Impact of sleep quality on the quality of life of patients with Parkinson’s disease: a questionnaire based study

Pandey, Shweta; Bajaj, Bhupender Kumar; Wadhwa, Ankur; Anand, Kuljeet Singh

doi:10.1016/j.clineuro.2016.06.014

Cited by 37 publications

(36 citation statements)

References 27 publications

(27 reference statements)

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“…Rapid eye movement (REM) sleep behavior disorder (RBD) was reported as a male-related symptom in PD; 33 , 46 – 48 some other sleep disturbances were found to be more severe among females. 34 , 49 We did not find any difference in sleep disturbance between males and females using the nonmotor items of the UPDRS. A more thorough assessment with a valid and specific tool such as polysomnography is required to investigate sexual dimorphism in sleep disorders in people with PD.…”

Section: Discussioncontrasting

confidence: 53%

Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Farhadi¹,

Vosoughi²,

Shahidi³

et al. 2017

NDT

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IntroductionSex-related differences in clinical manifestations and consequences of Parkinson’s disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD.Patients and methodsA comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD. In order to control for potential confounding variables, we applied Orthogonal Partial Least Squares – Discriminant Analysis (OPLS-DA) to explore the strength of each feature to discriminate male and female patients with PD.ResultsWhile no sex difference was found in the total Unified Parkinson’s Disease Rating Scale (UPDRS) score and cumulative daily dose of levodopa, females had significantly more severe anxiety (mean difference =2.2 [95% confidence interval, CI: 0.5–4.0], P=0.011), worse nutritional status (23.8 [standard deviation, SD =4.2] vs 25.8 [SD =2.6], P=0.003) and poorer QoL (28.3 [SD =15.7] vs 17.9 [SD =14.2], P<0.001). Based on multivariate discriminant analysis, emotional well-being, bodily discomfort, social support, mobility and communication domains of HRQoL, together with anxiety, depression and psychosocial functioning, were the strongest features with more severe/worse status in females after adjustment for potential statistical confounders.ConclusionOur study provides a comprehensive understanding of sexual dimorphism in PD. Anxiety, depression, specific domains of HRQoL (mobility, emotional well-being, social support and bodily discomfort) and psychosocial functioning were significantly worse in female individuals with PD. Sexual dimorphism in PD highlights the features that are more likely to be affected in each sex and should be specifically targeted when managing male and female individuals with PD.

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Section: Discussioncontrasting

confidence: 53%

Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Farhadi¹,

Vosoughi²,

Shahidi³

et al. 2017

NDT

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“…Parkinson disease (PD) is well known for its motor symptoms such as rigor, tremor, postural instability, and bradykinesia. However, there are also non-motor symptoms (NMS), which have a strong impact on quality of life (QoL), such as constipation, olfactory disturbances, and obsessional behavior [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. The economic burden for society is comparable to that of strokes or heart failures [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Mild Cognitive Impairment, Depression, and Anxiety on the Quality of Life of Patients with Parkinson Disease

Wiesli

Meyer

Fuhr

et al. 2017

Dement Geriatr Cogn Disord Extra

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Background: Neuropsychiatric symptoms (NPS) and mild cognitive impairment (MCI) are common in Parkinson disease (PD) and have a negative impact on the patient’s quality of life (QoL). We aim to describe the effect of NPS and MCI on each other and on QoL. Methods: Sixteen MCI and 37 non-MCI PD patients completed different self-assessment questionnaires including the Parkinson’s Disease Questionnaire (PDQ-39), the Beck Depression Inventory (BD), the Beck Anxiety Inventory (BAI), and the Self-Report Manic Inventory (SRMI). Linear regression with stepwise elimination was used to select the significant predictors of QoL and to control for confounding factors. Results: The significant linear regression model (R² = 0.68, p ≤ 0.01) revealed significant effects of MCI (p = 0.03), BDI (p ≤ 0.01), BAI (p ≤ 0.01), age (p = 0.03), a trend of SRMI (p = 0.06), and disease duration (p = 0.08) on QoL. Conclusions: MCI, anxiety, depression, and age decrease QoL in patients with PD. NPS has the main influence in the prediction of QoL in patients with PD, whereas MCI is only of minor importance.

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“…EDS in PD is associated with decreased health related quality of life (64, 65), worse cognitive impairment (66), worse motor and non-motor symptoms as well as increased medication wearing off (67, 68). In PD, depressive symptoms correlate significantly with EDS (27, 63).…”

Section: Introductionmentioning

confidence: 99%

Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

Gros

Videnović

2017

Curr Sleep Medicine Rep

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Purpose of review Sleep disorders are among the most challenging non-motor features of Parkinson’s disease (PD) and significantly affect quality of life. Research in this field has gained recent interest among clinicians and scientists and is rapidly evolving. This review is dedicated to sleep and circadian dysfunction associated with PD. Recent findings Most primary sleep disorders may co-exist with PD; majority of these disorders have unique features when expressed in the PD population. Summary We discuss the specific considerations related to the common sleep problems in Parkinson’s disease including insomnia, rapid eye movement sleep behavior disorder, restless legs syndrome, sleep disordered breathing, excessive daytime sleepiness and circadian rhythm disorders. Within each of these sleep disorders, we present updated definitions, epidemiology, etiology, diagnosis, clinical implications and management. Furthermore, areas of potential interest for further research are outlined.

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Impact of sleep quality on the quality of life of patients with Parkinson’s disease: a questionnaire based study

Cited by 37 publications

References 27 publications

Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Influence of Mild Cognitive Impairment, Depression, and Anxiety on the Quality of Life of Patients with Parkinson Disease

Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

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Impact of sleep quality on the quality of life of patients with Parkinson’s disease: a questionnaire based study

Cited by 37 publications

References 27 publications

Sexual dimorphism in Parkinson&rsquo;s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Sexual dimorphism in Parkinson&rsquo;s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Influence of Mild Cognitive Impairment, Depression, and Anxiety on the Quality of Life of Patients with Parkinson Disease

Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

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Product

Resources

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Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females