Impact of radical systematic mediastinal lymphadenectomy on tumor staging in lung cancer

Izbicki, Jakob R.; Passlick, Bernward; Karg, O.; Bloechle, C.; Pantel, Klaus; Knoefel, Wolfram Trudo; Thetter, O.

doi:10.1016/0003-4975(94)00717-l

Cited by 115 publications

(62 citation statements)

References 16 publications

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“…In contrast, the number of patients with N2 lymph node involvement at multiple levels was signiWcantly increased in the LA group than that in the sampling group. Izbicki et al (1995) gave the similar results in a randomized controlled trial. Because the patients with N2 disease at multiple levels had a worse prognosis, LA seems to be essential for identifying these subgroup patients at risk by resecting a suYcient number of lymph nodes.…”

Section: Discussionsupporting

confidence: 85%

Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer

Dong

et al. 2008

J Cancer Res Clin Oncol

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Section: Discussionsupporting

confidence: 85%

Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer

Dong

et al. 2008

J Cancer Res Clin Oncol

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“…MLND is reported to be more accurate in determining multilevel N2 disease and skip metastases. [10][11][12][13][14] Because two to fi ve lymph nodes were resected from each N2 station in the majority of patients in our study, it is likely that occult N2 disease would be discovered if present and, despite rigorous systematic sampling prior to randomization, 21 patients were found to have occult N2 disease with MLND.…”

Section: Discussionmentioning

confidence: 99%

Number of Lymph Nodes Harvested From a Mediastinal Lymphadenectomy

Darling

Allen

Decker

et al. 2011

Chest

101

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The American College of Surgeons Oncology Group (ACOSOG) Z0030 study is a randomized, multiinstitutional, prospective trial designed to determine whether long-term survival is affected by mediastinal lymph node dissection (MLND) vs lymph node sampling (MLNS) at the time of pulmonary resection for lung cancer. We enrolled 1,023 eligible and /or evaluable patients with stage T1 or T2, N0 or nonhilar N1 lung cancer to either MLNS (n 5 498) or complete mediastinal lymphadenectomy (n 5 525). After analysis, we concluded that a complete mediastinal lymphadenectomy adds little morbidity to a pulmonary resection for lung cancer and found that the overall operative mortality for pulmonary resection was 1.4% (14/1,023). 1 The impact of MLND on long-term survival will be determined once long-term follow-up data of the study are mature.Because lymph node status is a main determinate of stage, and thus prognosis, complete lymph node dissection has been recommended for all patients undergoing surgical resection of lung cancer. However, what constitutes a complete lymph node dissection is not defi ned, and different terminology is used to describe various techniques of surgical lymph node assessment.

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“…For the removal of mediastinal lymph nodes, many investigators insist on the importance of systematic nodal dissection (SND) for accurate staging (4)(5)(6)(7)(8)(9)(10).…”

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

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:Objective : Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. Methods : One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58 : sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. Results : The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 7.0 (p 0.001). Postoperatively N2 disease was detected in 8 patients (13.8% %) in the dissection group and 7 (11.5% %) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% % in the dissection group and 76.2% % in the sampling group (p = 0.60). Conclusions : Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer. J. Med. Invest. 55 : 37-43, February, 2008

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Impact of radical systematic mediastinal lymphadenectomy on tumor staging in lung cancer

Cited by 115 publications

References 16 publications

Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer

Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer

Number of Lymph Nodes Harvested From a Mediastinal Lymphadenectomy

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

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