Impact of Quercetin on Pathomorphological Characteristics of Mandibular Bone in Rats Following Its Fracture Under Chronic Alcohol Intoxication

Abstract

This study aims at investigating the impact of water-soluble form of quercetin on the pathomorphological characteristics of the mandibular bone in rats following its incomplete fracture under chronic alcohol intoxication was investigated. Fourteen white male Wistar rats weighing 190-240 g were randomly divided into two groups: Group 1 comprised rats with incomplete mandibular fractures under chronic alcohol intoxication; animals in Group 2 received daily intraperitoneal injections of water-soluble quercetin (corvitin) in a dose of 10 mg/kg of quercetin for 14 days following the injury induction. It has been shown that chronic alcohol intoxication hinders reparative regeneration of bone tissue after an incomplete mandibular fracture, and is accompanied by a decrease in the relative amount of reticulofibrous bone tissue and fibroblastic cellular elements at the injury site, especially mature fibroblasts, as well as by delayed maturation of granulation tissue. Under experimental conditions, quercetin administration significantly contributed to normalizing the regenerative process by the 14th day of the posttraumatic period. This normalization was evidenced by increased relative amounts of reticulofibrous bone tissue, prevalence of fibroblastic cells in granulation tissue, and accelerated formation of the regenerate blood microcirculatory channel.