Impact of respiratory viruses on the course of chronic obstructive pulmonary disease: Towards optimizing treatment

Kalyuzhin, O. V.; Челенкова, И. Н.; Понежева, Ж.Б.

doi:10.17116/terarkh201587398-104

Cited by 2 publications

(1 citation statement)

References 43 publications

(46 reference statements)

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“…It is not surprising that there is an intensive increase in the incidence of diseases of the respiratory system, especially chronic ones [2]. In addition, it should be taken into account that the course of the co-infection will depend on the initial state of the components of the respiratory system, which has been especially important in the recent years [3][4][5]. Toxic agents cause damage to any tissue.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

Protsko,

Shishkina,

Naumova

et al. 2023

ArveMED

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Aim: To study the influence of macrophages or CD68 positive cells on the processes of proliferation and apoptosis in the respiratory system. Materials and Methods: Experimental modeling of chronic hypoxic hypoxia in combination with inhalation of natural gas was carried out on 133 outbred male rats. Hypoxia was simulated using special seed chambers and natural gas from the Astrakhanskoye Conventional Gas Field at a concentration of 3 mg/m3. The animals were placed under these conditions four hours a day for five days a week for four months. The animals were removed once a month - after 30, 60, 90 and 120 days. The activity of proliferation and apoptosis processes was studied by immunohistochemical method, followed by analysis of the expression of the proliferation marker Ki67, the apoptosis marker p53. The morphofunctional activity of macrophages was determined by the distribution of CD68 positive cells in structural components of respiratory system and the cytokine content in arterial blood taken from the abdominal aorta, that is, at the exit from lungs. Results: With the increase of the chronic experiment duration, the formation of two types of multidirectional morphological changes was revealed: thinning and stretching of the interalveolar septa, an increase in the volume of the alveoli in the peripheral parts of the lungs, and thickening of the interalveolar septa due to increased blood supply and edema-swelling in the early stages and proliferation of fibrous connective tissue in later periods; whereas the diameter and volume of the alveoli became smaller. Under chronic hypoxia combined with the action of natural gas, in all studied structures of the respiratory system there was an increase in the activity of CD68 positive cells. This is manifested by an increase in their number and activation of spontaneous and induced production of the pro-inflammatory cytokine TNFα. Besides, in areas of the lungs with changes in the type of atelectasis, an increase in the expression of the proliferation marker Ki67 and the apoptosis marker p53 was revealed. The latter is most likely associated with a deterioration in blood supply and oxygenation of these areas and the migration of leukocyte and fibroblast cells here, followed by their proliferation and formation pulmonary fibrosis. In areas with emphysematous changes, a decrease in the content of Ki67 positive cells was revealed with a simultaneous increase in the number of p53 positive cells. Conclusion: Thus, it is possible to determine a direct relationship between the increase in the morphofunctional activity of CD68 positive cells and the intensity of proliferation and apoptosis processes in the structural components of the respiratory system under chronic hypoxia combined with natural gas inhalation.

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Section: Introductionmentioning

confidence: 99%

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

Protsko,

Shishkina,

Naumova

et al. 2023

ArveMED

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New treatment options for acute respiratory viral infections

2022

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The treatment of acute respiratory viral infection remains an urgent public health problem. There are currently a limited number of drugs used for the treatment and prevention of this pathology with proven efficacy and safety. According to current views in the field of immunology, the most important role in immune protection against both viruses and bacteria is played by molecules and receptors that form the so-called “immune synapse”, understood as a contact of cells involved in the detection of an antigen and triggering the subsequent chain of reactions to destroy it. A complex antiviral drug that has the ability to modulate rather than block the activity of its target molecules is a product containing technologically treated antibodies to interferon gamma, CD4 and domains of the main histocompatibility complex. The combined action of its components helps to reduce the infection load on the body, reduce the severity of symptoms of SARS during the first days, reduce the duration of the infectious disease. The pharmacological effect of the drug is achieved by acting on the key molecules and receptors involved in the recognition of pathogens of both viral and bacterial origin by the immune system. In addition, the product has a direct effect on IFN-γ, which results in stopping the multiplication of viruses and protecting healthy cells from infection. The use of the antibody-based drug reduces the risk of complications and helps to increase the body’s resistance to the main pathogens of viral and bacterial infections of the respiratory tract. According to the results of clinical trials, this drug has shown high efficacy and safety in the treatment of acute respiratory viral infections (ARI) in adults. The use of antibody-based medicine in paediatric acute respiratory infections and COVID-19 treatment in an outpatient setting is currently being investigated in multicentre, double-blind, placebo-controlled randomised trials.

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Impact of respiratory viruses on the course of chronic obstructive pulmonary disease: Towards optimizing treatment

Cited by 2 publications

References 43 publications

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

New treatment options for acute respiratory viral infections

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