Impact of recombinant follicle-stimulating hormone and human menopausal gonadotropins on in vitro fertilization outcome

Strehler, E.; Abt, Markus; El-Danasouri, Imam; Santo, M. De; Sterzik, K.

doi:10.1016/s0015-0282(00)01696-4

Cited by 65 publications

(34 citation statements)

References 12 publications

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“…However, in agreement with our results, recent studies of urinary FSH or hMG and recombinant FSH had similar results in terms of oocyte and embryo quality and of implantation and pregnancy rates (25,26,34).…”

Section: Fertility and Sterilitysupporting

confidence: 93%

“…These discrepant findings require further investigation. In a recent study, hMG (1:1 FSH/LH) produced comparable results to recombinant FSH when used alone for ovarian stimulation (25,26,56).…”

Section: T a B L Ementioning

confidence: 94%

“…Recent data show that hMG compares favorably to recombinant FSH (25,26) in terms of oocyte and embryo quality and subsequent pregnancy rates.…”

mentioning

confidence: 99%

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Effect of highly purified urinary follicle-stimulating hormone on oocyte and embryo quality

Selman¹,

Santo²,

Sterzik³

et al. 2002

Fertility and Sterility

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Objective:To determine the effects of ovarian stimulation with highly purified urofollitropin on oocyte and embryo quality. Main Outcome Measure(s):Primary end points were number of morphologically mature oocytes retrieved, embryo quality, and pregnancy and implantation rates. Secondary end points were: total number of days of FSH stimulation, total dose of gonadotropin administered, fertilization rate per number of retrieved oocytes, embryo cleavage rate, live birth and miscarriage rates, endometrial thickness and estradiol level on the day of hCG administration, cancellation rate, and incidence of moderate or severe ovarian hyperstimulation syndrome. Result(s): Pregnancy and implantation rates were nonsignificantly higher in the urinary FSH group than the recombinant FSH group (46.5% vs. 36.8% and 22.1% vs. 15.8%, respectively). The grade 1 embryo score was significantly higher in the urinary FSH group than the recombinant FSH (42.1% vs. 33.5%), and the live birth rate was nonsignificantly higher in the former group. Conclusion(s):Highly purified urinary FSH is as effective, efficient, and safe for clinical use as recombinant FSH. (Fertil Steril 2002;78:1061-7.

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Section: Fertility and Sterilitysupporting

confidence: 93%

Section: T a B L Ementioning

confidence: 94%

See 1 more Smart Citation

Effect of highly purified urinary follicle-stimulating hormone on oocyte and embryo quality

Selman¹,

Santo²,

Sterzik³

et al. 2002

Fertility and Sterility

Self Cite

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show abstract

“…However, recent reports demonstrate that urinary FSH is considerably better than recombinant FSH in terms of oocyte and embryo quality and pregnancy and implantation rates, although the number of retrieved oocytes is higher in favour of rFSH [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the efficacy of rFSH compared to uFSH in terms of oocyte and embryo quality has been evaluated, and the results reported are highly in favour of urinary FSH. Some authors have attributed the difference to the presence of LH activity in the urinary FSH preparation which has a positive effect on oocyte maturation and embryo quality [13][14][15], while others assume that the difference between rFSH and uFSH may reside in the nature of FSH isoform activities [15,16].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a combined protocol of urinary and recombinant follicle-stimulating hormone used for ovarian stimulation of patients undergoing ICSI cycle

Pacchiarotti

Aragona

Gaglione³

et al. 2007

J Assist Reprod Genet

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Purpose To evaluate the efficacy of using both urinary and recombinant FSH in a combined protocol for ovarian stimulation in an IVF treatment program. Method A total of 119 infertile couples undergoing ICSI treatment were randomized prospectively in this study. After a standard down-regulation with GnRH analogue, the patients were randomized in 2 groups 58 received combined urinary and recombinant FSH, starting with uFSH and then rFSH, and 61 controls received only recombinant FSH. Result(s) Pregnancy and implantation rates were significantly higher in the combined uFSH/rFSH group than the control (rFSH) group (43.9% vs 22.1% and 27.5% vs 13.2% respectively). Metaphase II oocyte and grade 1 embryos were significantly higher in favour of combined uFSH/rFSH group than the recombinant FSH group. Conclusion(s) This study shows that using a combination of both urinary and recombinant FSH for ovarian stimulation improves oocyte maturity and embryo cleavage, and increases pregnancy and implantation rates.

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Human menopausal gonadotropin versus recombinant follicle stimulation hormone for ovarian stimulation in assisted reproductive cycles

Westergaard¹,

Bossuyt²,

Veen³

et al. 2003

Cochrane Database of Systematic Reviews

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For all three GnRHa protocols analysed there is insufficient evidence of a difference between hMG and rFSH on ongoing pregnancy or live birth. More large randomised trials are needed to estimate the difference between hMG and rFSH more precisely. Such trials should preferably (1) use a consistent long GnRHa protocol and (2) use a fixed dose of gonadotrophin such to prevent potentially subjective decisions of the clinician in dosing and (3) take live birth as primary endpoint. At this moment in time however, in prescribing gonadotrophins for ovarian hyperstimulation in IVF one should use the least expensive medication.

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Impact of recombinant follicle-stimulating hormone and human menopausal gonadotropins on in vitro fertilization outcome

Cited by 65 publications

References 12 publications

Effect of highly purified urinary follicle-stimulating hormone on oocyte and embryo quality

Effect of highly purified urinary follicle-stimulating hormone on oocyte and embryo quality

Efficacy of a combined protocol of urinary and recombinant follicle-stimulating hormone used for ovarian stimulation of patients undergoing ICSI cycle

Human menopausal gonadotropin versus recombinant follicle stimulation hormone for ovarian stimulation in assisted reproductive cycles

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