Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke

Tomita, Hirofumi; Hagii, Joji; Metoki, Norifumi; Saito, Shin; Shiroto, Hiroshi; Hitomi, Hiroyasu; Kamada, Takenobu; Seino, Satoshi; Takahashi, Kei; Baba, Yoshiko; Sasaki, Satoshi; Uchizawa, Takamitsu; Iwata, Manabu; Matsumoto, Shigeo; Yamanaka, Shōji; Tanno, Tomohiro; Osanai, Tomohiro; Yasujima, Minoru; Okumura, Ken

doi:10.1016/j.jstrokecerebrovasdis.2015.07.016

Cited by 34 publications

(27 citation statements)

References 13 publications

(11 reference statements)

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“…Our findings of women in our cohort being less likely to be on anticoagulation and even then being less likely to be prescribed a DOAC have important clinical implications as they could be contributing to gender disparities in outcomes. Furthermore, women who are admitted with embolic stroke have more severe neurological deficits on admission and worse functional outcome at discharge [23], further emphasizing the importance of understanding gender disparities in AF management. It is of interest that the rates of anticoagulation were higher in men (79%) and women (73%) in the lowest CHADS 2 score risk category in our cohort compared to other reports [24].…”

Section: Discussionmentioning

confidence: 99%

Gender differences in management and clinical outcomes of atrial fibrillation patients

Kassim

Althouse

Qin

et al. 2017

Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Gender differences in management and clinical outcomes of atrial fibrillation patients

Kassim

Althouse

Qin

et al. 2017

Journal of Cardiology

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“…Stroke and systemic thromboembolism are the most clinically important complications observed in patients with atrial fibrillation (AF) [1]. Stroke caused by AF is defined as cardioembolic stroke, and once it occurs, it often results in death (up to 20%) or disability (approximately 60%) [2–4]. Therefore, appropriate thromboprophylaxis is mandatory.…”

Section: Epidemiology Of Atrial Fibrillation‐associated Stroke In Asiamentioning

confidence: 99%

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

Chiang

Okumura

Zhang

et al. 2017

Journal of Arrhythmia

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154

193

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Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2-fold increase in mortality and a 5-fold increase in stroke. The Asian population is rapidly aging, and in 2050, the estimated population with AF will reach 72 million, of whom 2.9 million may suffer from AF-associated stroke. Therefore, stroke prevention in AF is an urgent issue in Asia. Many innovative advances in the management of AF-associated stroke have emerged recently, including new scoring systems for predicting stroke and bleeding risks, the development of non-vitamin K antagonist oral anticoagulants (NOACs), knowledge of their special benefits in Asians, and new techniques. The Asia Pacific Heart Rhythm Society (APHRS) aimed to update the available information, and appointed the Practice Guideline sub-committee to write a consensus statement regarding stroke prevention in AF. The Practice Guidelines sub-committee members comprehensively reviewed updated information on stroke prevention in AF, emphasizing data on NOACs from the Asia Pacific region, and summarized them in this 2017 Consensus of the Asia Pacific Heart Rhythm Society on Stroke Prevention in AF. This consensus includes details of the updated recommendations, along with their background and rationale, focusing on data from the Asia Pacific region. We hope this consensus can be a practical tool for cardiologists, neurologists, geriatricians, and general practitioners in this region. We fully realize that there are gaps, unaddressed questions, and many areas of uncertainty and debate in the current knowledge of AF, and the physician׳s decision remains the most important factor in the management of AF.

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“…, Tomita et al . ). Women have a higher risk than men to develop one or a combination of the three major stroke‐related risk factors; hypertension, atrial fibrillation and possible diabetes that worsen stroke outcomes (Roquer et al .…”

Section: Discussionmentioning

confidence: 97%

“…For example, women are more likely to have more severe strokes and have greater long‐term post‐stroke disability relative to men (Tomita et al . ). Consequently, many women experience worse functional recovery than men and greater post‐stroke disability that translates into poorer quality of life (Gall et al .…”

Section: Introductionmentioning

confidence: 97%

Gender differences in aphasia outcomes: evidence from the AphasiaBank

Sharma

Briley

Wright

et al. 2019

Intl J Lang & Comm Disor

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Background: Stroke is one of the leading causes of death in the United States. Aphasia is a language impairment which results as a consequence of stroke. Gender differences are reported in underlying mechanisms of stroke, however, gender differences in aphasia type and severity remain unclear. Aims: To examine gender differences in aphasia impairment based on data from AphasiaBank, a research repository of data obtained from studies of aphasia. Methods & Procedures:The data were collected from AphasiaBank for 294 persons with aphasia (PWA) (172 men, 122 women). Baseline comparisons by gender groups were completed using independent samples t-tests and Pearson Chi square statistics. Univariate comparisons of the total Western Aphasia Battery-Revised (WAB-R) -AQ and -R subtests' scores were compared between the two groups using independent samples t-tests. Multivariate comparisons were completed by using multivariate analysis of variance (MANOVA). Outcomes & Results: Gender differences were observed in the severity of aphasia with men exhibiting more severe aphasia than women. Analyses of WAB-R indicated greater impairment among men based on AQ and greater impairment was observed in individual subtest performance. Men exhibited statistically significantly lower WAB-R AQs than women (67.4 versus 75.6). Lower WAB-R AQs were derived from lower scores among men on individual subtests; information content, fluency, repetition, sentence completion, responsive speech and tests of comprehension (yes/no, auditory word recognition and sequential commands). Conclusions & Implications:This study offers evidence of gender differences in aphasia severity, global communication impairment and lower scores on individual subtests used to derive the WAB-R AQ. The limitations of the study with suggestions for future directions are presented.

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Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke

Cited by 34 publications

References 13 publications

Gender differences in management and clinical outcomes of atrial fibrillation patients

Gender differences in management and clinical outcomes of atrial fibrillation patients

2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation

Gender differences in aphasia outcomes: evidence from the AphasiaBank

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