Impact of serum glycosylated <i>Wisteria floribunda</i> agglutinin positive Mac‐2 binding protein levels on liver functional reserves and mortality in patients with liver cirrhosis

Hanai, Taizo; Shiraki, Makoto; Ohnishi, Sachiyo; Miyazaki, Tsuneyuki; Ideta, Takayasu; Kochi, Takeshi; Imai, Kenji; Suetsugu, Atsushi; Koji, Takehiko; Shimizu, Masahito; Moriwaki, Hisataka

doi:10.1111/hepr.12473

Cited by 39 publications

(50 citation statements)

References 35 publications

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“…These results were consistent with the research by Hanai et al 42 reporting the relationship of WFA + -M2BP and liver reserve function as well as mortality in LC patients, and the study by Hasegawa et al 43 demonstrating that WFA + -M2BP <6.15 COI was a significant independent favorable predictor of survival in HCVrelated compensated LC. However, there were only six patients with HBV infection in the former study, 42 and the cohort of the latter study consisted of HCVrelated compensated LC, 43 while in China HBV infection is the most common etiology for LC. We have demonstrated the role of WFA + -M2BP for evaluating early-stage liver fibrosis in patients with HBV infection in a previous study.…”

Section: Discussionsupporting

confidence: 92%

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis

Wang

Zou

et al. 2018

J of Digest Diseases

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Section: Discussionsupporting

confidence: 92%

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis

Wang

Zou

et al. 2018

J of Digest Diseases

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“…A S MENTIONED EARLIER, WFA + -M2BP value has been shown to be a useful predictor for liver fibrosis in various etiologies of chronic liver diseases. [14][15][16][17][18]21,23 However, whether WFA + -M2BP value can be helpful for evaluating histological findings in NASH patients remains unclear, because there is only one existing report regarding the implication of WFA + -M2BP level on histological findings in NASH. Hence, we conducted the current analysis.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 The Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA + -M2BP) was recently established as a liver fibrosis glycobiomarker in patients with chronic hepatitis C (CHC) with a unique fibrosis-related glycoalteration and rapid bedside method, and it also has been shown as a predictive factor in patients with CHC-related HCC. [14][15][16][17][18] WFA + -M2BP has been demonstrated to have sialylated N-glycans and multibranching. 16,19,20 WFA + -M2BP is considered to recognize the clustered LacNAc (Gal-GlcNAc) structure or the GalNAc residue of N-glycans and O-glycans.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of serum Wisteria floribunda agglutinin positive Mac‐2‐binding protein level in non‐alcoholic steatohepatitis

Nishikawa

Enomoto

Iwata

et al. 2016

Hepatology Research

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Aim To examine the relationship between the Wisteria floribunda agglutinin positive Mac‐2‐binding protein (WFA+‐M2BP) level and histological findings for patients with non‐alcoholic steatohepatitis (NASH). Methods A total of 134 NASH patients (mean age, 51.7 years) were analyzed. We examined the effect of WFA+‐M2BP level on severity of liver fibrosis comparing with other laboratory markers, including aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, AST to platelet ratio index (APRI), FIB‐4 index, platelet count and hyaluronic acid as serum liver fibrosis markers. Receiver–operator curve (ROC) analysis was performed for calculating the area under the ROC (AUROC). Results The WFA+‐M2B P‐value ranged from 0.2 cut‐off index (COI) to 9.6 COI (median, 0.9). The median values in each fibrosis stage were: 0.7 COI in F1, 0.7 COI in F2, 1.2 COI in F3 and 2.4 COI in F4 (P < 0.001). For predicting liver cirrhosis (F4), WFA+‐M2BP level had the AUROC of 0.854 (sensitivity, 69.2%; specificity, 88.4%) and for predicting advanced liver fibrosis (≥F3), WFA+‐M2BP level yielded the second highest AUROC with a level of 0.842 (sensitivity, 73.7%; specificity, 80.2%) and for predicting significant liver fibrosis (≥F2), WFA+‐M2BP level yielded the highest AUROC with a level of 0.663 (sensitivity, 47.2%; specificity, 78.6%) among six liver fibrosis markers. The median values in patients with ballooning scores 1 (n = 58) and 2 (n = 76) were 0.6 and 1.1 COI, respectively (P < 0.001). Conclusion Serum WFA+‐M2BP level can be useful for assessing liver histological findings in patients with NASH.

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“…. M2BPGi is effective for the evaluation of fibrosis in patients infected with hepatitis B virus, but with a different cut-off value [58].…”

Section: Large-scale Validation Of M2bpgi In Clinical Studiesmentioning

confidence: 99%

Development of M2BPGi: a novel fibrosis serum glyco-biomarker for chronic hepatitis/cirrhosis diagnostics

Narimatsu

2015

Expert Review of Proteomics

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Many proteins in the living body are glycoproteins, which present glycans linked on their surface. Glycan structures reflect the degree of cell differentiation or canceration and are cell specific. These characteristics are advantageous in the development of various disease biomarkers. Glycoprotein-based biomarkers (glyco-biomarkers) are developed by utilizing the specific changes in the glycan structure on a glycoprotein secreted from the diseased cells of interest. Therefore, quantification of the altered glycan structures is the key to developing a new glyco-biomarker. Glycoscience is a relatively new area of molecular science, and recent advancement of glycotechnologies is remarkable. In the author's institute, new glycoscience technologies have been designed to be efficiently utilized for the development of new diagnostic agents. This paper introduces a strategy for glyco-biomarker development, which was successfully applied in the development of Wisteria floribunda agglutinin-positive Mac-2 binding protein M2BPGi, a liver fibrosis marker now commercially available for clinical use.

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Impact of serum glycosylated Wisteria floribunda agglutinin positive Mac‐2 binding protein levels on liver functional reserves and mortality in patients with liver cirrhosis

Abstract: Serum WFA(+) -M2BP levels were significantly correlated with both liver function reserves and liver fibrosis, and were independently associated with mortality in patients with LC.

Cited by 39 publications

References 35 publications

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis

Clinical significance of serum Wisteria floribunda agglutinin positive Mac‐2‐binding protein level in non‐alcoholic steatohepatitis

Development of M2BPGi: a novel fibrosis serum glyco-biomarker for chronic hepatitis/cirrhosis diagnostics

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