Impact of Quercetin Consumption on Phase-I and Phase-II Drug-Metabolizing Enzymes in Mice.

Gandhi, Rajinder Kaur; Khanduja, Krishan Lal

doi:10.3164/jcbn.14.107

Cited by 14 publications

(3 citation statements)

References 19 publications

(12 reference statements)

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“…Quercetin (1 ± 9 mg=ml), given for 8 weeks to Swiss NMRI mice in drinking water, increases hepatic and pulmonary GST (30 ±40 % respectively). GSH levels double following treatment with the highest dose of quercetin (Gandhi & Khanduja, 1993). Flavone,¯avanone and tangeretin in the diet similarly increase hepatic GST activity in rats (Siess et al 1996).…”

Section: Anticancer Mechanismsmentioning

confidence: 99%

Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants

Duthie¹,

Duthie²,

Kyle³

2000

Nutr. Res. Rev.

678

404

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Certain dietary antioxidants such as vitamin E and vitamin C are important for maintaining optimum health. There is now much interest in polyphenolic products of the plant phenylpropanoid pathway as they have considerable antioxidant activity in vitro and are ubiquitous in our diet. Rich sources include tea, wine, fruits and vegetables although levels are affected by species, light, degree of ripeness, processing and storage. This confounds the formulation of databases for the estimation of dietary intakes. Most attention to date has focused on the¯avonoids, a generic term which includes chalcones,¯avones,¯avanones,¯avanols and anthocyanins. There is little convincing epidemiological evidence that intakes of polyphenols are inversely related to the incidence of cancer whereas a number of studies suggest that high intakes of¯avonoids may be protective against CHD. In contrast, numerous cell culture and animal models indicate potent anticarcinogenic activity by certain polyphenols mediated through a range of mechanisms including antioxidant activity,

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Section: Anticancer Mechanismsmentioning

confidence: 99%

Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants

Duthie¹,

Duthie²,

Kyle³

2000

Nutr. Res. Rev.

678

404

View full text Add to dashboard Cite

show abstract

“…It is known that the flavonolquercetin is an inducer of phase II enzymes and detoxification of carcinogens. 28,29 Prestera et al 30 proposed that anti-carcinogenic diet can inhibit cancer initiation acting on the balance between activation of phase I enzymes (such as cytochrome P450) and phase II (detoxification enzymes such as GST, QR1 and UDP-glucuronyltransferase). Factors that suppress or inhibit phase I enzymes or induce phase II enzymes are likely to have a protective role against cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Investigation on the Chemopreventive Profile of Garcinia Xanthochymus

Giabardo¹,

Agustoni²,

Daniara³

et al. 2015

Int. Res. J. Pharm.

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Garcinia species have been reported to possess compounds with antibacterial, antioxidant, apoptotic, hepatoprotective and others biological effects. The Garcinia xanthochymus Hook. f. (Clusiaceae) is a native plant from some Asian countries and is the most cultivated species in Brazil. Also, has been described to possess some in vitro anti carcinogenic compounds. Because of these characteristics, in the present study it was assessed the ability of extracts, fractions and a biflavonoidmorelloflavone, obtained by bio guided assay from G. xanthochymus, in their chemo-preventive role by quinona reductase 1 (QR1) induction and genotoxic/antigenotóxic damage. To evaluate the chemo-preventive profile of compounds extracted from G. xanthochymus, the quinone reductase assay and Comet assay were performed. It was observed a doubling of the quinone reductase enzyme activity by ethyl acetate and butanolic fractions, and morelloflavone (p < 0.001). However, by the Comet assay was observed the genotoxicity of morellofavone, ethyl acetate and butanolic fractions. Regarding anti-genotoxicity, the same fractions and morelloflavone caused DNA damage in post-treatment. Our results suggest that although there is induction of quinone reductase enzyme from morelloflavone, ethyl acetate and butanolic fractions isolated from G. xanthochymus, these have genotoxic profile in some concentrations, showing that the widespread use of the plant could bring harm. Additional tests are needed to evaluate the toxicity power of the G. xanthochymus.

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“…The impact of quercetin on the regulation of CYP1A1 and CYP1B2 was also demonstrated. In another study, the hepatic activity of the detoxifying enzymes glutathione peroxidase and glutathione S-transferase increased in rats administered quercetin contained in water, with the latter enzyme elevated significantly [159]. Quercetin has also been shown to increase the activity of NAD(P)H: quinone reductase in MCF-7 human breast cancer cells, which could be a way to protect against carcinogens [160].…”

Section: Effects Of Quercetin On Carcinogen Metabolismmentioning

confidence: 96%

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

Cecerska-Heryć,

Wiśniewska,

Serwin

et al. 2024

IJMS

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Malignant tumors are the second most common cause of death worldwide. More attention is being paid to the link between the body’s impaired oxidoreductive balance and cancer incidence. Much attention is being paid to polyphenols derived from plants, as one of their properties is an antioxidant character: the ability to eliminate reactive oxygen and nitrogen species, chelate specific metal ions, modulate signaling pathways affecting inflammation, and raise the level and activity of antioxidant enzymes while lowering those with oxidative effects. The following three compounds, resveratrol, quercetin, and curcumin, are polyphenols modulating multiple molecular targets, or increasing pro-apoptotic protein expression levels and decreasing anti-apoptotic protein expression levels. Experiments conducted in vitro and in vivo on animals and humans suggest using them as chemopreventive agents based on antioxidant properties. The advantage of these natural polyphenols is low toxicity and weak adverse effects at higher doses. However, the compounds discussed are characterized by low bioavailability and solubility, which may make achieving the blood concentrations needed for the desired effect challenging. The solution may lie in derivatives of naturally occurring polyphenols subjected to structural modifications that enhance their beneficial effects or work on implementing new ways of delivering antioxidants that improve their solubility and bioavailability.

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Impact of Quercetin Consumption on Phase-I and Phase-II Drug-Metabolizing Enzymes in Mice.

Cited by 14 publications

References 19 publications

Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants

Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants

Preliminary Investigation on the Chemopreventive Profile of Garcinia Xanthochymus

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

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