Impact of Pubertal Stage at First Drink on Adult Drinking Behavior

Blomeyer, Dorothea; Friemel, Chris Maria; Buchmann, Arlette F.; Banaschewski, Tobias; Laucht, Manfred; Schneider, Miriam

doi:10.1111/acer.12154

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…More than half of the studies outlined in Table 1 demonstrate that adolescent ethanol exposure results in persistent increases in ethanol intake in adulthood, findings across multiple models of exposure and intake assessment methods. For example, although Blomeyer et al (2013) exposed male, Wistar rats via a 2BC paradigm during mid-adolescence, and Pandey et al (2015) administered ethanol IP (2 g/kg) in male, Sprague-Dawley rats, both studies demonstrated higher intakes in ethanol-exposed animals relative to their age-matched controls. Similarly, Gass et al (2014) reported increased ethanol intake in adulthood following adolescent VI exposure.…”

Section: Adolescent Ethanol Exposure: Impact On Ethanol Intake In Adumentioning

confidence: 99%

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Towner

2020

Front. Behav. Neurosci.

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Adolescence is a developmental period associated with rapid age-specific physiological, neural, and hormonal changes. Behaviorally, human adolescents are characterized by age-typical increases in novelty-seeking and risk-taking, including the frequent initiation of alcohol and drug use. Alcohol use typically begins during early adolescence, and older adolescents often report high levels of alcohol consumption, commonly referred to as high-intensity drinking. Early-onset and heavy drinking during adolescence are associated with an increased risk of developing alcohol use disorders later in life. Yet, long-term behavioral consequences of adolescent alcohol use that might contribute to excessive drinking in adulthood are still not well understood. Recent animal research, however, using different exposure regimens and routes of ethanol administration, has made substantial progress in identifying the consequences of adolescent ethanol exposure that last into adulthood. Alterations associated with adolescent ethanol exposure include increases in anxiety-like behavior, impulsivity, risk-taking, and ethanol intake, although the observed alterations differ as a function of exposure regimens and routes of ethanol administration. Rodent studies have also shown that adolescent ethanol exposure produces alterations in sensitivity to ethanol, with these alterations reminiscent of adolescent-typical ethanol responsiveness. The goal of this mini-review article is to summarize the current state of animal research, focusing on the long-term consequences related to adolescent ethanol exposure, with a special emphasis on the behavioral alterations and changes to ethanol sensitivity that can foster high levels of drinking in adulthood.

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Section: Adolescent Ethanol Exposure: Impact On Ethanol Intake In Adumentioning

confidence: 99%

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Towner

2020

Front. Behav. Neurosci.

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“…Importantly, an increasing number of studies have revealed that the adolescent brain is particularly vulnerable to alcohol-induced functional changes (Crews et al, 2007;Guerri and Pascual 2010;Monti et al, 2005;Philpot et al, 2009;Schindler et al, 2014;Squeglia et al, 2012;Zeigler et al, 2005). Moreover, adolescent alcohol use increases the likelihood of developing an alcohol use disorder (AUD) in adulthood (Blomeyer et al, 2013;Dawson et al, 2008;Hingson et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Spoelder

Tsutsui

Lesscher

et al. 2015

Neuropsychopharmacol

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Adolescent alcohol use remains a major public health concern due in part to well-established findings implicating the age of onset in alcohol use in the development of alcohol use disorders and persistent decision-making deficits in adults. We have previously demonstrated that moderate adolescent alcohol consumption in rats promotes suboptimal decision making and an associated perturbation in mesolimbic dopamine transmission in adulthood. Dopamine-dependent incentive learning processes are an integral component of value-based decision making and a fundamental element to many theoretical accounts of addiction. Thus we tested the hypothesis that adolescent alcohol use selectively alters incentive learning processes through perturbation of mesolimbic dopamine systems. To assess incentive learning, behavioral and neurochemical measurements were made during the acquisition, maintenance, extinction, and reacquisition of a Pavlovian conditioned approach procedure in adult rats with a history of adolescent alcohol consumption. We show that moderate adolescent alcohol consumption potentiates stimulus-evoked phasic dopamine transmission, measured in vivo by fast-scan cyclic voltammetry, in adulthood and biases individuals toward a dopamine-dependent incentive learning strategy. Moreover, we demonstrate that animals exposed to alcohol in adolescence are more sensitive to an unexpected variation in reward outcomes. This pattern of phasic dopamine signaling and the associated bias in learning may provide a mechanism for the well-documented vulnerability of individuals with early-life alcohol use for alcohol use disorders in adulthood.

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“…In contrast to ACTH, cortisol levels remained stable throughout the induction phase. An analogous situation in humans may be the strong effect of early life stress predicting later alcohol abuse (Blomeyer et al, 2013). Further, ACTH increased in all monkeys, whether they subsequently became heavy or nonheavy alcohol drinkers, and therefore was not predictive of subsequent ethanol self-administration (Helms et al, 2013).…”

Section: Stress Response and Endocrine Statusmentioning

confidence: 90%

Drinking to Dependence Risk Factors in Nonhuman Primates

Grant

Ferguson

Helms

et al. 2014

Neurobiology of Alcohol Dependence

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Impact of Pubertal Stage at First Drink on Adult Drinking Behavior

Abstract: The results point to a significant role of stage of pubertal development at first contact with alcohol for the development of later drinking habits. Possible biological mechanisms and implications for prevention are discussed.

Cited by 16 publications

References 37 publications

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Drinking to Dependence Risk Factors in Nonhuman Primates

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