Impact of Simvastatin Therapy after Heart Transplantation

Wenke, K; Meiser, Bruno; Thiery, Joachim; Reichart, Bruno

doi:10.1007/s00059-005-2685-6

Cited by 33 publications

(20 citation statements)

References 4 publications

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“…These effects have been attributed to disruption of small GTP-binding proteins in the Ras superfamily, which derive their important post-translational isoprenoid modifications from the cholesterol biosynthesis pathway. [6][7][8][9] Therapeutic statin-mediated immunomodulatory activity has been demonstrated in animal models of asthma and sepsis. [10][11][12][13][14][15][16][17] Specifically, statins have been reported to improve survival in the cecal-ligation and puncture (CLP) and lipopolysaccharide (LPS)-injection models of sepsis.…”

Section: Introductonmentioning

confidence: 99%

Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages

Helmers

Gowda²,

Kain

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Cerebral malaria is responsible for a large proportion of the estimated one million deaths caused by Plasmodium falciparum malaria annually. This disease is associated with excessive pro-inflammatory cytokine production resulting from dysregulated host responses to infection. On the basis of reports indicating potent activity against host-mediated inflammatory disorders such as sepsis, we examined the activity of statins (3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors) on malaria-associated inflammation in vivo and in vitro . Simvastatin failed to improve survival or alter parasitemia in C57BL/6 mice infected with Plasmodium berghei ANKA, an experimental model of cerebral malaria. In vitro statin treatment potentiated production of tumor necrosis factor and interleukin-6 by murine peritoneal macrophages in response to P. falciparum glycosylphosphatidyl inositol, a Toll-like receptor 2 (TLR2) ligand. Statin treatment also potentiated pro-inflammatory cytokine production stimulated by a panel of TLR2 and TLR4 ligands. Our results indicate that statins fail to confer protection in experimental cerebral malaria and potentiate TLR-mediated proinflammatory cytokine production by primary murine macrophages.

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Section: Introductonmentioning

confidence: 99%

Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages

Helmers

Gowda²,

Kain

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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“…Additionally, statin use in heart transplant patients is associated with improved cardiac allograft vasculopathy in both adults [146] and children [147]. These results were also verified in a long-term (11 years) evaluation study of heart transplant patients [148]. The incidence of graft coronary vasculopathy confirmed by angiography was 34.6% vs. 73.9%, in the simvastatin and placebo groups, respectively (P < 0.01).…”

Section: C) Statins and Transplantationmentioning

confidence: 53%

Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications

Paraskevas¹,

Tzovaras²,

Briana³

et al. 2007

CPD

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Statins are pluripotent agents exhibiting multiple non-lipid-lowering actions. Besides their established role in the management of hypercholesterolemia, statins may also have beneficial actions in other pathological conditions, namely: a) osteoporosis and osteoporosis-related bone fractures, b) cancer, c) solid organ transplantation, d) cerebrovascular events (transient ischemic attack and stroke episodes), e) various neurological disorders, such as Alzheimer's disease, Parkinson's disease and multiple sclerosis, f) cardiac arrhythmias and heart failure, g) renal diseases, h) rheumatoid arthritis, i) autoimmune diseases, j) sepsis, and k) allergic asthma. We reviewed the literature searching for studies that support or oppose the use of statins in each proposed indication. In some of these emerging indications, a role for statin treatment is more firmly set; for others, current evidence is more controversial. Future trials may reveal more convincing evidence that will make statin use necessary in the therapeutic management of several diseases.

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“…The results of 4-, 8-, and 11-year follow-up studies of heart transplant patients by Wenke et al [85][86][87] are also interesting. The authors found, after an 11-year of follow-up, a 77% survival rate in the simvastatin group, as compared to 56.8% (p<0.05) in the control cohort.…”

Section: Use Of Statins In Transplantation Medicinementioning

confidence: 91%

Cytoprotective and Antiproliferative Effects of HMG-CoA Reductase Inhibitors

Lenicek¹

2006

CEI

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Inhibitors of HMG-CoA reductase (statins) are widely used for the treatment of hypercholesterolemia. Besides this very important action, several other effects of statins, contributing to the general benefit of patients with coronary heart disease, have recently been demonstrated. These include: stabilization of atheroma plaques; inhibition of platelet aggregation; anti-inflammatory effects; improvement of vasomotor and endothelial function; antiproliferative effects on vascular smooth muscle cells; and effects on fibrinolytic activity, resulting in a decreased mortality from coronary heart disease, regardless of the influence on the serum cholesterol levels. Other effects of statins involve antioxidative, immunomodulatory and potential anti-tumor activities, as has been suggested by a number of studies either demonstrating the beneficiary activities of statins on the rejection of transplanted organs, or the low prevalence of cancer in patients having received statin medication. The aim of the present survey is to summarize current knowledge in this biomedical field and to demonstrate the enormous curative potential of this group of drugs.

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Impact of Simvastatin Therapy after Heart Transplantation

Cited by 33 publications

References 4 publications

Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages

Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages

Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications

Cytoprotective and Antiproliferative Effects of HMG-CoA Reductase Inhibitors

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