Impact of radiotherapy on local control and survival in uterine sarcomas: a retrospective study from the GRUP ONCOLOGIC CATALÀ-OCCITÀ

Ferrer, Ferran; Sabater, S.; Farrús, Blanca; Guedea, Ferrán; Rovirosa, Á.; Anglada, Lluís; Delannes, M.; Marin, S.; Dubois, Jean‐Bernard; Daly-Schveitzer, N.

doi:10.1016/s0360-3016(98)00515-x

Cited by 63 publications

(38 citation statements)

References 24 publications

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“…the retroperitoneum, head and neck, breast and uterus, no clear-cut improvement in local control has been demonstrated with adjuvant radiotherapy (10, 18, 19, 27 Á/30). However, in several studies a trend towards an increased local control rate has been observed when radiotherapy is added (10,19,29,30). As for STS of the extremities, prediction of cure of these STS entities is related to tumour grade and the degree of resection.…”

Section: Prognostic and Predictive Factorsmentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

2003

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Section: Prognostic and Predictive Factorsmentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

2003

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“…The benefit of adjuvant radiotherapy to surgery has been demonstrated by several studies, with greater local control 85% versus 43% in five years, although the survival benefit remains uncertain [19][20][21]. Irradiation is either by delivering radiotherapy doses of 45-50 Gray, followed by vaginal brachytherapy 15 to 20 Gray; or by exclusive brachytherapy from 50 to 60 Gray [22].…”

Section: Discussionmentioning

confidence: 99%

Management of Uterine Sarcomas

Naim¹,

Bouchbika²,

Aksim³

et al. 2012

JCT

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Uterine sarcomas are rare malignant tumors characterized by a great clinical and histopathological diversity. The aim of this work is to analyze the difficulties of diagnosis, therapeutic and prognosis posed by these tumors. Thirty-seven patients with uterine sarcoma, collected in the service Radiotherapy and Oncology, University Ibn Rochd of Casablanca between January 2000 and December 2007 were included in this study retrospective. The average patient age was 50 years (17 -76). The bleeding was present in all patients, isolated in 54% of cases associated with pelvic pain in 24.6% and a mass abdomino-pelvic in seven patients. The average time of evolution was 10 months. The main histological type was found leiomyosarcoma. Twenty four patients in our series underwent total hysterectomy without annexial conservation. The surgery R0 was obtained in 43% of cases. The sarcomas were classified as stage IV in 51.4%. Adjuvant radiotherapy was indicated in 13 patients. After a mean of 20 months, half of patients evaluable presented a local relapse and/or metastatic, the third of cases were tumor progression while complete remission was maintained in 18.5% of cases. Uterine sarcomas are rare malignant mesenchymal tumor, which often occur in women after menopause. The main prognostic factors are hormonal status of the patient, stage clinical, histological type, histological grade and quality surgical excision. The management of uterine sarcomas is multidisciplinary, based mainly on surgery remains the only means of cure. Adjuvant radiotherapy allows decreased risk of local recurrence, with no impact on survival achieved at best 30% at 5 years. The role of chemotherapy remains confirm.

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“…Cependant, dans beaucoup de sé ries ré trospectives, la radiothé rapie ne semble pas avoir d'influence sur la survie globale, mais semble en revanche augmenter le contrô le local (Tableau 2). Les quelques é tudes ré trospectives qui mentionnent un effet sur la survie sont souvent critiquables sur le plan mé thodologique (patientes hé té rogè nes, centres multiples, absence de relecture des lames, nombreux sarcomes du stroma de bas grade, entre autres) [6,12].…”

Section: Radiothé Rapie Adjuvanteunclassified

Uterine sarcomas

Pautier

2007

Oncologie

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Impact of radiotherapy on local control and survival in uterine sarcomas: a retrospective study from the GRUP ONCOLOGIC CATALÀ-OCCITÀ

Cited by 63 publications

References 24 publications

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

Management of Uterine Sarcomas

Uterine sarcomas

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