Impact of SARS‐CoV‐2 infection on risk of prematurity, birthweight and obstetric complications: A multivariate analysis from a nationwide, population‐based retrospective cohort study

Abstract

Objective: To determine the impact of maternal coronavirus disease 2019 (COVID-19) on prematurity, birthweight and obstetric complications.

The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes

“… [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] People with a SARS-CoV-2 infection during pregnancy also have worse maternal outcomes than those that do not. [6] , [10] , [11] , [12] , [13] , [14] , [15] , [16] SARS-CoV-2 infection and related complications has also disproportionately impacted minority populations and people with lower socioeconomic status. [11] , [16] , [17] , [18] , [19] In addition, SARS-CoV-2 variants have had significantly different impacts on COVID-19 severity in pregnant people.…”

“…In addition, people with COVID-19 during pregnancy universally had more severe outcomes than those that did not. [6] , [10] , [11] , [12] , [13] , [14] , [15] , [16] Pregnant people that had a COVID-19 during pregnancy have a 2.7-4.6 fold increased risk for a thrombotic event compared to pregnant people that did not have an infection ( Table 2 ). [11] , [16] They also had a 1.7-13.5 fold increased rate of ICU admission [6] , [10] , [11] , [12] , [13] , [14] , [15] , [16] and a 2.8-25.4 fold increased risk of mechanical ventilation ( Table 2 ).…”

Utility of Newborn Dried Blood Spots to Ascertain Seroprevalence of SARS-CoV-2 Antibodies Among Individuals Giving Birth in New York State, November 2019 to November 2021

“… 27 Previous studies report a reduced transplacental transfer of IgG in placental pathologies, prematurity, low-birth-weight infants, and male fetuses 28 , 29 , 30 , 31 and suggest SARS-CoV-2 infection may be a risk factor for prematurity. 32 Specific to SARS-CoV-2, transplacental transfer occurs at a higher efficiency when infection is more than 2 months before delivery but decreases if infection occurs in the third trimester. 33 , 34 , 35 The timing of COVID-19 infection during pregnancy and the duration of transplacental immunity may be useful to explain differences in SARS CoV-2 antibody reactivity with gestational age.…”

Análise Da Influência Da Covid- 19 Em Partos Prematuros: Revisão Integrativa

“…É importante enfatizar que a presença de comorbidades como a diabetes, obesidade e coinfecção bacteriana são relacionados a eventos adversos da gestação, como o trabalho de parto prematuro (SIMON et al, 2022). Notou-se uma proporção de SARS-CoV-2 em amostras placentárias, sendo que a ECA2 é fortemente expressa na interface materno-fetal envolvendo a placenta e decídua, logo supõe que o vírus pode invadir e danificar a placenta, aumentando assim sua permeabilidade placentária, provavelmente levando uma insuficiência placentária e complicações obstétricas, como o parto prematuro (JAFARI et al, 2021).…”

“…;( CHI, J. et al, 2021);(KARASEK et al, 2021) e (SIMON et al, 2022. Os partos prematuros de causas iatrogênicas foram evidenciados em 20% 2/10 (BLOISE et al, 2021) e(TURAN et al, 2020).…”