Impact of Serotonin Deficiency on Circadian Dopaminergic Rhythms
Giacomo Maddaloni,
Noemi Barsotti,
Sara Migliarini
et al.
Abstract:Physiology and behavior are structured temporally to anticipate daily cycles of light and dark, ensuring fitness and survival. Neuromodulatory systems in the brain—including those involving serotonin and dopamine—exhibit daily oscillations in neural activity and help shape circadian rhythms. Disrupted neuromodulation can cause circadian abnormalities that are thought to underlie several neuropsychiatric disorders, including bipolar mania and schizophrenia, for which a mechanistic understanding is still lacking… Show more
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