Impact of Short-Term Administration of High-Density Lipoproteins and Atorvastatin on Atherosclerosis in Rabbits

Nicholls, Stephen J.; Cutri, Belinda; Worthley, Stephen G.; Kee, Patrick; Rye, Kerry Anne; Bao, Shisan; Barter, Philip J.

doi:10.1161/01.atv.0000184760.95957.d6

Cited by 145 publications

(93 citation statements)

References 45 publications

(30 reference statements)

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“…Elevation of HDL-C, via infusion of HDL [12] or transgenic expression of apoA-I [18], results in a reduction of macrophages and chemokines within established atherosclerotic lesions. This was further supported by the recent report that infusion of small amounts of reconstituted or native HDL, without an increase in systemic HDL-C levels, rapidly reduces lesion size ( Figure 4) and increases the ratio of smooth muscle cells to macrophages ( Figure 5) in a model of established atherosclerotic plaque, induced by aortic balloon denudation in the cholesterol-fed rabbit [38]. This suggests that the quality of HDL that is administered, rather than the systemic level of HDL-C achieved, is of particular importance in potential remodelling of established atherosclerotic plaque and its proclivity to result in clinical ischaemia.…”

Section: Anti-inflammatory Propertiessupporting

confidence: 68%

High-density lipoproteins: an emerging target in the prevention of cardiovascular disease

2006

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High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall. A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against the development of atherosclerotic plaque. This paper will review how the promotion of the functional properties of HDL inhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.

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Section: Anti-inflammatory Propertiessupporting

confidence: 68%

High-density lipoproteins: an emerging target in the prevention of cardiovascular disease

2006

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“…The antioxidative function of apoA-I was corroborated by the finding that recombinant HDL containing only apoA-I and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) was as effective as native HDL in preventing LDL oxidation. In addition, in vivo studies have demonstrated that apoA-I can act as an antioxidative, anti-inflammatory, and anti-atherosclerotic agent (Nicholls et al 2005a, b;Paszty et al 1994). This further underlines a key antioxidant role for the HDL major protein apoA-I (Zerrad-Saadi et al 2009).…”

Section: Mechanisms Under Physiological Conditionsmentioning

confidence: 95%

Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers

Riwanto

Rohrer

Eckardstein

et al. 2014

High Density Lipoproteins

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Reduced plasma levels of HDL-C are associated with an increased risk of CAD and myocardial infarction, as shown in various prospective population studies. However, recent clinical trials on lipidmodifying drugs that increase plasma levels of HDL-C have not shown significant clinical benefit. Notably, in some recent clinical studies, there is no clear association of higher HDL-C levels with a reduced risk of cardiovascular events observed in patients with existing CAD. These observations have prompted researchers to shift from a cholesterol-centric view of HDL towards assessing the function and composition of HDL particles. Of importance, experimental and translational studies have further demonstrated various potential antiatherogenic effects of HDL. HDL has been proposed to promote macrophage reverse cholesterol transport and to protect endothelial cell functions by prevention of oxidation of LDL and its adverse endothelial effects. Furthermore, HDL from healthy subjects can directly stimulate endothelial cell production of nitric oxide and exert anti-inflammatory and antiapoptotic effects. Of note, increasing evidence suggests that the vascular effects of HDL can be highly heterogeneous and HDL may lose important anti-atherosclerotic properties and turn dysfunctional in patients with chronic inflammatory disorders. A greater understanding of mechanisms of action of HDL and its altered vascular effects is therefore critical within the context of HDL-targeted therapies.

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“…Studies of HDL infusions into cholesterol-fed rabbits indicate that HDL upregulates endothelial cell thrombomodulin, which is an additional anticoagulant factor. 22 Therefore the reduction of HDL maybe one of the initiating factors for pulmonary arterial trunk embolism. As reported by Yang et al, 23 the level of HDL became elevated in VTE patients after heparin therapy.…”

Section: Discussionmentioning

confidence: 99%

Correlation Study of Pulmonary Embolism and High‐density Lipoprotein Cholesterol

Wang

2010

Clinical Cardiology

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Background: It is currently thought that pulmonary embolism and deep vein thrombosis are different manifestations of the same pathological process of venous thromboembolism. Venous thromboembolism has a negative correlation with high-density lipoprotein cholesterol. Hypothesis: Pulmonary embolism has a negative correlation with the level of high-density lipoprotein cholesterol. Methods: A total of 90 patients with pulmonary embolism, diagnosed and treated at a single center, were retrospectively analyzed for the present study. Among them were 57 cases of pulmonary arterial trunk embolism in group A and 33 cases of pulmonary arterial non-trunk embolism in group B.Results: The results showed that the level of high-density lipoprotein cholesterol decreased markedly in patients with pulmonary arterial trunk embolism as compared to those with pulmonary arterial non-trunk embolism. A stepwise logistic regression analysis was performed upon the relationship between pulmonary arterial trunk embolism and multiple factors. The results showed that a pulmonary arterial trunk embolism had a negative correlation with the level of high-density lipoprotein cholesterol and a positive correlation with triglyceride and high sensitivity C-reactive protein.Conclusions: Pulmonary arterial trunk embolism is negatively correlated with the level of high-density lipoprotein cholesterol.

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Impact of Short-Term Administration of High-Density Lipoproteins and Atorvastatin on Atherosclerosis in Rabbits

Cited by 145 publications

References 45 publications

High-density lipoproteins: an emerging target in the prevention of cardiovascular disease

High-density lipoproteins: an emerging target in the prevention of cardiovascular disease

Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers

Correlation Study of Pulmonary Embolism and High‐density Lipoprotein Cholesterol

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