Impact of SARS-CoV-2 on pregnancy and neonatal outcomes: An open prospective study of pregnant women in Brazil

Gomez, Ursula Trovato; Francisco, Rossana Pulcineli Vieira; Baptista, Fernanda Spadotto; Gibelli, Maria Augusta Bento Cicaroni; Ibidi, Silvia Maria; Carvalho, Werther Brunow de; Paganoti, Cristiane de Freitas; Sabino, Éster Cerdeira; Silva, Lea Campos de Oliveira da; Jaenisch, Thomas; Mayaud, Philippe; Brizot, Maria de Lourdes

doi:10.1016/j.clinsp.2022.100073

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Previously, Gomez et al [24] evaluated all cases of SARS-CoV-2 among pregnant women from our institution, finding that more severe cases had larger body mass index and higher prevalence of systemic hypertension. Further, authors described that most severe cases were associated with preterm birth, fetal distress, and maternal and neonatal death as compared to mild and moderate cases [24].…”

Section: Discussionmentioning

confidence: 91%

Prone Positioning: A Safe and Effective Procedure in Pregnant Women Presenting with Severe Acute Respiratory Distress Syndrome

et al. 2022

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Prone positioning (PP) improves oxygenation and survival in patients with severe acute respiratory distress syndrome (ARDS). Data regarding feasibility and effectiveness of PP in pregnancy are lacking. This subgroup analysis of a cohort study that included mechanically ventilated pregnant women presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced ARDS who underwent PP aims to assess the efficacy and safety of PP. Ventilatory and gasometric parameters were evaluated at baseline (T0) and in prone (T1) and supine (T2) positions. Obstetric outcomes were also assessed. Sixteen cases at an average of 27.0 (22.0–31.1) gestational weeks of pregnancy were included. Obesity and hypertension were frequent comorbidities. PP was associated with a >20% increase in PaO2 levels and in PaO2/FiO2 ratios in 50% and 100% of cases, respectively. The PaO2/FiO2 ratio increased 76.7% (20.5–292.4%) at T1 and 76.9% (0–182.7%) at T2. PP produced sustained improvements in mean PaO2/FiO2 ratio (p < 0.001) and PaCO2 level (p = 0.028). There were no cases of emergency delivery or suspected fetal distress in pregnancies ≥25 weeks during the 24 h period following PP. PP is safe and feasible during pregnancy, improving PaO2/FiO2 ratios and helping to delay preterm delivery in severe ARDS.

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Section: Discussionmentioning

confidence: 91%

Prone Positioning: A Safe and Effective Procedure in Pregnant Women Presenting with Severe Acute Respiratory Distress Syndrome

et al. 2022

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“…Unexpectedly, we also found that the prevalence of primigravida was significantly higher in positive COVID-19 women compared with age-matched healthy controls. A previous study indicated that primigravida was not associated with severe maternal outcomes among positive pregnant women (Vouga et al, 2021) whereas Trovato-Gomez et al reported that primigravida decreased the risk of severe COVID-19 (Gomez et al, 2022). These inconclusive findings might be due to differences in gestational age and the severity of the diseases, since in the study of Vouga et al, all pregnant women were tested for SARS-CoV-2 infection at any stage of gestation (Vouga et al, 2021).…”

Section: Discussionmentioning

confidence: 98%

Impact of SARS-COV-2 Infection on Maternal, Obstetric and Neonatal Outcomes in a Cohort of Vaccinated Women: A Pilot Study

Cruz-Calvente,

Rueda-Medina,

Gil-Gutiérrez

et al. 2024

Biological Research For Nursing

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We aimed to investigate the impact of COVID-19 infection on maternal characteristics and obstetric and neonatal outcomes in a cohort of women in labor previously vaccinated who tested positive for SARS-CoV-2 infection, compared to aged-matched healthy controls. A retrospective case-control study was conducted among 66 women in labor. Clinical data were obtained from medical records. The attendance rates at childbirth and parenting classes, as well as the implementation of a birth plan, were significantly lower in the COVID-19 infection group (6.1% vs. 48.5%, <0.001; 6.1% vs. 33.3%, p = .005, respectively). Women with COVID-19 had a higher prevalence of prolonged postpartum hospital stay (33.3% vs. 9.1%, p = .016), and significantly higher prevalence of spontaneous preterm birth (27.3% vs. 1.09%, p = .006). Breastfeeding within the first 24 hr was also lower in women with COVID-19 (72.7% vs. 97.0%, p = .006). Maternal characteristics and neonatal outcomes are influenced by COVID-19 infection in vaccinated women. Complications include spontaneous preterm birth, prolonged postpartum hospital stay, and lack of breastfeeding within the first 24 hr. Childbirth education, parenting classes and implementing a birth plan may be associated with a decreased risk of COVID-19 infection.

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“…Placental findings were compared with clinical parameters of the severity of COVID-19, and the cases were divided into three groups according to the severity of the disease: mild, women with no symptoms or when there was no need for ventilatory support; moderate, symptomatic women with need for hospitalization (SpO2 <94% and/or respiratory rate >24 breaths per minute) and in the hospital admission with the need for supplemental oxygen delivered by a simple catheter and severe was defined as a hospital admission with the need for admission in the ICU (i.e., supplemental oxygen delivered in forms other than simple catheter [e.g., venturi mask] and/or organ involvement), using an adapted version of the classification proposed by the Ministry of Health of Brazil [ 15 , 16 ]. The evaluated obstetric parameters were: oligohydramnios (defined as amniotic fluid index <5), preeclampsia, and gestational diabetes.…”

Section: Methodsmentioning

confidence: 99%

Placental pathological findings in coronavirus disease 2019: Perinatal outcomes

et al. 2022

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Impact of SARS-CoV-2 on pregnancy and neonatal outcomes: An open prospective study of pregnant women in Brazil

Cited by 8 publications

References 28 publications

Prone Positioning: A Safe and Effective Procedure in Pregnant Women Presenting with Severe Acute Respiratory Distress Syndrome

Prone Positioning: A Safe and Effective Procedure in Pregnant Women Presenting with Severe Acute Respiratory Distress Syndrome

Impact of SARS-COV-2 Infection on Maternal, Obstetric and Neonatal Outcomes in a Cohort of Vaccinated Women: A Pilot Study

Placental pathological findings in coronavirus disease 2019: Perinatal outcomes

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