Impact of single neonatal serotonin treatment (hormonal imprinting) on the brain serotonin content and sexual behavior of adult rats

Csaba, G.; Knippel, Barbara; Karabélyos, Cs; Inczefi-Gonda, Ágnes; Hantos, Mónika; Tekes, Kornélia

doi:10.1016/s0024-3205(03)00666-0

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…Our data revealed that disruption of the 5HT system during early life lead to a sex-specific and long-lasting change in the morphology and density of the SERT-ir fibers within the OB of adult male rats. This suggests a sexually dimorphic response to altered levels of neonatal 5HT, which is consistent with previous rodent studies (Csaba et al, 2003; Hohmann et al, 2007; Uçeyler et al, 2010), and further supports this model in the etiology of neurodevelopmental disorders (Rodriguez-Porcel et al, 2011; Simpson et al, 2011). …”

Section: Discussionsupporting

confidence: 89%

“…Similarly, physical activity was reduced in adult male SERT knock-out mice compared to females (Uçeyler et al, 2010). Furthermore, after a single injection of 5HT into newborn rats, 5HT levels were reduced in the striatum of adult male rats and displayed increased sexual activity, while no obvious differences were detected in adult female rats (Csaba et al, 2003). Interestingly, perinatal exposure to CTM affected male locus coeruleus circuit function but was not seen in females (Darling et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…5HT neurons in the dorsal raphe nucleus midline group and median raphe nucleus have axons distributed throughout the brain including the cortex (Waterhouse et al, 1986) and the olfactory bulb (OB) (McLean and Shipley, 1987). Manipulation of this system during early stages of neurodevelopment has been shown to produce sex-specific neurobehavioral modifications that persist well into adulthood (Csaba et al, 2003; Hohmann et al, 2007; Uçeyler et al, 2010). For example, serotonergic neurotoxin injections with 5,7-dihydroxytrypatmine into the bilateral medial forebrain bundles of neonatal mice induced long-term changes in social and sensory behaviors, as well as a depletion of the 5HT-immunoreactive (5HT-ir) fibers in the cerebral cortex (Boylan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats

Zhang¹,

Dennis²,

Darling³

et al. 2013

Front. Cell. Neurosci.

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Manipulation of serotonin (5HT) during early development has been shown to induce long-lasting morphological changes within the raphe nuclear complex and serotonergic circuitry throughout the brain. Recent studies have demonstrated altered raphe-derived 5HT transporter (SERT) immunoreactive axonal expression in several cortical target sites after brief perinatal exposure to selective 5HT reuptake inhibitors such as citalopram (CTM). Since the serotonergic raphe nuclear complex projects to the olfactory bulb (OB) and perinatal 5HT disruption has been shown to disrupt olfactory behaviors, the goal of this study was to further investigate such developmental effects in the OB of CTM exposed animals. Male and female rat pups were exposed to CTM from postnatal day 8–21. After animals reach adulthood (>90 days), OB tissue sections were processed immunohistochemically for SERT antiserum. Our data revealed that the density of the SERT immunoreactive fibers decreased ~40% in the OB of CTM exposed male rats, but not female rats. Our findings support a broad and long-lasting change throughout most of the 5HT system, including the OB, after early manipulation of 5HT. Because dysfunction of the early 5HT system has been implicated in the etiology of neurodevelopmental disorders such as autism spectrum disorders (ASDs), these new findings may offer insight into the abnormal olfactory perception often noted in patients with ASD.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats

Zhang¹,

Dennis²,

Darling³

et al. 2013

Front. Cell. Neurosci.

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“…85 Imprinting with serotonin or endorphin influences the serotonin content of certain areas of the adult brain; 86,87 and there is also cross-imprinting. As serotonin levels of the brain are interrelated with aggression, 88,89 it can be surmised that the different neonatal endorphin levels evoked by pain during delivery can set up later aggressivity of the individual.…”

mentioning

confidence: 99%

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

Csaba

2007

Cell Biochemistry & Function

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Hormonal (chemical) imprinting which was first observed (and named) by us in the seventies of the last century, is a general biological phenomenon which takes place when the developing receptor meets its target hormone for the first time. Under the effect of imprinting, receptors mature and reach their maximal binding capacity. It also influences the cells' hormone production and different functions depending on receptors and hormones. Hormonal imprinting is present already at the unicellular level causing the development of specific receptors and helping the easier recognition of useful or harmful surrounding molecules. The phenomenon is an important factor in the survival of the species, as the effect of imprinting is transmitted to the progeny cell generations. At the same time it possibly helps the selection of molecules which are suitable for acting as hormones in higher ranked animals. In mammals, hormonal imprinting takes place perinatally and determines the function of receptor-signal-transduction systems as well as hormone production for life. However, there are other critical imprinting periods for continuously developing cells. Excess of the target hormones or presence of foreign molecules which are able to bind to the receptors, provoke faulty imprinting in the critical periods with life-long morphological, biochemical, functional or behavioural consequences. As many receptor-bound foreign molecules are used as medical treatments and many such molecules are present around us and inside us as environmental pollutants, they--causing faulty imprinting--are able to predispose the (human) organism to cardiovascular, endocrine, metabolic and cancerous diseases. It seems likely that this effect is connected with disturbance of DNA methylation process in the critical periods of life. There are some signs of the transgenerational effect of faulty imprinting and this could be manifested in the evolution of humans by an epigenetic route.

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“…The experiments demonstrate that a treatment with a receptor blocker molecule at weaning provokes broad spectrum imprinting as well as the agonist itself (administered neonatally; Csaba et al, 2003c). However, there are differences in the cells or organs of the effects.…”

Section: Resultsmentioning

confidence: 95%

Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

et al. 2004

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Impact of single neonatal serotonin treatment (hormonal imprinting) on the brain serotonin content and sexual behavior of adult rats

Cited by 12 publications

References 26 publications

Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats

Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats

Hormonal imprinting: phylogeny, ontogeny, diseases and possible role in present‐day human evolution

Effect of treatment at weaning with the serotonin antagonist mianserin on the brain serotonin and cerebrospinal fluid nocistatin level of adult female rats: a case of late imprinting

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