days. Antarctic winter-over missions have extended up to 363 d. Prediction of how prolonged confinement affects activity levels and sleep-wake dynamics of space explorers is needed to inform spacecraft habitability requirements, crew selection, and behavioral countermeasures during interplanetary missions (1-3). To address this need, we obtained objective neurobehavioral data on the activity patterns of a multinational, culturally diverse crew of six males with backgrounds in engineering, medicine, physiology, and space training, who participated in a high-fidelity g...

show abstract

Section: Discussionmentioning

confidence: 86%

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

Basner

Dinges

Mollicone

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

148

View full text Add to dashboard Cite

show abstract

“…They also set forth a challenge to develop an understanding of the mechanisms of the threat posed by sleep deficiency to health. 22 Sleep deficiency, as defined by Czeisler 23 is ''a deficit in the quantity or quality of sleep obtained versus the amount needed for optimal health, performance, and well being.'' Buxton and colleagues proposed specific sleep variables they believed best reflected this concept.…”

mentioning

confidence: 99%

Prevalence of Sleep Deficiency in Early Gestation and its Associations with Stress and Depressive Symptoms

Okun

Kline

Roberts

et al. 2013

Journal of Women's Health

View full text Add to dashboard Cite

Objective: Sleep deficiency is an emerging concept denoting a deficit in the quantity or quality of sleep. This may be particularly salient for pregnant women since they report considerable sleep complaints. Sleep deficiency is linked with morbidity, including degradations in psychosocial functioning, (e.g., depression and stress), which are recognized risk factors for adverse pregnancy outcomes. We sought to describe the frequency of sleep deficiency across early gestation (10-20 weeks) and whether sleep deficiency is associated with reports of more depressive symptoms and stress. Methods: Pregnant women (N = 160) with no self-reported sleep or psychological disorder provided sleep data collected via diary and actigraphy during early pregnancy: 10-12, 14-16, and 18-20 weeks' gestation. Sleep deficiency was defined as short sleep duration, insufficient sleep, or insomnia. Symptoms of depression and stress were collected at the same three time points. Linear mixed effects models were used to analyze the data.Results: Approximately 28%-38% met criteria for sleep deficiency for at least one time point in early gestation. Women who were sleep deficient across all time points reported more perceived stress than those who were not sleep deficient ( p < 0.01). Depressive symptoms were higher among women with diary-defined sleep deficiency across all time points ( p = 0.02). Discussion: Sleep deficiency is a useful concept to describe sleep recognized to be disturbed in pregnancy. Women with persistent sleep deficiency appear to be at greater risk for impairments in psychosocial functioning during early gestation. These associations are important since psychosocial functioning is a recognized correlate of adverse pregnancy outcomes. Sleep deficiency may be another important risk factor for adverse pregnancy outcomes.

show abstract

“…4,5,17,18 In the 3rd edition of the International Classifi cation of Sleep Disorders (ICSD-3), 19 insuffi cient sleep syndrome (ISS) was classifi ed as one of the central hyposomnolence disorders characterized by longer sleep durations on weekends BRIEF SUMMARY Current Knowledge/Study Rationale: Insuffi cient sleep syndrome (ISS) in young adults has become a problematic issue in modern Japanese society; however, neither the prevalence nor factors associated with the disorder have been completely examined. Sleep-wake pattern as well as sleep duration is associated with depression, hence it was hypothesized that habitual sleep pattern would have an impact on daytime function in ISS-affected persons.…”

Section: S C I E N T I F I C I N V E S T I G At I O N Smentioning

confidence: 99%

Prevalence and Correlates of Insufficient Sleep Syndrome in Japanese Young Adults: A Web-Based Cross-Sectional Study

Morita

Sasai-Sakuma

Asaoka

et al. 2015

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objectives: This study investigated the prevalence and risk factors of insuffi cient sleep syndrome (ISS), and factors associated with daytime dysfunction in the disorder in Japanese young adults. Methods: In this cross-sectional study, a web-based questionnaire survey was used to assess demographic variables, sleep habits and quality, depressive symptoms, and health-related quality of life (HRQOL) in 2,276 participants aged 20-25. Results: Eleven percent of participants were classifi ed as having ISS. Multiple logistic regression analysis revealed that the presence of ISS was signifi cantly associated with social status (student or full-time employee). The participants with ISS had signifi cantly higher depression scores and lower mental component summary scores than healthy sleepers.In the participants with ISS, a delayed sleep-wake schedule was extracted as a factor associated with worse mental component summary. Conclusions:Results indicate a relatively high proportion of Japanese young adults suffer from ISS, and that the condition is associated with a social status of student or full-time employee. Moreover, a delayed sleep-wake schedule may lead to further deterioration of mental HRQOL in ISS-affected persons. Keywords: insuffi cient sleep syndrome, young adults, healthrelated quality of life, depression, delayed sleep-wake schedule Citation: Morita Y, Sasai-Sakuma T, Asaoka S, Inoue Y. Prevalence and correlates of insuffi cient sleep syndrome in Japanese young adults: a web-based cross-sectional study.

show abstract

Impact of Sleepiness and Sleep Deficiency on Public Health—Utility of Biomarkers

Cited by 66 publications

References 32 publications

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing

Prevalence of Sleep Deficiency in Early Gestation and its Associations with Stress and Depressive Symptoms

Prevalence and Correlates of Insufficient Sleep Syndrome in Japanese Young Adults: A Web-Based Cross-Sectional Study

Contact Info

Product

Resources

About