Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections

Sun, Hongwei; Sun, Jiyang; Ji, Wei; Hao, Chuangli; Ya, Yan; Chen, Zhengrong; Wang, Yuqing

doi:10.1093/tropej/fmy057

Cited by 25 publications

(28 citation statements)

References 31 publications

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“…The frequency of HBoV co-detection is in line with Zhou et al (52%) and Ljubin-Sternak et al [2,17], higher than the one found by Sun et al [18] and only a bit lower than other studies [5,7,19]. In infants hospitalized for an acute respiratory infection, Calvo et al in one study detected HBoV in combination with other viruses in 64.6% of children and in another study in 75% of the patients [5,19].…”

Section: Discussionsupporting

confidence: 81%

“…Considering only infants hospitalized for bronchiolitis, we confirmed our previous findings that the RSV-HBoV co-detection was associated with higher severity of the disease. Other studies confirmed the higher clinical severity presentation of RSV-HBoV co-infection in infants with respiratory infection [18]. A HBoV co-detection was registered in 42.1% patients with an acute episode of wheezing.…”

Section: Discussionsupporting

confidence: 61%

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Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

et al. 2019

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Background The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled yet. We aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in co-infection. Methods We retrospectively reviewed data from 60 children (median age of 6.2 months, range 0.6-70.9) hospitalized for acute respiratory symptoms, with HBoV detected from a respiratory sample, using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV), influenza virus A and B, human coronavirus OC43, 229E, NL-63 and HUK1, adenovirus, rhinovirus, parainfluenza virus1-3, and human metapneumovirus).Results HBoV was detected alone in 29 (48.3%) patients, while in co-infection with other viruses in 31 patients (51.7%), with a peak between December and January. Among the 60 patients, 34 were bronchiolitis, 19 wheezing, 3 pneumonia, 2 upper respiratory tract infection, and 2 whooping cough. Seven children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory failure. No differences was observed in age, family history for atopy and/or asthma, clinical presentations, chest X-ray, or laboratory findings in children with HBoV alone vs. multiple viral detection. RSV was the most frequently co-detected virus (61.3%). When compared with HBoV detection alone, the co-detection of RSV and HBoV was associated with male sex (P = 0.013), younger age (P = 0.01), and lower blood neutrophil count (P = 0.032). Conclusions HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection. A cause-effect relationship between HBoV and respiratory infection is not clear, so further studies are needed to clarify this point.the cause-effect relationship between HBoV detection and respiratory infections cannot be achieved, yet based on our data and further studies are needed to clarify if HBoV can play a pathogenetic role in respiratory diseases of children.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 61%

Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

et al. 2019

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“…Our findings of co-infections are in line with results obtained by other research groups. For example, a group from China reported that RSV and HRV were the most frequently detected co-infections with HBoV1 (Sun et al, 2018). Also in other studies, RSV, HRV, AdV, MPV, and HEV are mentioned as the most common co-infections with HBoV1 (Wang et al, 2010;Calvo et al, 2016;Liu et al, 2018).…”

Section: Discussionmentioning

confidence: 94%

Presence of Human Bocavirus 1 and other Respiratory Viruses in Children with Lower Respiratory Tract Infection in Latvia

Vilmane

Ziemele

Rasa

et al. 2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Lower respiratory tract infection (LRTI) is the major cause of morbidity and mortality of children in the world. In addition to respiratory syncytial virus, influenza virus types A and B, parainfluenza types 1, 2 and 3, and adenoviruses, several new respiratory viruses associated with LRTI were discovered in the 21st century. These are metapneumovirus, coronaviruses NL63 and HKU1, parainfluenza virus type four and human bocavirus one (HBoV1). HBoV1 was discovered in 2005 and is considered as the fourth most prevalent respiratory virus worldwide. However, the high frequency of co-infections detected together with HBoV1 raises doubt about whether HBoV1 is a true pathogen or just a bystander. This is the first study aimed to determine the presence of HBoV1 and 18 other respiratory viruses in nasopharyngeal aspirates (NPA) of children with LRTI in Latvia. Using multiplex real-time polymerase chain reaction method, the HBoV1 genomic sequence was detected in 60.0% of NPA samples, showing that HBoV1 prevalence is high among children with LRTI in Latvia. HBoV1 mono-infection was revealed in 6.67%. The most common co-infections associated with HBoV1 were rhinovirus, adenovirus, respiratory syncytial virus A and B, metapneumovirus, and enterovirus.

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“…Seasonal distribution of HBoV is not well defined, and might be affected by geographic areas. Some studies showed that high prevalence of HBoV infections occurred in the winter and spring [21,22,23,24], while other studies showed high prevalence in the early summer and late spring [23,24,25]. However, clear seasonal activity was not observed in some studies.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous set of studies conducted by our laboratory the prevalence and circulation pattern of several respiratory viruses were studied. HBoV studies in Saudi Arabia have only reported in few studies [19,20,25]. There is no published data on the complete Vp1 and VP2 gene sequences of HBoV-1 in Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

Human Bocavirus in Saudi Arabia: Molecular Epidemiology and Co-Infections Among Children With Acute Respiratory Tract Infections

Hamed

Farrag

Amer

et al. 2020

Preprint

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Background During the last few years since HBoV discovery, the virus has attracted less attention and appeared to be one of the most common acute respiratory tract pathogens in children. However, few studies focused on genetic characterization and epidemiology of HBoV in Saudi Arabia, leading us to evaluate the molecular epidemiology of HBoV strains among children with ARI. This study was designed to study the epidemiological, genetic diversity and circulation pattern of HBoV among hospitalized children (< 7 years) due to acute respiratory tract infection (ARTI) during two consecutive years. Nasopharyngeal aspirate (NPA) samples (n=196) were collected. HBoV and co-infection with other respiratory pathogens were identified using qRT-PCR. Positive samples were subsequently subjected to amplify full-length of VP1/VP2 gene, followed by sequencing and phylogenetic analyses. Results Our data showed that 3.4% (2014/2015) and 11.3% (2015/2016) of children hospitalized due to acute respiratory infections (ARI) were infected by HBoV-1. We have shown that HBoV-1 was detected year-round. HBoV-1 also was co-detected with one or multiple other respiratory viruses. Phylogenetic analysis of complete HBoV VP1/2 sequences showed no nucleotide variation and the circulation of HBoV-1. The multisequence analysis showed complete identity between HBoV isolated from 2014/2015 and 2015/2016, suggesting no genetic variability among the local circulating HBoV-1 genotypes. Our data reveal that genetically conserved HBoV-1 is circulating in Saudi Arabia. Conclusions The multisequence analysis showed complete identity between HBoV-1 isolated from 2014/2015 and 2015/2016, suggesting no genetic variability among the local circulating HBoV-1 genotypes. Our data reveal that genetically conserved HBoV-1 is circulating year-round in Saudi Arabia.

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Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections

Abstract: HBoV coinfection with RSV increases HBoV infection severity.

Cited by 25 publications

References 31 publications

Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

Presence of Human Bocavirus 1 and other Respiratory Viruses in Children with Lower Respiratory Tract Infection in Latvia

Human Bocavirus in Saudi Arabia: Molecular Epidemiology and Co-Infections Among Children With Acute Respiratory Tract Infections

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