Impact of RT1.C-encoded MHC antigens on host-versus-graft and graft versus-host reactions in a model of small bowel transplantation in the rat

Fändrich, F.; Zhu, Xiaofeng; Dresske, Bettina; Papachrysanthou, A.; Exner, Beate G.; Chambers, William H.

doi:10.1016/s0041-1345(97)00034-1

Cited by 5 publications

(1 citation statement)

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“…Review of the literature indicates the presence of rat strain differences in some areas of research, but not in others. Strain differences have been reported in the development of graft-vs.-host disease after bone marrow transplantation, 9 small bowel transplantation, 10 susceptibility to arthritogen-induced arthritis, 11 and autotomy following sciatic nerve transection. 12,13 Other studies have reported an absence of strain difference in anesthetic and convulsant requirements of inhaled compounds 14 and in peripheral-nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

Rat-Strain Differences in Recovery Following Peripheral-Nerve Allotransplantation

Calvert¹,

Doolabh²,

Grand³

et al. 2001

J reconstr Microsurg

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The rat model is commonly utilized in peripheral nerve research. Due to the short length of the rat limb and the animal's inherent neuroregenerative capacity, the timing of assessment of nerve regeneration is critical, and significant differences between groups can be lost if assessment is done too late. Additionally, the comparison of data from different rat-strain combinations has been questioned. This study better defines the time course of recovery after peripheral nerve grafting, and examines differences between Buffalo (BUF), Lewis (LEW), and ACI rats. Tibial-nerve isografts and allografts were performed and harvested at 6, 8, 10, or 14 weeks. Histomorphometry documented a statistically significant difference in the ACI/LEW and LEW/LEW combination at 10 weeks. No strain differences in graft rejection were noted. The optimal time to assess for histomorphometric differences in the ACI/LEW and LEW/LEW combination is at 10 weeks postoperatively.

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