Impact of purple sweet potato (Ipomoea batatas L.) polysaccharides on the fecal metabolome in a murine colitis model

Abstract

Purple sweet potato polysaccharides (PSPP) play an important role in regulating the gut microbiota, modulating intestinal immunity and ameliorating colonic inflammation.

Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism

“…Comparable results were reported in previous research involving purple sweet potato polysaccharides, where PSWP-I with a lower molecular weight (103 kDa) showed a superior regulation effect on key biomarkers in metabolic pathways than PSAP-I with a higher molecular weight (180 kDa). 41…”

“…Steroid hormone biosynthesis could be disrupted in DSS-induced colitis mice and could be regulated by purple sweet potato polysaccharide. 41 In another study, polysaccharides from Dendrobium huoshanense had the ability to alleviate UC by regulating metabolic pathways, such as steroid hormone biosynthesis. 42 Furthermore, dihydrocortisol, 3a,7b,12a-trihydroxy-5a-cholanoic acid, dehydroepiandrosterone, cortisol, aldosterone, and cortisone, related to steroid hormone biosynthesis, were increased 0.83-, 1.32-, 1.13-, 0.55-, 1.10-, and 0.81-fold, respect-ively, compared to those in the Model group.…”

“…Comparable results were reported in previous research involving purple sweet potato polysaccharides, where PSWP-I with a lower molecular weight (103 kDa) showed a superior regulation effect on key biomarkers in metabolic pathways than PSAP-I with a higher molecular weight (180 kDa). 41 3.8. ABPs, ABP-1, and ABP-2 showed no significant toxicity Safety is a crucial factor in the application of polysaccharides obtained from A. bisporus.…”

Microbiome–Metabolomics Analysis Reveals the Mechanism of Holothuria leucospilota Polysaccharides (HLP) in Ulcerative Colitis

“…[ 31 ] Purple sweet potato polysaccharides (PSPP)s’ intake significantly reduced the content of free unsaturated fatty acids (e.g., oleic acid) in colitis mice and improved the biosynthetic metabolic pathway of cutin, suberine, and wax biosynthesis. [ 32 ]…”

“…[31] Purple sweet potato polysaccharides (PSPP)s' intake significantly reduced the content of free unsaturated fatty acids (e.g., oleic acid) in colitis mice and improved the biosynthetic metabolic pathway of cutin, suberine, and wax biosynthesis. [32] Amino acids are used by the intestinal microbiota for their protein synthesis and catabolic pathways. This study showed that the ameliorative effect of HLP on DSS-induced rats was mainly reflected in the regulation of amino acid metabolism.…”