Impact of repetitive theta burst stimulation on motor cortex excitability

Gamboa, Olga Lucía; Antal, Andrea; Laczó, Bence; Moliadze, Vera; Nitsche, Michael A.; Paulus, Walter

doi:10.1016/j.brs.2010.09.008

Cited by 93 publications

(104 citation statements)

References 29 publications

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“…2010) or when applying two conventional blocks at different intervals (Gamboa et al . 2001). The number of stimuli within one train and the pattern of stimulation with breaks of different length appear to be important parameters in addition to the current cortical state.…”

Section: Discussionmentioning

confidence: 99%

Multiple blocks of intermittent and continuous theta‐burst stimulation applied via transcranial magnetic stimulation differently affect sensory responses in rat barrel cortex

Thimm

Funke

2015

The Journal of Physiology

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Cortical sensory processing varies with cortical state and the balance of inhibition to excitation. Repetitive transcranial magnetic stimulation (rTMS) has been shown to modulate human cortical excitability. In a rat model, we recently showed that intermittent theta-burst stimulation (iTBS) applied to the corpus callosum, to activate primarily supragranular cortical pyramidal cells but fewer subcortical neurons, strongly reduced the cortical expression of parvalbumin (PV), indicating reduced activity of fast-spiking interneurons. Here, we used the well-studied rodent barrel cortex system to test how iTBS and continuous TBS (cTBS) modulate sensory responses evoked by either single or double stimuli applied to the principal (PW) and/or adjacent whisker (AW) in urethane-anaesthetized rats. Compared to sham stimulation, iTBS but not cTBS particularly enhanced late (>18 ms) response components of multi-unit spiking and local field potential responses in layer 4 but not the very early response (<18 ms). Similarly, only iTBS diminished the suppression of the second response evoked by paired PW or AW–PW stimulation at 20 ms intervals. The effects increased with each of the five iTBS blocks applied. With cTBS a mild effect similar to that of iTBS was first evident after 4–5 stimulation blocks. Enhanced cortical c-Fos and zif268 expression but reduced PV and GAD67 expression was found only after iTBS, indicating increased cortical activity due to lowered inhibition. We conclude that iTBS but less cTBS may primarily weaken a late recurrent-type cortical inhibition mediated via a subset of PV+ interneurons, enabling stronger late response components believed to contribute to the perception of sensory events.

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Section: Discussionmentioning

confidence: 99%

Multiple blocks of intermittent and continuous theta‐burst stimulation applied via transcranial magnetic stimulation differently affect sensory responses in rat barrel cortex

Thimm

Funke

2015

The Journal of Physiology

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“…This approach was further motivated by a report of extended plastic changes after repeated application of the TBS protocol over the frontal eye fi eld (Nyffeler et al 2006) and by preliminary results of increasing antidepressant effects of cTBS with an increasing number of applied stimuli (Chistyakov et al 2010). In contrast, more recent studies have found that a prolongation of cTBS and iTBS over the motor cortex can diminish or even reverse neuroplastic after-effects (Gamboa et al 2010(Gamboa et al , 2011. Based on these fi ndings the choice of TBS parameters in our study may have been suboptimal.…”

Section: Statement Of Interestmentioning

confidence: 95%

Bilateral prefrontal rTMS and theta burst TMS as an add-on treatment for depression: A randomized placebo controlled trial

Prasser

Schecklmann

Poeppl

et al. 2014

The World Journal of Biological Psychiatry

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“…For iTBS, the basic TBS pattern was given in a 2-s train and repeated every 10 s for 20 cycles (190 s, total of 600 pulses). In the cTBS paradigm, the TBS pattern was given in a continuous train lasting 40 s (i.e., 600 bursts) [7,17]. The intensity was set to 80 % RMT.…”

Section: Direct Theta Burst Cortical Stimulation and Experimental Designmentioning

confidence: 99%

Novel Use of Theta Burst Cortical Electrical Stimulation for Modulating Motor Plasticity in Rats

et al. 2015

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Various forms of cortical stimulation are capable of modulating motor cortical excitability through plasticity-like mechanisms and thus might have therapeutic potential for neurological diseases. To better understand the neural mechanism underlying the cortical neuromodulation effects and to enable translational research in rodent disease models, we developed a focused brain stimulation method using cortical electrical stimulation (CES) on the motor cortex in anesthetized rats. A specific stimulation scheme using theta burst stimulation (TBS) was then adopted to observe the facilitatory and inhibitory effects in motor cortical excitability. Adult male SpragueDawley rats were used for all experiments. Under urethane anesthesia, two epidural stainless steel screw electrodes were unilaterally implanted over the primary motor cortex targeting the forelimb area. Brachioradialis motor evoked potentials (MEPs) were obtained by single-pulse CES. Acute MEP changes were measured before and after intermittent and continuous TBS (iTBS and cTBS). For sham intervention, electrodes were implanted, but no TBS was delivered. To examine TBS-elicited plasticity responses, MEP amplitude was measured at baseline and for 30 min after iTBS or cTBS. The MEPs were significantly enhanced immediately after iTBS (p = 0.001) and remained enhanced for 30 min (p \ 0.001) compared to the baseline MEP. Similarly, the MEPs were suppressed in 5 min (p = 0.035) and lasted for 30 min or more (p \ 0.001) after cTBS. No effect was noted on the MEP magnitude in rats under sham stimulation (p [ 0.05). The developed TBS scheme uses the focused CES method to produce consistent, rapid, and controllable electrophysiological changes in the motor cortex. In particular, the cortical plasticity can be modulated in rat models via the CES-TBS protocols. These findings may have translational relevance for establishing new therapeutic CES applications in neurological disorders.

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Impact of repetitive theta burst stimulation on motor cortex excitability

Cited by 93 publications

References 29 publications

Multiple blocks of intermittent and continuous theta‐burst stimulation applied via transcranial magnetic stimulation differently affect sensory responses in rat barrel cortex

Multiple blocks of intermittent and continuous theta‐burst stimulation applied via transcranial magnetic stimulation differently affect sensory responses in rat barrel cortex

Bilateral prefrontal rTMS and theta burst TMS as an add-on treatment for depression: A randomized placebo controlled trial

Novel Use of Theta Burst Cortical Electrical Stimulation for Modulating Motor Plasticity in Rats

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