Impact of Sarcopenic Obesity on Long-Term Cancer Outcomes and Postoperative Complications After Gastrectomy for Gastric Cancer

Juez, Luz Divina; Priego, Pablo; Bajawi, Mariam; Cuadrado, Marta; Blázquez, Luis Alberto; Sánchez-Picot, Silvia; Galindo, Julio; Blázquez, Javier; Fernández‐Cebrián, José María; Botella-Carretero, José I.

doi:10.1007/s11605-022-05492-w

Cited by 10 publications

(10 citation statements)

References 32 publications

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“…In the context of anastomotic leak, preoperative identification of SO proved valuable in predicting gastric leaks after sleeve gastrectomy [ 18 ] and increased the risk of pancreatic fistula after pancreaticoduodenectomy [ 19 ]. Additionally, SO was associated with severe postoperative complications and poorer long-term survival after gastrectomy for gastric cancer [ 10 ]. In colon cancer surgery, our study observed an almost threefold increase in the rate of anastomosis dehiscence in the SO group.…”

Section: Discussionmentioning

confidence: 99%

“…In determining the obesity cut-off values, we adhered to the criteria outlined by Juez et al Specifically, for males, the identified cut-off values for VFA and SFA were 153.8 and 128.6, respectively. Conversely, for females, the corresponding cut-off values were 121.05 for VFA and 163.17 for SFA [ 10 ]. VFA was selected as the representative measure of body fat due to its superior sensitivity and specificity.…”

Section: Methodsmentioning

confidence: 99%

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Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Bajawi,

Corral,

Blázquez

et al. 2024

Langenbecks Arch Surg

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Objective This study aimed to investigate the influence of sarcopenic obesity on anastomotic leak following elective colon resection for non-metastatic colon cancer. Secondary outcomes included overall morbidity, mortality and length of hospital stay. Methods This retrospective observational study, conducted at a colorectal surgery referral centre, spanned from January 1, 2015, to January 1, 2020. A total of 544 consecutive patients who underwent elective colon resection were included in the analysis, excluding patients with rectal cancer, urgent surgery, absence of anastomosis, lack of imaging, multivisceral resections and synchronic tumours. Results Postoperative complications were observed in 177 (32.3%) patients, with 51 (9.31%) classified as severe (Clavien-Dindo > II). Sarcopenic obesity was identified in 9.39% of the sample and emerged as an independent predictor of increased overall morbidity [OR 2.15 (1.14–3.69); p = 0.016] and 30-day mortality [OR 5.07 (1.22–20.93); p = 0.03] and was significantly associated with the development of anastomotic leak [OR 2.95 (1.41–6.18); p = 0.007]. Furthermore, it increased the risk of reoperation and was linked to a prolonged length of hospital stay. Conclusions CT-measured sarcopenic obesity demonstrates a discernible correlation with an elevated risk of postoperative morbidity and mortality in the context of colon cancer surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Bajawi,

Corral,

Blázquez

et al. 2024

Langenbecks Arch Surg

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“…10 Alterations in BC have also been linked to unfavorable prognosis and reduced long-term survival in various cancer types, including HCC, gastric cancer, and breast cancer. [11][12][13] Nevertheless, the impact of fluctuations in BC on postoperative complications in patients diagnosed with pCCA remains poorly understood. Until now, only limited research has explored the potential significance of preoperative BC in predicting postoperative complications among patients with pCCA.…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in BC, including body mass index (BMI), sarcopenia, myosteatosis, visceral obesity, sarcopenic obesity, and visceral to subcutaneous adipose tissue ratio (VSR) serve as prognostic markers in a variety of clinical settings including the progression of oncological and liver disease 10 . Alterations in BC have also been linked to unfavorable prognosis and reduced long‐term survival in various cancer types, including HCC, gastric cancer, and breast cancer 11–13 …”

Section: Introductionmentioning

confidence: 99%

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Body composition is associated with postoperative complications in perihilar cholangiocarcinoma

Wang,

Mantas,

Heij

et al. 2024

Cancer Medicine

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BackgroundPerihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients with pCCA. Changes in body composition (BC) have been shown to impact the prognosis of various types of tumors. Therefore, our study aimed to investigate the correlation between BC, postoperative complications and oncological outcome in patients with pCCA.MethodsAll patients with pCCA who underwent curative‐intent surgery for pCCA between 2010 and 2022 were included in this analysis. BC was assessed using preoperative computed tomography and analyzed with the assistance of a 3D Slicer software. Univariate and multivariate binary logistic regression analyses were conducted to examine the relationship between BC and clinical characteristics including various measurements of postoperative complications and Cox regressions and Kaplan–Meier analysis to evaluate oncological risk factors in the study cohort.ResultsBC was frequently altered in patients undergoing curative‐intent liver resection for pCCA (n = 204) with 52.5% of the patients showing obesity, 55.9% sarcopenia, 21.6% sarcopenic obesity, 48.5% myosteatosis, and 69.1% visceral obesity. In multivariate analysis, severe postoperative complications (Clavien‐Dindo ≥3b) were associated with body mass index (BMI) (Odds ratio (OR) = 2.001, p = 0.024), sarcopenia (OR = 2.145, p = 0.034), and myosteatosis (OR = 2.097, p = 0.017) as independent predictors. Furthermore, sarcopenia was associated with reduced overall survival (OS) in pCCA patients (sarcopenia vs. no‐sarcopenia, 21 months vs. 32 months, p = 0.048 log rank).ConclusionsBC is highly associated with severe postoperative complications in patients with pCCA and shows tendency to be associated impaired overall survival. Preoperative assessment of BC and interventions to improve BC might therefore be key to improve outcome in pCCA patients undergoing surgical therapy.

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Sarcopenic obesity in older adults: a clinical overview

Prado,

Batsis,

Donini

et al. 2024

Nat Rev Endocrinol

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Impact of Sarcopenic Obesity on Long-Term Cancer Outcomes and Postoperative Complications After Gastrectomy for Gastric Cancer

Cited by 10 publications

References 32 publications

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Impact of CT-measured sarcopenic obesity on postoperative outcomes following colon cancer surgery

Body composition is associated with postoperative complications in perihilar cholangiocarcinoma

Sarcopenic obesity in older adults: a clinical overview

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