Impact of sleep disturbances in inflammatory bowel disease

Ranjbaran, Ziba; Keefer, Laurie; Farhadi, Ashkan; Stepanski, Edward J.; Sedghi, Shahriar; Keshavarzian, Ali

doi:10.1111/j.1440-1746.2006.04820.x

Cited by 205 publications

(189 citation statements)

References 28 publications

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“…Given that IBS can be developed or exacerbated by psychiatric stress and the significant associations between sleep disturbances and IBS, [35][36][37] we compared the factors of sleep and mood among the SCT types ( Table 2). Among variables of mood status, PWI-SF score and psychological distress were significantly higher in the SE type than in the TE and SY types, implying that SE individuals experience more psychological stress than do other constitutions.…”

Section: Sleep and Mood Status According To Sctmentioning

confidence: 99%

So-Eum Type as an Independent Risk Factor for Irritable Bowel Syndrome: A Population-Based Study in Korea

Lee

Yoon²,

Yi³

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objectives: It has been hypothesized that Sasang constitutional types (SCTs) have a specific hypoactive organ, which can account for vulnerability to related diseases or symptoms. This study examined the relationship between SCTs and irritable bowel syndrome (IBS). Design: Cross-sectional study in a population-based cohort study in Korea. Participants: 1362 individuals (705 men and 657 women) who participated in the Korean Genome and Epidemiology Study. Outcome measures: The participants were classified into SCTs by the integrated diagnostic model and asked about symptoms related to IBS using the Rome II criteria. Results: The prevalence of IBS differed significantly among the SCTs, with 33 (18.3%) of the So-eum (SE) type, 74 (9.9%) of the Tae-eum (TE) type, and 57 (13.2%) of the So-yang (SY) type having IBS. Even after adjustment for possible confounders, the SE type for both sexes continued to show 1.82-fold (95% confidence interval [CI], 1.05-3.16) excess odds of having IBS. Men with SE type had a 2.97 times (95% CI, 1.34-6.58) and a 2.50 times (95% CI, 1.15-5.47) significantly higher odds of having IBS than the TE and SY types, respectively. In analysis for the joint effect of SCT and psychological stress, the multivariate odds ratio of IBS was 3.21 (95% CI, 1.33-7.75) for the SE type and Psychological Well-Being Index-Short Form (PWI-SF) score ( < 27), and 5.83 (95% CI, 1.80-18.88) for the SE type and PWI-SF ( ‡ 27) compared with the TE type and PWI-SF score ( < 27). Conclusions: The SE type of SCT is an independent risk factor for IBS. The findings support the hypothesis that persons with SE type are vulnerable to gastrointestinal diseases.

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Section: Sleep and Mood Status According To Sctmentioning

confidence: 99%

So-Eum Type as an Independent Risk Factor for Irritable Bowel Syndrome: A Population-Based Study in Korea

Lee

Yoon²,

Yi³

et al. 2014

The Journal of Alternative and Complementary Medicine

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“…Increasingly, sleep is recognised for its role in immune homoeostasis, yet patients with CD frequently report unrefreshing and/or broken sleep that does not appear to be simply attributable to nocturnal symptoms. 2 Sleep dysfunction is reportedly common in patients with CD, 3,4 similar to other intestinal disorders such as irritable bowel syndrome (IBS), 5,6 though the pathogenesis remain unclear. 1,7 Furthermore, in inflammatory bowel disease (IBD), there appears to be a link with poor sleep quality and disease activity/relapse, 4,8 and poor sleep has been associated with severe fatigue and impaired QoL in several recent studies.…”

Section: Introductionmentioning

confidence: 99%

Sleep and physical activity measured by accelerometry in Crohn's disease

Langenberg

Papandony

Gibson

2015

Aliment Pharmacol Ther

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SummaryBackgroundSleep and physical activity are inherent to human living, yet appear affected by Crohn's disease (CD), resulting in fatigue and disability.AimTo objectively assess sleep quality and physical activity and their associations using accelerometers, comparing CD vs. matched healthy control (HC) subjects.MethodsExactly 49 CD and 30 HC subjects completed surveys encompassing self‐reported fatigue and sleep quality, pathology testing and wore an accelerometer for 7 days, measuring physical activity and sleep. In this cross‐sectional observational study, per‐group comparisons were performed and in CD, factors associated with reduced activity and/or sleep quality were assessed via multivariate analyses.ResultsRegarding physical activity, CD subjects overall performed less total accelerometer counts (median 1.3 × 106 vs. 2.0 × 106), were more sedentary (97.7% vs. 96.2%) and completed fewer bouts of moderate‐vigorous intensity exercise (1.0 vs. 5.0, each P < 0.01 (Mann–Whitney) than HC over 7 days. Factors associated with poor physical activity in CD included elevated serum CRP (OR = 22.6), lower vitamin D3 (OR = 13.1) and longer disease duration (OR = 1.2 per year, each P < 0.05). Regarding sleep, the CD group had similar total sleep time (median 458 vs. 447 min, P = 0.56), but more awakenings post‐sleep onset (22 vs. 11, P = 0.01). Factors associated with severe sleep dysfunction in CD included lower haemoglobin (OR = 6.7) concurrent anti‐TNF (OR = 6.5, each P < 0.05) and opioid therapy (OR = 6.6, P = 0.09).ConclusionUtilising objective measurement in a habitual context over 7 days, patients with Crohn's disease exhibited poorer sleep quality and less physical activity than well‐matched healthy controls.

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“…4 For YCMC, marijuana use carries risks for disease exacerbation from poor diet associated with heavy use, 11,12 airway inflammation, 13 and treatment/medication nonadherence from being impaired or sleep deprived. 7,[14][15][16][17] Emerging evidence suggests antiinflammatory effects from cannabinoids, the active ingredients in marijuana 18,19 ; however, no studies have established their therapeutic value for youth, and the American Academy of Pediatrics opposes all use of marijuana for children and adolescents, including for "medical use." 20 Despite the potential for alcohol and marijuana use to negatively affect health and treatment outcomes of YCMC, there are substantial gaps in knowledge about the prevalence and patterning of these behaviors among this group, and associations with knowledge and outcomes such as treatment adherence.…”

Section: What This Study Addsmentioning

confidence: 99%

Alcohol and Marijuana Use and Treatment Nonadherence Among Medically Vulnerable Youth

et al. 2015

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BACKGROUND AND OBJECTIVE: Adolescents face peak risks for onset and intensification of alcohol and marijuana use. However, we know little about these behaviors and their associations with knowledge or treatment adherence among chronically ill youth, a medically vulnerable group.METHODS: Cross-sectional assessment of consented youth ages 9 to 18 years receiving care for asthma/cystic fibrosis, type 1 diabetes, arthritis, or inflammatory bowel disease (IBD) by using a self-administered online tool. Prevalence and correlates of risk behaviors and associations with knowledge and treatment adherence were estimated using descriptive statistics and logistic regression, controlling for demographics, mental health, and the multiclinic sampling frame.RESULTS: Of 403 consented youth (75.8% response), 51.6% were girls, 75.1% were white, and average age was 15.6 years. Of high school youth, 36.5% and 12.7% reported past-year alcohol use and binge drinking, respectively; 20% reported past-year marijuana use. Among high school youth, 53.1% and 37.2% answered correctly that alcohol can interfere with their medications and laboratory tests; youth answering incorrectly were 8.53 and 4.46 times more likely to drink and binge drink, respectively (P values , .001). Thirty-two percent and 8.3% of high school youth reported regularly forgetting or skipping their medications in the past 30 days; compared with past-year nondrinking youth, drinkers were 1.79 and 1.61 times as likely to report regularly missing or skipping medications (P values , .05).CONCLUSIONS: Alcohol and marijuana use are common among youth with chronic medical conditions. Alcohol use is associated with treatment nonadherence. Education and preventive interventions are warranted to ameliorate risk. WHAT'S KNOWN ON THIS SUBJECT:Increasing percentages of youth are living with chronic medical conditions. Although adolescents face peak risks for onset and intensification of alcohol and marijuana use, we know little about these behaviors and their associations with treatment adherence among chronically ill youth. WHAT THIS STUDY ADDS:This study quantifies alcohol and marijuana use behaviors among a heterogeneous sample of chronically ill youth in aggregate and by condition, and measures associations between alcohol use/binge drinking and knowledge about alcohol interactions with medications/laboratory tests and also treatment nonadherence.

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Impact of sleep disturbances in inflammatory bowel disease

Cited by 205 publications

References 28 publications

So-Eum Type as an Independent Risk Factor for Irritable Bowel Syndrome: A Population-Based Study in Korea

So-Eum Type as an Independent Risk Factor for Irritable Bowel Syndrome: A Population-Based Study in Korea

Sleep and physical activity measured by accelerometry in Crohn's disease

Alcohol and Marijuana Use and Treatment Nonadherence Among Medically Vulnerable Youth

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