Impact of Respiratory Virus Infections on Persons With Chronic Underlying Conditions

Glezen, W. Paul; Greenberg, Stephen B.; Atmar, Robert L.; Piedra, Pedro A.; Couch, Robert B.

doi:10.1001/jama.283.4.499

Cited by 496 publications

(329 citation statements)

References 37 publications

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“…In children the majority of illness are upper respiratory, but 15% of cases are associated with lower respiratory tract disease (30). Although clinical manifestations are primarily those of an upper respiratory tract infection in immunocompetent adults, increasing data suggest that this pathogen causes lower respiratory tract infection in this population (6,7). Data from early and recent studies in adult lung transplant recipients suggest that parainfluenza virus infection in these patients involves the lower respiratory tract between 10-66% of cases (10)(11)(12)(13)(14).…”

Section: Clinical Featuresmentioning

confidence: 99%

“…In adults these infections are usually mild and restricted to the upper respiratory tract (5). However, recent studies of the viral etiology of acute lower respiratory tract infections in adults indicate that parainfluenza virus accounts for 2.5 to 11.5% of hospitalized adult patients (6,7). In addition, these studies indicate that parainfluenza virus is an important pathogen in all age groups.…”

Section: Introductionmentioning

confidence: 99%

“…Parainfluenza type 4 is infrequently isolated and is therefore relatively uncharacterized. Studies in the adult immunocompetent population indicate an even distribution of parainfluenza virus serotypes all year long (6,7,16). However, among adult lung transplant patients, infections are described to be more prevalent during the spring and summer months and are caused mostly by parainfluenza virus type 3 (63-100%) (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Vilchez

Dauber

McCurry

et al. 2003

American Journal of Transplantation

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Parainfluenza virus is a common cause of seasonal upper respiratory tract infections in children and adults. Studies indicate that parainfluenza virus may play an important role in the etiology of respiratory tract infections in lung transplant recipients with an estimated incidence of 5.3 per 100 patients. Parainfluenza virus type 3 is the most frequent serotype in lung transplant patients. The rate of lower respiratory tract infections with parainfluenza virus among lung transplant recipients is between 10 and 66% of cases. In addition, trans-bronchial biopsy at the time of parainfluenza infection shows signs of acute allograft rejection. Subsequently, 32% of patients have been found to have active bronchiolitis obliterans at a median time of 6 months (range 1-14) postviral infection. These findings indicate that parainfluenza virus infections may have long-term implications for lung transplant recipients. Further studies are required to identify the mechanisms of immunomodulation of parainfluenza virus among these patients. In addition, controlled studies are needed to evaluate the efficacy of aerosolized ribavarin in the treatment of parainfluenza virus infection and to determine whether vaccines may be effective in these high-risk patients.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Vilchez

Dauber

McCurry

et al. 2003

American Journal of Transplantation

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“…4,7,10 In Brazil, data from the Sistema de Informações sobre Mortalidade (Mortality Information System) indicates the growing importance of hospital admissions and deaths due to respiratory diseases among the elderly, even considering the ageing of the population. 6 In 1995, in São Paulo State, the proportional rate of mortality due to pneumonia among persons older than 70 years was 9%, with a specific mortality of 594.03 per 100,000 population.…”

Section: Introductionmentioning

confidence: 99%

Impacto da vacinação contra influenza na mortalidade por doenças respiratórias em idosos

2005

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ObjectiveRespiratory diseases, especially infectious ones, are becoming increasingly representative in the morbidity and mortality patterns of elderly persons. The aim of the present study was to analyze trends in the mortality by respiratory diseases and to observe the impact of influenza vaccination on mortality rates. MethodsThe study was carried out between 1980 and 2000. Subjects were elderly persons living in the State of São Paulo, and mortality data were obtained from the Mortality Information System of the Brazilian Ministry of Health. This is an ecological timeseries study. We analyzed the time trends of standardized mortality rates by infectious diseases, according to age group (60-64, 65-69, 70-74, 75-79, and 80+ years) and sex, using polynomial regression. We estimated confidence intervals for the mean expected response in the years following the intervention. ResultsRates increased for both sexes among the elderly population. After the intervention, we observed a declining trend with respect to mortality indicators. For older males, the mean rate in the 1980-1998 period was 5.08 deaths per thousand men, with a linear, non-constant increase of 0.13 per year; in 2000, the rate observed was 4.72 deaths per thousand men. The mean annual rate among women over 60 years was 3.18 deaths per thousand women, with a non-constant increase of 0.08 per year; in 2000, the rate observed was 2.99 deaths per thousand women. There was also a significant reduction in mortality rates in all age groups. Conclusions Data indicate the importance of respiratory diseases among the elderly population and suggest that specific protection against influenza has a positive effect on the prevention of mortality due to these diseases.

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“…20 Anatomically, preterm infants have smaller and histologically immature airways, increasing vulnerability to respiratory pathogens. [21][22][23] Treatment of bronchopulmonary dysplasia, a common neonatal morbidity, may include steroids that further depress the antibody titer response to pertussis infection. 24 Strategies for reduction of pertussis in neonates Based on this information, the 2006 immunization schedule includes administration of a single booster dose of tetanus and acellular pertussis (Tdap) universally for adolescents 11 and 12 years of age.…”

Section: Neonates Most Vulnerable To Pertussis Infectionmentioning

confidence: 99%

Rationale for the administration of acellular pertussis vaccine to parents of infants in the neonatal intensive care unit

et al. 2006

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Impact of Respiratory Virus Infections on Persons With Chronic Underlying Conditions

Cited by 496 publications

References 37 publications

Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Impacto da vacinação contra influenza na mortalidade por doenças respiratórias em idosos

Rationale for the administration of acellular pertussis vaccine to parents of infants in the neonatal intensive care unit

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