Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

Wang, Kai; Ju, Qing; Cao, Jiang; Tang, Wenze; Zhang, Jiän

doi:10.1097/md.0000000000007083

Cited by 67 publications

(53 citation statements)

References 55 publications

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“…There are various reported biomarkers of IPF 22 . Of these, serum levels of surfactant protein A (SP-A) and D (SP-D), which are synthesized and secreted by ATII, have been reported to predict mortality 23 , exacerbation 24 , or progression 25 of IPF. The increase of these ATII-associated proteins may reflect alveolar dysfunction induced by alveolar injury processes in IPF.…”

Section: Discussionmentioning

confidence: 99%

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Ota

Ng-Blichfeldt

Korfei

et al. 2018

Sci Rep

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Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (HOPX) contributes to the formation of distal lung during development. In adult lung, alveolar epithelial type (AT) I cells express HOPX and lineage-labeled Hopx+ cells give rise to both ATI and ATII cells after pneumonectomy. However, the cell function of HOPX-expressing cells in adult fibrotic lung diseases has not been investigated. In this study, we have established a flow cytometry-based method to evaluate HOPX-expressing cells in the lung. HOPX expression in cultured ATII cells increased over culture time, which was accompanied by a decrease of proSP-C, an ATII marker. Moreover, HOPX expression was increased in AECs from bleomycin-instilled mouse lungs in vivo. Small interfering RNA-based knockdown of Hopx resulted in suppressing ATII-ATI trans-differentiation and activating cellular proliferation in vitro. In IPF lungs, HOPX expression was decreased in whole lungs and significantly correlated to a decline in lung function and progression of IPF. In conclusion, HOPX is upregulated during early alveolar injury and repair process in the lung. Decreased HOPX expression might contribute to failed regenerative processes in end-stage IPF lungs.

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Section: Discussionmentioning

confidence: 99%

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Ota

Ng-Blichfeldt

Korfei

et al. 2018

Sci Rep

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“…[33][34][35] Surfactant protein A is also an important serum marker for ILD. 36,37 In patients with CTD-ILD, serum carcinoembryonic antigen and carbohydrate antigen 19-9 are elevated and can be indicators of disease severity. 38 Aside from immunosuppressive therapy, such as cyclophosphamide 2 and corticosteroids, 39 anti-fibrosis medicine, including pirfenidone and nintedanib, 40 is now applied to treat ILD.…”

Section: Systemic Lupus International Collaboratingmentioning

confidence: 99%

Association of Interstitial Lung Disease With Clinical Characteristics of Chinese Patients With Systemic Lupus Erythematosus

et al. 2020

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Objectives: This study aims to evaluate the frequency and clinical and laboratory features of interstitial lung disease (ILD) in Chinese patients with systemic lupus erythematosus (SLE) and to evaluate the association of ILD with the clinical features. Patients and methods: The study included 505 SLE patients (64 males, 441 females; mean age 35.3±15.3 years; range, 14 to 87 years) who were categorized into two groups as 449 patients without ILD and 56 patients with ILD based on evidence obtained from high-resolution computed tomography images. The demographic data, clinical and laboratory findings, SLE disease activity index score, and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index of all patients were also recorded and statistically analyzed. Results: The ILD frequency in patients with SLE was 11.1%. Compared to the group of SLE patients without ILD, the group of SLE patients with ILD possessed the following statistical differences: elderly age, longer illness duration, lower level of anti-double-stranded deoxyribonucleic acid, and higher level of serum complement 3, increased ratios of Raynaud's phenomenon, moist rales and tachypnea. Multivariate logistic regression results suggested that elderly age (≥60 years), long illness duration (1-10 years, ≥10 years), Raynaud's phenomenon, and tachypnea were statistically associated with the occurrence of ILD in SLE patients. Conclusion: Chinese SLE patients who possessed the factors that were statistically associated with ILD, namely, elderly age (≥60 years old), long illness duration (≥1 years), Raynaud's phenomenon, and tachypnea, were recommended to be monitored for the possibility of ILD.

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“…SP-D is a marker produced by type 2 alveolar epithelial cells, and elevates in such conditions as acute lung injuries, idiopathic pulmonary fibrosis, alveolar proteinosis, and pulmonary edema. [11][12][13][14] The patient's mild SP-D elevation suggests the presence of lung diseases involving type 2 epithelial cells. Elevated ANA suggests autoimmune or collagen vascular diseases.…”

Section: Clinical Discussionmentioning

confidence: 99%

A 47-Year-Old Woman With Pulmonary Nodules and Facial Hemispasms

Hirai

Oikawa

Tanino

et al. 2020

Chest

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A 47-year-old woman visited her primary physician for a health check, and some radiographic abnormalities were detected. She was referred to our division for further management. In recent years, she had become conscious of occasional facial hemispasms. She denied respiratory symptoms, smoking, alcohol consumption, and any particle inhalation. She had undergone oophorectomy and platinum-based chemotherapy because of ovarian cancer (serous cystadenocarcinoma stage Ia) at the age of 29 years, with no recurrence for 17 years. The patient was diagnosed with rheumatoid arthritis (RA) 5 years before being seen by us and had been treated with bucillamine. No signs of RA progression were evident, and the only used antirheumatic drug was bucillamine. The patient had no history of use of immune-modulating drugs or immunosuppressants. No previous chest radiographs or CT had been performed.

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Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis

Abstract: Supplemental Digital Content is available in the text

Cited by 67 publications

References 55 publications

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Association of Interstitial Lung Disease With Clinical Characteristics of Chinese Patients With Systemic Lupus Erythematosus

A 47-Year-Old Woman With Pulmonary Nodules and Facial Hemispasms

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