Impact of short-term exposure to fine particulate matter air pollution on urinary metabolome: A randomized, double-blind, crossover trial

Chen, Chen; Li, Huichu; Niu, Yue; Liu, Cong; Lin, Zhijing; Cai, Jing; Li, Weihua; Ge, Wenzhen; Chen, Renjie; Kan, Haidong

doi:10.1016/j.envint.2019.05.072

Cited by 59 publications

(41 citation statements)

References 35 publications

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“…Sphingolipid is also implicated in membrane biology [49] and has been linked to diabetes, hepatocellular carcinoma, and Alzheimer's disease [50,51], heart failure [52], and cancer [47]. We observed perturbations in glutathione metabolism, involved in xenobiotic-mediated oxidative stress [53,54], which has been reported to be associated with traffic-related air pollution [55]. We observed perturbations in the metabolism of sulfurcontaining amino acids, taurine and hypotaurine, which are readily oxidized [56].…”

Section: Discussionmentioning

confidence: 90%

Metabolomic signatures of the long-term exposure to air pollution and temperature

et al. 2021

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Background Long-term exposures to air pollution has been reported to be associated with inflammation and oxidative stress. However, the underlying metabolic mechanisms remain poorly understood. Objectives We aimed to determine the changes in the blood metabolome and thus the metabolic pathways associated with long-term exposure to outdoor air pollution and ambient temperature. Methods We quantified metabolites using mass-spectrometry based global untargeted metabolomic profiling of plasma samples among men from the Normative Aging Study (NAS). We estimated the association between long-term exposure to PM2.5, NO2, O3, and temperature (annual average of central site monitors) with metabolites and their associated metabolic pathways. We used multivariable linear mixed-effect regression models (LMEM) while simultaneously adjusting for the four exposures and potential confounding and correcting for multiple testing. As a reduction method for the intercorrelated metabolites (outcome), we further used an independent component analysis (ICA) and conducted LMEM with the same exposures. Results Men (N = 456) provided 648 blood samples between 2000 and 2016 in which 1158 metabolites were quantified. On average, men were 75.0 years and had an average body mass index of 27.7 kg/m2. Almost all men (97%) were not current smokers. The adjusted analysis showed statistically significant associations with several metabolites (58 metabolites with PM2.5, 15 metabolites with NO2, and 6 metabolites with temperature) while no metabolites were associated with O3. One out of five ICA factors (factor 2) was significantly associated with PM2.5. We identified eight perturbed metabolic pathways with long-term exposure to PM2.5 and temperature: glycerophospholipid, sphingolipid, glutathione, beta-alanine, propanoate, and purine metabolism, biosynthesis of unsaturated fatty acids, and taurine and hypotaurine metabolism. These pathways are related to inflammation, oxidative stress, immunity, and nucleic acid damage and repair. Conclusions Using a global untargeted metabolomic approach, we identified several significant metabolites and metabolic pathways associated with long-term exposure to PM2.5, NO2 and temperature. This study is the largest metabolomics study of long-term air pollution, to date, the first study to report a metabolomic signature of long-term temperature exposure, and the first to use ICA in the analysis of both.

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Section: Discussionmentioning

confidence: 90%

Metabolomic signatures of the long-term exposure to air pollution and temperature

et al. 2021

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“…In our study, we found that both Krebs cycle-related metabolites (succinic acid, pyruvic acid, and aconitic acid) produced by mitochondria and acylcarnitines (acetylcarnitine and butyrylcarnitine) involved in fatty acid oxidation in mitochondria were positively associated with PFASs exposure. Similarly, the urinary levels of these intermediate metabolites in mitochondrial metabolism were also found to be associated with other environmental stressors, including fine particulate matter air pollution (PM 2.5 ) ( Chen et al, 2019 ), heavy metals ( Al-Madani et al, 2010 ), and respiratory syncytial virus infection ( Turi et al, 2018 ). The accumulation of succinic acid and acylcarnitines may induce mitochondrial reactive oxygen species (ROS) generation and cause tissue injury ( Muoio and Neufer, 2012 , Zhang et al, 2020b ).…”

Section: Discussionmentioning

confidence: 99%

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Song

Wang

et al. 2021

Environment International

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“… 36 , 37 One small randomized control trial in China looked at changes in the urinary metabolome associated with reducing PM 2.5 using air filters, and found that in the experimental condition with higher particulate matter, subjects had biomarkers that suggested higher inflammation. 9 Toxicological evidence in mice also suggests that an increase in PM 2.5 exposure may be associated with signs of fibrosis in kidney tissues (a response to chronic inflammation), as well as capillary congestion and a reduction in glomerular urinary space. 10 Other common arguments suggest that air pollutants may increase the occurrence of bacteria, viruses, or other pathogens in ambient air, 38 and that ambient air pollution may act as an immunosuppressive factor that can undermine the normal human body defenses.…”

Section: Discussionmentioning

confidence: 99%

“…8 At least 1 doubleblind epidemiological study also supports the idea that air pollution levels influence changes in systemic metabolism. 9 There has also been evidence in toxicological studies that ambient air pollution, especially fine particulate matter (PM 2.5 ) is associated with several different markers of kidney function, including estimated glomerular filtration rate (eGFR). 10 In this study, we took a wide scope approach to investigate the potential relationship between air pollution and ED visits for genitourinary problems.…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Emergency Department Visits for Disease of the Genitourinary System

Szyszkowicz

Schoen

Angelis

2021

Environ�Health�Insights

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The aim of this study is to determine associations between ambient air pollution and the number of emergency department (ED) visits for diseases of the genitourinary tract in Toronto, Canada. We used the National Ambulatory Care Reporting System (NACRS) database to obtain the related ED visits and developed statistical models using daily data on ED visits, temperature, relative humidity, and outdoor air pollution concentration levels. The NACRS database contains data on hospital-based and community-based ambulatory care. The environmental data were retrieved from the National Air Pollution Surveillance (NAPS) program. The NAPS is the main source of ambient air quality data in Canada. We considered 2 air quality health indexes and 6 air pollutants: daily means of fine particulate matter PM2.5, O3, CO, NO2, SO2, and also maximum 8-hour average ozone. For every air pollutant, we fit 270 models (15 lags × 18 strata). We found that same-day air pollution concentrations have the highest number of statistically significantly positive associations with ED visits for genitourinary health outcomes. A total of 133 positive associations were identified over the 14 days lag. In subgroup (strata) analysis, females older than 60 years of age were found to have the most positive associations. In particular, nitrogen dioxide was found to be highly associated with ED visits for females over 60; an increase in NO2 was associated with an increased relative risk (RR) of ED visits when lagged over 0, 1, and 2 days (RR = 1.040 [95% confidence interval: 1.028, 1.052], 1.020 [1.009, 1.032], and 1.025 [1.013, 1.036], respectively). The values of risks are reported for a 1 interquartile range increase in concentration (8.8 ppb). Our results suggest that urban ambient air pollution affect the number of ED visits due to genitourinary system conditions.

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Impact of short-term exposure to fine particulate matter air pollution on urinary metabolome: A randomized, double-blind, crossover trial

Cited by 59 publications

References 35 publications

Metabolomic signatures of the long-term exposure to air pollution and temperature

Metabolomic signatures of the long-term exposure to air pollution and temperature

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Air Pollution and Emergency Department Visits for Disease of the Genitourinary System

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