Impact of Sleep on Arrhythmogenesis

Verrier, Richard L.; Josephson, Mark E.

doi:10.1161/circep.109.867028

Cited by 70 publications

(45 citation statements)

References 94 publications

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“…Sudden cardiac death was witnessed (71) or judged by physician review (68,73,97) or an events committee (98,99). TWA detected with continuous 24-h ECG monitoring reflects the influences of daily activity, mental stress (22), sleep states (100), and sleep apnea (101). Results of these investigations support MMA analysis of TWA during the flow of routine clinical assessment.…”

Section: Clinical Utilitymentioning

confidence: 99%

Microvolt T-Wave Alternans

Verrier

Klingenheben

Malík

et al. 2011

Journal of the American College of Cardiology

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377

141

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This consensus guideline was prepared on behalf of the International Society for Holter and Noninvasive Electrocardiology and is cosponsored by the Japanese Circulation Society, the Computers in Cardiology Working Group on e-Cardiology of the European Society of Cardiology, and the European Cardiac Arrhythmia Society. It discusses the electrocardiographic phenomenon of T-wave alternans (TWA) (i.e., a beat-to-beat alternation in the morphology and amplitude of the ST- segment or T-wave). This statement focuses on its physiological basis and measurement technologies and its clinical utility in stratifying risk for life-threatening ventricular arrhythmias. Signal processing techniques including the frequency-domain Spectral Method and the time-domain Modified Moving Average method have demonstrated the utility of TWA in arrhythmia risk stratification in prospective studies in >12,000 patients. The majority of exercise-based studies using both methods have reported high relative risks for cardiovascular mortality and for sudden cardiac death in patients with preserved as well as depressed left ventricular ejection fraction. Studies with ambulatory electrocardiogram-based TWA analysis with Modified Moving Average method have yielded significant predictive capacity. However, negative studies with the Spectral Method have also appeared, including 2 interventional studies in patients with implantable defibrillators. Meta-analyses have been performed to gain insights into this issue. Frontiers of TWA research include use in arrhythmia risk stratification of individuals with preserved ejection fraction, improvements in predictivity with quantitative analysis, and utility in guiding medical as well as device-based therapy. Overall, although TWA appears to be a useful marker of risk for arrhythmic and cardiovascular death, there is as yet no definitive evidence that it can guide therapy.

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Section: Clinical Utilitymentioning

confidence: 99%

Microvolt T-Wave Alternans

Verrier

Klingenheben

Malík

et al. 2011

Journal of the American College of Cardiology

Self Cite

377

141

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“…A recent theory, which has been put forward, is that napping has benefits in therapeutic healing and medical treatments, such as bringing down stress and blood pressure (Koroboki et al 2012), and stimulating significant positive recovery in cardiovascular diseases (Naska et al 2007;Zaregarizi et al 2007;Brindle and Conklin 2012). Nap could function in managing sleep deprivation and arrhythmia (abnormal heartbeat) due to interfered circadian cycle (Verrier and Josephson 2009). The midday nap could function in recovering negative physical and psychological symptoms due to interfered night sleep (Bonnefond et al 2001;Macchi et al 2002) or narcolepsy (Takahashi 2003).…”

Section: Neuroscience Perspective Of Midday Nappingmentioning

confidence: 99%

The Concept of Qailulah (Midday Napping) from Neuroscientific and Islamic Perspectives

et al. 2015

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Napping/siesta during the day is a phenomenon, which is widely practised in the world. However, the timing, frequency, and duration may vary. The basis of napping is also diverse, but it is mainly done for improvement in alertness and general well-being. Neuroscience reveals that midday napping improves memory, enhances alertness, boosts wakefulness and performance, and recovers certain qualities of lost night sleep. Interestingly, Islam, the religion of the Muslims, advocates midday napping primarily because it was a practice preferred by Prophet Muhammad (pbuh). The objectives of this review were to investigate and compare identical key points on focused topic from both neuroscientific and Islamic perspectives and make recommendations for future researches.

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“…It is considered to represent a form of atrial fibrillation particularly affecting males aged 40 to 50 years. The arrhythmic episodes manifest themselves most often during the night, when parasympathetic predominance occurs [73] preceded by bradycardia, is not triggered by stress and lasts from minutes to hours [74,75]. It has been reported that vagally mediated atrial fibrillation is present in normal, pathologically unchanged heart, whereas patients with structural heart diseases more often have sympathetically induced atrial fibrillation [73,76].…”

Section: Role Of G Protein Related Kinases In Neurally Mediated Syncomentioning

confidence: 99%

“…The arrhythmic episodes manifest themselves most often during the night, when parasympathetic predominance occurs [73] preceded by bradycardia, is not triggered by stress and lasts from minutes to hours [74,75]. It has been reported that vagally mediated atrial fibrillation is present in normal, pathologically unchanged heart, whereas patients with structural heart diseases more often have sympathetically induced atrial fibrillation [73,76]. Pathogenesis of vagally induced atrial fibrillation is probably through downregulation of the inward potassium current [72] but the role of GRK in the proposed molecular mechanism is still not defined.…”

Section: Role Of G Protein Related Kinases In Neurally Mediated Syncomentioning

confidence: 99%

State of the art paper The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology

Bojić¹,

Sudar-Milovanović²,

Mikhailidis³

et al. 2012

aoms

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A b s t r a c tIn coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of β-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of postischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of β-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for scientific research.K Ke ey y w wo or rd ds s: : autonomic, sympathetic, vagal, molecular signaling pathway. Neurocardiovascular pathophysiology: sympathetic versus vagally mediated disordersNeural control of the cardiovascular (CV) system is an integral part of CV physiology and consequently a part of CV pathological mechanisms. Two fundamental parts of the autonomic nervous system -the sympathetic and parasympathetic (vagal) components -play a role in the development and initiation of the pathological process. The classification of neurocardiological disorders by Goldstein [1] is as follows: 1) Sympathetic disorders -diseases in which activation of the catecholamine system worsens an independent pathological state (coronary artery disease, arrhythmias as long QT syndrome, sudden death, heart failure (HF)) as well as diseases in which abnormal catecholaminergic function is etiologic (sympathetic neurocirculatory failure, hypertension, cardiac necrosis and cardiomyopathy), and 2) Vagally mediated disorders -both neurally mediated syncope (vasovagal syncope, carotid sinus hypersensitivity) and vagally mediated atrial fibrillation. Neural regulation of the CV system can be studied by using different techniques [2][3][4][5][6][7][8]. G protein related kinases (GRKs) exist in 7 isoforms -GRK 1-7. They are serine-threonine protein kinases that are C Co or rr re es sp po on nd di in ng g a au ut th ho or r: :

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Impact of Sleep on Arrhythmogenesis

Cited by 70 publications

References 94 publications

Microvolt T-Wave Alternans

Microvolt T-Wave Alternans

The Concept of Qailulah (Midday Napping) from Neuroscientific and Islamic Perspectives

State of the art paper The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology

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