Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing

Heinzer, Raphaël; Martí-Soler, Helena; Marques‐Vidal, Pedro; Tobback, Nadia; Andries, Daniela; Waeber, Gérard; Preisig, Martin; Vollenweider, Péter; Haba‐Rubio, José

doi:10.1016/j.sleep.2018.04.016

Cited by 70 publications

(49 citation statements)

References 40 publications

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“…2). The distribution of comorbidities differed between men and women, with diabetes and ischemic heart disease being more prevalent in men with OSA, and hypertension and depression being more prevalent in women with OSA compared to non-OSA subjects [3, 7]. According to some studies, the comorbidity burden progressively increases with OSA severity [5, 6, 8, 9].…”

Section: Comorbidities In Osa: the Size Of The Problemmentioning

confidence: 99%

Obstructive sleep apnea and comorbidities: a dangerous liaison

Bonsignore

Baiamonte

Mazzuca

et al. 2019

Multidiscip Respir Med

178

116

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Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and cancer. Better phenotypic characterization of OSA patients, including comorbidities, will help to provide better individualized care. The unsatisfactory adherence to CPAP in patients without daytime sleepiness should prompt clinicians to examine the overall risk profile of each patient in order to identify subjects at high risk for worse prognosis and provide the optimal treatment not only for OSA, but also for comorbidities.

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Section: Comorbidities In Osa: the Size Of The Problemmentioning

confidence: 99%

Obstructive sleep apnea and comorbidities: a dangerous liaison

Bonsignore

Baiamonte

Mazzuca

et al. 2019

Multidiscip Respir Med

178

116

View full text Add to dashboard Cite

show abstract

“…Specifically, a few studies have demonstrated a stronger association between glycemic disturbances, including type 2 diabetes, and OSA with men compared to women. [28][29][30] However, the interaction between sex and OSA symptoms in modifying the association between OSA and health outcomes is not well established. There is limited but accumulating evidence that daytime sleepiness may be an important prognostic indicator of worse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes

Aurora

Punjabi

2019

Journal of Clinical Sleep Medicine

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Study Objectives: Self-reported sleepiness is common in patients with obstructive sleep apnea (OSA) and is being increasingly recognized as an effect modifier of the association between OSA and cardiovascular outcomes. However, data on whether sleepiness modifies the association between OSA and glycemic outcomes are lacking. The current study sought to characterize the association between glycemic control and sleepiness in people with OSA and type 2 diabetes. Methods: Adults with non-insulin requiring type 2 diabetes and undiagnosed moderate to severe OSA were recruited from the community. Demographic data, Epworth Sleepiness Scale (ESS), hemoglobin A1c (HbA1c), as well a type III home sleep test were obtained. The association between self-reported sleepiness and glycemic control was examined using quantile regression. Results: The study cohort included 311 participants with 56% of the sample being men. Stratified analyses by sex demonstrated that self-reported sleepiness was associated with a higher HbA1c level, but this association was present only in men with a body mass index (BMI) < 35 kg/m 2. Mean HbA1c levels were higher by 0.57% (95% confidence interval: 0.11, 1.02) in men with an ESS ≥ 11 compared to men with an ESS < 11. No such association was observed in men with a BMI ≥ 35 kg/m 2 or in women of any BMI category. Conclusions: The association between self-reported sleepiness and glycemic control in people with type 2 diabetes and moderate to severe OSA varies a function of BMI and sex. The noted differences in association should be considered when assessing possible treatment effects of therapy for OSA on metabolic outcomes.

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“…Women in the menopausal period equate their apnea index with that of men, and it is believed that estrogen and progesterone maintain adequate muscle tone in the premenopausal period. 16 , 17 …”

Section: Risk Factorsmentioning

confidence: 99%

Obstructive sleep apnea in adults

Faber

Faber³

2019

Dental Press J. Orthod.

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Introduction: Obstructive Sleep Apnea and Hypopnea Syndrome (OSAS) is a highly prevalent disease with serious consequences for the patients’ lives. The treatment of the condition is mandatory for the improvement of the quality of life, as well as the life expectancy of the affected individuals. The most frequent treatments provided by dentistry are mandibular advancement devices (MAD) and orthognathic surgery with maxillomandibular advancement (MMA). This is possibly the only treatment option which offers high probability of cure. Objective: The present article provides a narrative review of OSAS from the perspective of 25 years of OSAS treatment clinical experience. Conclusion: MADs are a solid treatment option for primary snoring and mild or moderate OSAS. Patients with severe apnea who are non-adherent to CPAP may also be treated with MADs. Maxillomandibular advancement surgery is a safe and very effective treatment option to OSAS.

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Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing

Cited by 70 publications

References 40 publications

Obstructive sleep apnea and comorbidities: a dangerous liaison

Obstructive sleep apnea and comorbidities: a dangerous liaison

Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes

Obstructive sleep apnea in adults

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