Impact of pubertal onset on region‐specific <i>Esr2</i> expression

Drzewiecki, Carly M.; Sellinger, Elli P.; Juraska, Janice M.

doi:10.1111/jne.13029

Cited by 9 publications

(11 citation statements)

References 62 publications

(91 reference statements)

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“…The pre‐ and post‐pubertal females were littermates at the same age. * p < .05, ** p < .01 (Drzewiecki et al., 2021).…”

Section: The Role Of Pubertymentioning

confidence: 99%

“…This occurred in parallel in both sexes in spite of a main effect of sex such that females had lower PPI scores than males. It is also notable that the age of the post‐pubertal females overlapped the age of the peripubertal males (Drzewiecki, Willing et al., 2021).…”

Section: Timing Within Adolescence Mattersmentioning

confidence: 99%

“…Both peri‐pubertal stressed males and females have lower PPI scores (less sensorimotor gating) than control and post‐pubertal stressed rats. * p < .05, *** p < .001 (Drzewiecki, Willing et al., 2021).…”

Section: Timing Within Adolescence Mattersmentioning

confidence: 99%

“…However, only in the mPFC was the drop complete between the pre‐ and post‐pubertal females at the same age (Figure 9). It is also interesting that the amount of Esr2 mRNA is higher in the mPFC than in the motor cortex and the dorsal striatum at all ages and pubertal status (Drzewiecki et al., 2021).…”

Section: The Role Of Pubertymentioning

confidence: 99%

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The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty

Juraska

2024

Developmental Psychobiology

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There is considerable evidence of reorganization in the prefrontal cortex during adolescence in humans, as well as in rodents, where the cellular basis can be explored. Studies from my laboratory in the rat medial prefrontal cortex are reviewed here. In general, growth predominates before puberty. Pruning mainly occurs at puberty and after with decreases in the number of synapses, dendrites, and neurons. Perineuronal nets, extracellular structures that control plasticity, are pruned peripubertally only in female rats, which may further open the adolescent prefrontal cortex to environmental influences. This is supported by our recent evidence that exposure to mild stress early, but not late, in adolescence decreases prepulse inhibition. Additionally, exposure to methamphetamine in females early in adolescence increases the number of a major class of inhibitory interneurons, parvalbumin neurons, while the opposite occurs late in adolescence. In females, even estrogen receptor beta mRNA decreases at puberty in the prefrontal cortex. Interestingly, rats of both sexes perform better after puberty on a test of cognitive flexibility in the water maze. Thus, evidence is accruing that adolescence is not a single entity but rather an ongoing set of processes, and environmental effects will differ depending on timing and sex.

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“…The pre‐ and post‐pubertal females were littermates at the same age. * p < .05, ** p < .01 (Drzewiecki et al., 2021).…”

Section: The Role Of Pubertymentioning

confidence: 99%

Section: Timing Within Adolescence Mattersmentioning

confidence: 99%

Section: Timing Within Adolescence Mattersmentioning

confidence: 99%

Section: The Role Of Pubertymentioning

confidence: 99%

See 2 more Smart Citations

The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty

Juraska

2024

Developmental Psychobiology

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“…Although using in situ hybridization, a few groups ( 15 , 16 ) detected no expression of ERα and ERβ mRNA in the striatum, the majority of previous studies showed that the expression of estrogen receptors in the rodent dorsal striatum was sparse and was weak to moderate even in positive cells ( 17 – 22 ). In addition, recent findings demonstrate that ERα and ERβ expression are high in mouse pups and decreases with time resulting in low or very low expression in adults ( 23 , 24 ). Finally, ERα and GPER1 were detected in a small proportion of cholinergic interneurons using electron microscopy ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro

et al. 2023

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The striatum is an essential component of the basal ganglia that is involved in motor control, action selection and motor learning. The pathophysiological changes of the striatum are present in several neurological and psychiatric disorder including Parkinson’s and Huntington’s diseases. The striatal cholinergic neurons are the main regulators of striatal microcircuitry. It has been demonstrated that estrogen exerts various effects on neuronal functions in dopaminergic and medium spiny neurons (MSN), however little is known about how the activity of cholinergic interneurons are influenced by estrogens. In this study we examined the acute effect of 17β-estradiol on the function of striatal cholinergic neurons in adult mice in vitro. We also tested the effect of estrus cycle and sex on the spontaneous activity of cholinergic interneurons in the striatum. Our RNAscope experiments showed that ERα, ERβ, and GPER1 receptor mRNAs are expressed in some striatal cholinergic neurons at a very low level. In cell-attached patch clamp experiments, we found that a high dose of 17β-estradiol (100 nM) affected the spontaneous firing rate of these neurons only in old males. Our findings did not demonstrate any acute effect of a low concentration of 17β-estradiol (100 pM) or show any association of estrus cycle or sex with the activity of striatal cholinergic neurons. Although estrogen did not induce changes in the intrinsic properties of neurons, indirect effects via modulation of the synaptic inputs of striatal cholinergic interneurons cannot be excluded.

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Timing of methamphetamine exposure during adolescence differentially influences parvalbumin and perineuronal net immunoreactivity in the medial prefrontal cortex of female, but not male, rats

Brinks,

Carrica,

Tagler

et al. 2023

Preprint

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Adolescence involves significant reorganization within the medial prefrontal cortex (mPFC), including modifications to inhibitory neurotransmission mediated through parvalbumin interneurons (PV) and their surrounding perineuronal nets (PNNs). These developmental changes, which result in increased PV neuron activity in adulthood, may be disrupted by drug use and cause lasting changes in mPFC function and behavior. Methamphetamine (METH), which is a readily available drug used by some adolescents, increases PV neuron activity and could influence the activity-dependent maturational process of these neurons. In the present study, we used male and female Sprague Dawley rats to test the hypothesis that METH exposure influences PV and PNN expression in a sex- and age-specific manner. Rats were injected daily with saline or 3.0 mg/kg METH from early adolescence (EA; 30-38 days old), late adolescence (LA; 40-48 days old), or young adulthood (60-68 days old). One day following exposure, effects of METH on PV cell and PNN expression were assessed using immunofluorescent labeling within the mPFC. METH exposure did not alter male PV neurons or PNNs. Females exposed in early adolescence or adulthood had more PV neurons while those exposed in later adolescence had fewer, suggesting distinct windows of vulnerability to changes induced by METH exposure. In addition, females exposed to METH had more PNNs and more intense PV neuron staining, further suggesting that METH exposure in adolescence uniquely influences development of inhibitory circuits in the female mPFC. This study indicates that the timing of METH exposure, even within adolescence, influences its neural effects in females.

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Impact of pubertal onset on region‐specific Esr2 expression

Cited by 9 publications

References 62 publications

The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty

The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty

17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro

Timing of methamphetamine exposure during adolescence differentially influences parvalbumin and perineuronal net immunoreactivity in the medial prefrontal cortex of female, but not male, rats

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