Impact of radiotherapy schedule on survival of patients treated with immune-checkpoint inhibitors for advanced melanoma and non-small cell lung cancer

Increased abscopal responses after radiation therapy for oligoprogressive patients receiving immune checkpoint inhibitors?

“…Many non-randomized report-initiated ICI and SABR concurrently with uncertainties regarding additional abscopal responses. Formenti et al, Saiag et al, and Sumodhee et al observed a 18%, 31.5% and 9.5% abscopal response rates, respectively, and a 10%, 0% and 9.5% stable disease rates, respectively (4,10,11).…”

“…According to Vanpouille-Box et al the amount of cytosolic DNA which reflects the immunogenicity of tumor cells, depends on the dose per fraction ( 17 ). Interestingly, most studies that reported abscopal response used dose per fraction less than 10 Gy: 9.5 Gy for Postow et al ( 3 ), 6–9.5 Gy for Formenti et al ( 4 ), 7–8 Gy for Chicas-Sett et al ( 6 ), 6 Gy for Saiag et al ( 10 ) and Sumodhee et al ( 11 ). Of note, in these studies abscopal response was not only observed after SABR but also after conventional 3-dimensional conformal radiotherapy.…”