Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension

Tiago, Armindo; Badenhorst, Danelle; Nkeh, Benedicta; Candy, Geoffrey P.; Brooksbank, Richard; Sareli, Pinhas; Libhaber, Elena; Samani, Nilesh J.; Woodiwiss, Angela J.; Norton, Gavin R.

doi:10.1016/j.amjhyper.2003.07.010

Cited by 29 publications

(24 citation statements)

References 32 publications

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“…1 The mechanisms to explain the weaker correlations of cardiovascular indices and obesity in the African population remain unclear. But during the past few years genetic differences have been found regarding hypertension 23 and diabetes susceptibility, 24 as well as lipid levels 25 between the South African black population and the Caucasians who are from European descent. Because the present study aimed to exclude environmental influences when investigating this relationship, it is speculated that genetic differences regarding cardiovascular function in Africans (which have perhaps not been discovered yet) might be accountable for the effects observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Should obesity be blamed for the high prevalence rates of hypertension in black South African women?

et al. 2008

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Hypertension is highly prevalent in South Africa, resulting in high stroke mortality rates. Since obesity is very common among South African women, it is likely that obesity contributes to the hypertension prevalence. The aims were to determine whether black African women have higher blood pressures (BPs) than Caucasian women, and whether obesity is related to their cardiovascular risk. African (N ¼ 102) and Caucasian (N ¼ 115) women, matched for age and body mass index, were included. Correlations between obesity (total body fat, abdominal obesity and peripheral fat) and cardiovascular risk markers (haemodynamic parameters, lipids, inflammatory markers, prothrombotic factors, adipokines, HOMA-IR (homoeostasis model assessment insulin resistance)) were compared between the ethnic groups (adjusted for age, smoking, alcohol and physical activity). Comparisons between low-and high-BP groups were also made for each ethnic group. Results showed that African women had higher BP (Po0.01) with increased peripheral vascular resistance. Surprisingly, African women showed significantly weaker correlations between obesity measures and cardiovascular risk markers when compared to Caucasian women (specifically systolic BP, arterial resistance, cardiac output, fibrinogen, plasminogen activator inhibitor-1, leptin and resistin). Interestingly, the latter risk markers were also not significantly different between low-and high-BP African groups. African women, however, presented significant correlations of obesity with triglycerides, C-reactive protein and HOMA that were comparable to the Caucasian women. Although urban African women have higher BP than Caucasians, their obesity levels are weakly related to traditional cardiovascular risk factors compared to Caucasian women. The results, however, suggest a link with the development of insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Should obesity be blamed for the high prevalence rates of hypertension in black South African women?

et al. 2008

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“…Polymorphism of the aldosterone synthase gene, CYP11B2, is linked to a higher initial systolic BP in previously untreated black South Africans. 45 More of such studies are under way and may uncover other genetic changes in the enzymes controlling the RAAS system.…”

Section: Genes Controlling the Renin-angiotensinaldosterone Systemmentioning

confidence: 99%

Hypertension in Sub-Saharan African Populations

2005

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Background-Hypertension in sub-Saharan Africa is a widespread problem of immense economic importance because of its high prevalence in urban areas, its frequent underdiagnosis, and the severity of its complications. Methods and Results-We searched PubMed and relevant journals for words in the title of this article. Among the major problems in making headway toward better detection and treatment are the limited resources of many African countries. Relatively recent environmental changes seem to be adverse. Mass migration from rural to periurban and urban areas probably accounts, at least in part, for the high incidence of hypertension in urban black Africans. In the remaining semirural areas, inroads in lifestyle changes associated with "civilization" may explain the apparently rising prevalence of hypertension. Overall, significant segments of the African population are still afflicted by severe poverty, famine, and civil strife, making the overall prevalence of hypertension difficult to determine. Black South Africans have a stroke rate twice as high as that of whites. Two lifestyle changes that are feasible and should help to stem the epidemic of hypertension in Africa are a decreased salt intake and decreased obesity, especially in women. Conclusions

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“…Nevertheless, we did not find any evidence of association between AGT 235M/T polymorphism and the incidence of hypertension in our study population. Similarly, Rotimi et al [6] and Tiago et al [23] found no association between AGT 235M/T polymorphism and the hypertension in their study. But compared to the previous work, we obtained a higher frequency of the TT genotype in this study.…”

Section: Discussionmentioning

confidence: 95%

“…Among the approaches used for searching for hypertension loci, few are linkage studies and most often are association studies [19]. The use of candidate gene approach includes the reninangiotensin system genes but given the ethnic diversity and the selection bias, the results from these studies are often faced with interpretation difficulties [20][21][22][23]. The uniqueness of this study lies in the fact that it is the first of its kind in the Burkinabe population that combines the RAS genes polymorphisms and the hypertension.…”

Section: Discussionmentioning

confidence: 99%

Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

Kologo¹,

Tchelougou²,

Karou³

et al. 2017

Archives of Cardiovascular Diseases Supplements

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Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10 −4 ). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.

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Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension

Abstract: A variant within the CYP11B2 locus has a clinically important impact on the severity of SBP changes in individuals with newly diagnosed hypertension who are of African ethnicity.

Cited by 29 publications

References 32 publications

Should obesity be blamed for the high prevalence rates of hypertension in black South African women?

Should obesity be blamed for the high prevalence rates of hypertension in black South African women?

Hypertension in Sub-Saharan African Populations

Renin-angiotensin system genes polymorphisms and essential hypertension in Burkina Faso, West Africa

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