Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma

Imai, Kenji; Koji, Takehiko; Hanai, Taizo; Shiraki, Makoto; Suzuki, Yusuke; Hayashi, Hideki; Naiki, Taku; Nishigaki, Youichi; Tomita, Eiichi; Shimizu, Masahito; Moriwaki, Hisataka

doi:10.3390/ijms150711294

Cited by 28 publications

(41 citation statements)

References 39 publications

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“…In individuals with liver cirrhosis, the adipose tissue atrophies, which is likely to additionally reduce the production of chemerin. Imai et al have demonstrated that levels of chemerin in patients with liver cirrhosis complicated by HCC were inversely correlated with Child-Pugh scores [18]. Moreover, the results of the current study have shown that serum chemerin levels were significantly correlated with platelet counts.…”

Section: Discussionsupporting

confidence: 69%

Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis

Prystupa

Kiciński

Luchowska-Kocot

et al. 2019

Ann Agric Environ Med.

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Introduction. In Poland, an increasing number of patients are hospitalized due to liver diseases. One of the common liver diseases is cirrhosis, which can be caused by alcohol, viral hepatitis, autoimmune processes and metabolic diseases. Materials and method. The study included 99 patients with alcoholic cirrhosis from the Lublin region of Eastern Poland. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The concentrations of serum kallistatin and chemerin were determined using ELISA kits. Objective. The aim of the study is to evaluate serum levels of kallistatin and chemerin in patients with different stages of alcoholic liver cirrhosis. Results. The highest chemerin level was found in the control group-182.6±80.4 ng/ml. In other stages of liver cirrhosis, the following levels were observed: 175.7±62.7 ng/ml in Child-Pugh stage A (Ch-P A), 150.2±59.7 ng/ml in Ch-P B and 110.3±73.6 ng/ml in Ch-P C. Significant differences in chemerin levels between controls and Ch-P C patients (p=0.01), as well as between the Ch-P A patients and Ch-P C patients (p=0.02), were demonstrated. The highest kallistatin level was demonstrated in the control group-8.2±3.5 μg/ml. In other stages of liver cirrhosis, the following concentrations were found: 7.2±27 μg/ml in Ch-P A, 4.4±2.2 μg/ml in Ch-P B and 3.5±1.9 μg/ml in Ch-P C (Tab. 3). Statistically significant differences were observed between controls and Ch-P B patients (p<0.001), controls and Ch-P C patients (p<0.001), Ch-P A and Ch-P B patients (p=0.01), as well as Ch-P A and Ch-P C patients (<0.001). Conclusions. The levels of chemerin and kallistatin decrease with progression of liver damage during alcoholic liver cirrhosis. The impairment of its synthetic function leads to reductions in levels of the adipokines studied.

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Section: Discussionsupporting

confidence: 69%

Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis

Prystupa

Kiciński

Luchowska-Kocot

et al. 2019

Ann Agric Environ Med.

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“…Interestingly, serum chemerin is inversely related to Child-Pugh score, serum alanine aminotransferase and total bilirubin. Chemerin in serum is not associated with survival [61]. …”

Section: Chemerin Expression and Serum Levels In Hepatocellular Carcimentioning

confidence: 99%

Chemerin in Liver Diseases

2014

Endocrinol Metab Synd

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Chemerin is a chemoattractant protein and moreover has a role in adipogenesis, angiogenesis and glucose homeostasis. Chemerin is primarily synthesized and secreted by adipocytes and hepatocytes. Chemerin receptors chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and CC-motif chemokine receptorlike 2 (CCRL2) are all expressed in the liver suggesting that chemerin may be relevant in liver physiology and pathophysiology. Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and is the most common cause of chronic liver injury. NAFLD and chronic hepatitis C virus infection are risk factors for hepatocellular carcinoma. Hepatic and serum chemerin have been analyzed in human and rodent NAFLD, in patients with chronic hepatitis C and patients with hepatocellular carcinoma. Chemerin, GPR1 and CMKLR1 deficient mice have been used to elucidate the role of these proteins in body weight gain and glucose homeostasis. The regulation of chemerin and CMKLR1 by adipokines, hormones and cytokines relevant in liver diseases has been studied in hepatocytes. The data published so far are briefly summarized herein. Current experimental findings do not provide evidence for a crucial role of chemerin in chronic liver diseases and further research is needed to evaluate a possible protective function of this protein in hepatocellular carcinoma.

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“…Gastric cancer is one type of cancer that has been well studied for its relationship with plasma levels of chemerin [16]. Other types of cancers that have been studied for their associations with chemerin include ovarian cancer, liver cancer, lung cancer, esophageal cancer, and colorectal cancer [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer

Perumalsamy

Zin

Widodo

et al. 2017

CPD

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Impact of Serum Chemerin Levels on Liver Functional Reserves and Platelet Counts in Patients with Hepatocellular Carcinoma

Cited by 28 publications

References 39 publications

Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis

Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis

Chemerin in Liver Diseases

Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer

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