Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory hallucinations

Briend, Frederic; Leroux, Elise; Delcroix, Nicolas; Razafimandimby, Annick; Dollfus, Sonia

doi:10.1016/j.schres.2017.01.049

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…We cannot completely rule out the possibility that the cTBS intervention led to some fast reorganization of the decision network following M1 disruption. According to this idea, M1 might still be part of the network involved in the deliberation process but some compensatory mechanisms may have occurred in this network following M1 disruption, leading to similar decision behaviors after M1 and sham cTBS (Bestmann et al, 2004;Briend et al, 2017;Cash et al, 2017;Derosiere et al, 2017a;Rastogi et al, 2017). One solution to tackle this issue in the future would be to exploit online rTMS techniques (Duque et al, 2010(Duque et al, , 2013, which could allow one to perturb neural activity at a specific moment during the decision process, leaving less time for compensatory mechanisms to occur.…”

Section: Discussionmentioning

confidence: 99%

M1 disruption delays motor processes but not deliberation about action choices

Derosière

Thura

Cisek

et al. 2018

Preprint

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Decisions about actions typically involve a period of deliberation that ends with the commitment to a choice and the motor processes overtly expressing that choice. Previous studies have shown that neural activity in sensorimotor areas, including the primary motor cortex (M1), correlates with deliberation features during action selection. Yet, the causal contribution of these areas to the decision process remains unclear. Here, we investigated whether M1 determines choice commitment, or whether it simply reflects decision signals coming from upstream structures and instead mainly contributes to the motor processes that follow commitment. To do so, we tested the impact of a disruption of M1 activity, induced by continuous theta burst stimulation (cTBS), on the behavior of human subjects in (1) a simple reaction time (SRT) task allowing us to estimate the duration of the motor processes and (2) a modified version of the tokens task (Cisek et al., 2009), which allowed us to estimate subjects' time of commitment as well as accuracy criterion. The efficiency of cTBS was attested by a reduction in motor evoked potential amplitudes following M1 disruption, as compared to those following a sham stimulation. Furthermore, M1 cTBS lengthened SRTs, indicating that motor processes were perturbed by the intervention. Importantly, all of the behavioral results in the tokens task were similar following M1 disruption and sham stimulation, suggesting that the contribution of M1 to the deliberation process is negligible. Taken together, these findings indicate that M1 contribution is downstream of the decision process. New and noteworthyDecisions between actions are ubiquitous in the animal realm. Deliberation during action choices entails changes in the activity of the sensorimotor areas controlling those actions, but the causal role of these areas is still often debated. Using continuous theta burst stimulation, we show that disrupting the primary motor cortex (M1) delays the motor processes that follow instructed commitment but does not alter volitional deliberation, suggesting that M1 contribution is downstream of the decision process.

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Section: Discussionmentioning

confidence: 99%

M1 disruption delays motor processes but not deliberation about action choices

Derosière

Thura

Cisek

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…used real‐time magnetic resonance imaging (rtfMRI) to show that neural feedback therapy can enhance the neural connections between the language network and default mode network, effectively alleviating the symptoms of AVHs (Zweerings et al., 2019). Similarly, rTMS has been shown to improve the functioning of language‐related networks and internal language networks (Bais et al., 2017), leading to the alleviation of AVH symptoms (Briend et al., 2017).…”

Section: Depressive Symptoms In Schizophreniamentioning

confidence: 99%

Brain imaging features in schizophrenia with co‐occurring auditory verbal hallucinations and depressive symptoms—Implication for novel therapeutic strategies to alleviate the reciprocal deterioration

et al. 2020

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Background Auditory verbal hallucinations (AVHs) and depressive symptoms are highly prevalent in schizophrenia, and recent progress has been made in understanding the reciprocal deterioration of both symptoms through structural and functional brain imaging studies. To date, there is limited literature on this topic. In this review, we synthesized the recent literature on the neuroimaging features of schizophrenia patients with concurrent AVHs and depressive symptoms. Methods A literature search was conducted with the major databases using the keywords, mainly including schizophrenia, AVHs, depression, neuropsychiatric disorders, brain imaging, and magnetic resonance imaging. Results The existing studies have shown that AVHs and depressive symptoms reciprocally deteriorate in patients with schizophrenia, which has challenged the conventional treatment of the disease. Interestingly, repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) therapies have emerged as two efficacious brain stimulation treatments that can normalize the brain regions associated with the symptoms, as shown through functional and structural brain imaging studies. In light of these important findings, there is an urgent need to conduct in‐depth neuronal mechanistic studies to identify targets for stimulation therapy. Conclusions These new findings may elucidate the pathological mechanisms underlying schizophrenia with concurrent AVHs and depressive symptoms. Furthermore, this review has important clinical implications for developing novel therapeutic strategies to alleviate the reciprocal deterioration AVHs and depressive symptoms of schizophrenia patients.

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“…In the case of Mr. WF, additionally to higher brain activation in the left primary auditory cortex (responsible for basal acoustic processing), the thalamus (filtering of sensory information) was also hyperactivated in the AVH condition, suggesting extended thalamocortical connectivity (43). Recent findings indicate that rTMS treatment when applied over the TP3-situated anatomically close to the temporoparietal junction-may impact the contribution of distant brain regions within the brain circuitry involved in language processing (44) without changing the functional coupling of them (45). This effect might provide the improvement of AVH symptoms in SZ patients (45).…”

Section: Possibly Common Pathway and Distant Originsmentioning

confidence: 99%

“…Recent findings indicate that rTMS treatment when applied over the TP3-situated anatomically close to the temporoparietal junction-may impact the contribution of distant brain regions within the brain circuitry involved in language processing (44) without changing the functional coupling of them (45). This effect might provide the improvement of AVH symptoms in SZ patients (45). A similar mechanism may play a role in patients with VLOSLP.…”

Section: Possibly Common Pathway and Distant Originsmentioning

confidence: 99%

Theta-Burst Stimulation for Auditory-Verbal Hallucination in Very-Late-Onset Schizophrenia-Like Psychosis—A Functional Magnetic Resonance Imaging Case Study

et al. 2020

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Background: Treating very-late-onset (>60 years) schizophrenia-like psychosis (VLOSLP) is challenging. Age-related factors in elderly individuals (e.g., metabolism, medication side effects, drug-interaction, somatic morbidity) may adversely affect treatment. Novel therapeutic approaches are needed to ensure the favorable therapeutic outcome in geriatric patients. Previously, theta-burst stimulation (TBS), a novel form of repetitive transcranial magnetic stimulation, was reported being beneficial in the treatment for auditory-verbal hallucination (AVH) in young and middle-aged schizophrenia (SZ) patients. Case Presentation: Here we present a case of a male patient aged 73. His first psychotic episode manifested with paranoid delusions, auditory-verbal and tactile hallucinations at the age of 66, and first remitted following a second-generation antipsychotics (SGA). Years later, after a relapse the AVH did not respond to previously effective olanzapine, whereas its augmentation with an inhibitory TBS over the left temporal lobe led to a stable remission. During his second relapse, TBS was again capable of facilitating therapeutic action of SGA in the same patient. Extending to our clinical observation, a series of functional MRI scans employing a tonal activation paradigm depicted altered auditory processing during AVH as well as brain activation change during remission. Conclusions: The current case might indicate to favorable effects of combining conventional medicament therapy and non-invasive brain stimulation techniques for elderly patients. Also, we speculate that despite obviously distinct etiologies, the present functional imaging and clinical observation may also demonstrate a possible common pathophysiological pathway underlying AVH in VLOSLP and SZ.

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Impact of rTMS on functional connectivity within the language network in schizophrenia patients with auditory hallucinations

Cited by 15 publications

References 21 publications

M1 disruption delays motor processes but not deliberation about action choices

M1 disruption delays motor processes but not deliberation about action choices

Brain imaging features in schizophrenia with co‐occurring auditory verbal hallucinations and depressive symptoms—Implication for novel therapeutic strategies to alleviate the reciprocal deterioration

Theta-Burst Stimulation for Auditory-Verbal Hallucination in Very-Late-Onset Schizophrenia-Like Psychosis—A Functional Magnetic Resonance Imaging Case Study

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