Impact of Radiation on Male Fertility

Srivasatav, Srijan; Mishra, Jyoti; Keshari, Priyanka; Verma, Shailza; Aditi, Raina

doi:10.1007/978-3-031-12966-7_5

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…RF-EMR has been studied extensively for its effects on male fertility, but ndings are discrepant [4,5]. In a recent systematic review, the impact of mobile phone radiation on the quality of sperm was investigated, encompassing a total of 39 studies.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Melatonin ameliorates RF-EMR-induced oxidative damage in mouse testis by inhibiting ferroptosis through Nrf2 pathway activation

Wang,

Dong,

et al. 2023

Preprint

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Background In recent years, there has been increased examination of the harmful impacts of radiofrequency electromagnetic radiation (RF-EMR) on male reproductive ability, making it critical to explore effective protective measures. Melatonin has antioxidant and anti-apoptotic effects, and there is growing evidence that melatonin is beneficial to the reproductive process. The understanding of melatonin's biochemical mechanisms in safeguarding against testicular damage from RF-EMR exposure is limited. Results During the present investigation, it was observed that prolonged (8 weeks) exposure to RF-EMR [2.0 GHz; power density, 2.5 W/m2; systemic specific absorption rate (SAR), 0.125-0.5 W/kg] may lead to decreased testosterone and melatonin concentrations in the serum, reduced sperm quality, increased apoptosis levels, and elevated oxidative stress in male mice. Notably, the administration of melatonin (at a dosage of 10 mg/kg via intraperitoneal injection) mitigated the oxidative harm to the testicles and ferroptosis caused by RF-EMR in mice. Mechanistically, melatonin may inhibit ROS production and ferroptosis by stimulating the Nrf2 signaling pathway through its receptors (MT1/MT2). Conclusion Taken together, these results indicate that melatonin could potentially improve oxidative harm caused by RF-EMR in the testes of mice by blocking ferroptosis through the activation of the Nrf2 pathway via MT1/MT2 receptors.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Melatonin ameliorates RF-EMR-induced oxidative damage in mouse testis by inhibiting ferroptosis through Nrf2 pathway activation

Wang,

Dong,

et al. 2023

Preprint

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L-carnitine combined with traditional Chinese medicine for male infertility: A systematic review and meta-analysis

Yang,

Xue,

Zhou

et al. 2024

Heliyon

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Practice and development of male contraception: European Academy of Andrology and American Society of Andrology guidelines

Wang,

Meriggiola,

Amory

et al. 2023

Andrology

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BackgroundsDespite a wide spectrum of contraceptive methods for women, the unintended pregnancy rate remains high (45% in the US), with 50% resulting in abortion. Currently, 20% of global contraceptive use is male‐directed, with a wide variation among countries due to limited availability and lack of efficacy. Worldwide studies indicate that >50% of men would opt to use a reversible method, and 90% of women would rely on their partner to use a contraceptive. Additional reasons for novel male contraceptive methods to be available include the increased life expectancy, sharing the reproductive risks among partners, social issues, the lack of pharma industry involvement and the lack of opinion makers advocating for male contraception.AimThe present guidelines aim to review the status regarding male contraception, the current state of the art to support the clinical practice, recommend minimal requirements for new male contraceptive development and provide and grade updated, evidence‐based recommendations from the European Society of Andrology (EAA) and the American Society of Andrology (ASA).MethodsAn expert panel of academicians appointed by the EAA and the ASA generated a consensus guideline according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system.ResultsSixty evidence‐based and graded recommendations were produced on couple‐centered communication, behaviors, barrier methods, semen analysis and contraceptive efficacy, physical agents, surgical methods, actions before initiating male contraception, hormonal methods, non‐hormonal methods, vaccines, and social and ethical considerations.ConclusionAs gender roles transform and gender equity is established in relationships, the male contribution to family planning must be facilitated. Efficient and safe male‐directed methods must be evaluated and introduced into clinical practice, preferably reversible, either hormonal or non‐hormonal. From a future perspective, identifying new hormonal combinations, suitable testicular targets, and emerging vas occlusion methods will produce novel molecules and products for male contraception.

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Impact of Radiation on Male Fertility

Cited by 4 publications

References 44 publications

WITHDRAWN: Melatonin ameliorates RF-EMR-induced oxidative damage in mouse testis by inhibiting ferroptosis through Nrf2 pathway activation

WITHDRAWN: Melatonin ameliorates RF-EMR-induced oxidative damage in mouse testis by inhibiting ferroptosis through Nrf2 pathway activation

L-carnitine combined with traditional Chinese medicine for male infertility: A systematic review and meta-analysis

Practice and development of male contraception: European Academy of Andrology and American Society of Andrology guidelines

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