Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

Schindlbeck, Katharina A.; Becker, Janine; Berger, Felix; Mehl, Arne; Rewitzer, Charlotte; Geffe, Sarah; Koch, Peter; Preiß, J; Siegmund, Britta; Maul, Jochen; Marzinzik, Frank

doi:10.1007/s00384-016-2681-8

Cited by 14 publications

(13 citation statements)

References 38 publications

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“…Sleep problems of patients include short sleep time, difficulty in falling asleep, increased number of WASO, etc (26). Summarizing their research, the factors affecting sleep quality of IBD patients include disease active period, unemployment, female, hormone therapy, restless legs syndrome, fatigue, anxiety, inflammatory factors, and so on (16,(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Sleep Characteristics and Influencing Factors of Sleep Quality in Patients With Inflammatory Bowel Disease-Peripheral Arthritis

Zhang¹,

Xu³

et al. 2020

Front. Med.

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Background: Patients with inflammatory bowel disease-peripheral arthritis (IBD-PA) often accompany by sleep problems, but few studies have used polysomnography to investigate the objective sleep characteristics of IBD-PA. Methods: Patients in IBD-PA group, inflammatory bowel disease (IBD) group, healthy control (HC) group were examined by polysomnography (PSG) and the sleep characteristics were compared. PSG and Pittsburgh Sleep Quality Scale (PSQI) indices were compared between active and remission IBD-PA patients. The correlation between disease activity and sleep quality in IBD-PA patients was analyzed. The influencing factors of sleep efficiency of IBD-PA patients were analyzed. Results: The total sleep time (TST), rapid-eye-movement sleep (REM) time, slow wave sleep (S3 + S4) and sleep efficiency (SE) in the IBD-PA group were significantly less than those in the HC group and IBD group (P < 0.05), while the number and time of wake after sleep onset (WASO) and sleep latency (SL) were significantly longer than those in the HC group and IBD group (P < 0.05). To IBD-PA patients, the disease activity was negatively related to sleep quality. There was a significant difference in SE, the number of WASO, S1, S3+S4 of PSG, as well as the PSQI total score between active and remission patients. Abdominal pain, joint pain, depression, and C-reactive protein were the influencing factors of sleep efficiency. Conclusions: The sleep quality of patients with IBD was poor than the control group, and that of patients with IBD-PA was even worse. Therefore, sleep management should be included in IBD management.

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Section: Discussionmentioning

confidence: 99%

Sleep Characteristics and Influencing Factors of Sleep Quality in Patients With Inflammatory Bowel Disease-Peripheral Arthritis

Zhang¹,

Xu³

et al. 2020

Front. Med.

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“…Various studies showed the increased frequency of RLS and its association with poor sleep quality in many diseases such as chronic renal failure, [26] fibromyalgia, [27] ankylosing spondylitis, [28] lumbar radiculopathy, [29] inf lammatory bowel disease, [30] or primary biliary cirrhosis. [31] However, there exist only a small number of studies which investigate the relationship between RLS and allergic diseases in adults, but not in children.…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome in children with allergic rhinitis: A comparative study on frequency, severity and sleep quality

Filiz¹

2018

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the frequency and severity of restless legs syndrome (RLS) and its relationship with sleep quality in children with allergic rhinitis (AR) with the hypothesis that comorbid RLS may be an additional causative factor of sleep disturbances in pediatric AR. Patients and methods: A total of 143 children with AR (aged 8-18 years) and 144 healthy control subjects (aged 8-18 years) were included. The diagnosis of AR was established on history, clinical examination and skin prick test according to the Allergic Rhinitis and its Impact on Asthma guidelines. Presence of RLS was determined using the International RLS study group (IRLSSG) criteria. The severity of RLS was assessed using the IRLSSG rating scale. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI). Results: Thirteen patients (9.1%) in AR group, and six children (4.2%) in control group had RLS (p=0.159). The frequency of RLS in AR group was higher than two folds when compared to the control group; however, the difference was not statistically significant. Restless legs syndrome severity score was significantly higher in AR group than control group (15.00 [11-20] and 11.00 [10-16] respectively, p=0.046). Total PSQI scores were similar between groups. Also, no significant differences were observed in total PSQI scores of AR patients with or without RLS. Conclusion: Restless legs syndrome was not more common but was more severe in children with AR. There was no evidence that RLS has an obvious effect on sleep quality in children with AR.

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“…In an adult Japanese study, Uemura et al [22] reported that QoL scores were significantly lower in patients with any sleep disturbance than in patients without sleep disturbance. Another study in adults showed that sleep disorders, which included longer sleep latency, shorter sleep duration and fatigue, are characteristic symptoms of restless legs syndrome in IBD patients, resulting in worse QoL [23]. This pediatric study showed that the adolescent sleep questionnaires significantly correlated with QoL and psychosocial functioning scores.…”

Section: Discussionmentioning

confidence: 78%

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

Jarasvaraparn¹,

Zlomke²,

Vann³

et al. 2019

J. pediatr. gastroenterol. nutr.

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Background: Pediatric patients with inflammatory bowel disease (IBD) are at risk for psychiatric symptoms that impact quality of life (QoL) and psychosocial functioning. Sleep disturbance has been reported to impose adverse effects on host defense mechanisms by affecting the magnitude and characteristics of the inflammatory response. The current study sought to assess the relationships among sleep disturbance, QoL, and psychosocial functioning in children with IBD. Methods: Pediatric IBD patients completed multiple measures of sleep and daytime functioning as well as measures of QoL and psychosocial functioning. The parents completed complementary measures of sleep, QoL, and psychosocial functioning. The HRQOL results for subjects with IBD were compared to a healthy control group. Results: Fifty-three children with pediatric IBD and their parents were enrolled in the study. QoL was positively associated with sleep quality, based on significant negative correlations between QoL and both sleep quality and daytime sleepiness scales (r = −0.62, −0.57; p value <0.001, respectively). Patients with CD reported significantly better QoL and psychosocial functioning than patients with UC. The QoL was similar between IBD patients and healthy controls. Conclusions: The present study suggests that a positive association exists between sleep functioning and QoL in pediatric patients with IBD. Patients with pediatric IBD should be screened for sleep disturbance, QoL and psychosocial functioning. Prevention and intervention strategies of sleep disturbance aimed at improving QoL and psychosocial functioning in children with IBD should be developed and evaluated.

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Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

Cited by 14 publications

References 38 publications

Sleep Characteristics and Influencing Factors of Sleep Quality in Patients With Inflammatory Bowel Disease-Peripheral Arthritis

Sleep Characteristics and Influencing Factors of Sleep Quality in Patients With Inflammatory Bowel Disease-Peripheral Arthritis

Restless legs syndrome in children with allergic rhinitis: A comparative study on frequency, severity and sleep quality

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

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