Impact of psychotic features on morbidity and course of illness in patients with bipolar disorder

Özyıldırım, İlker; Çakιr, Sibel; Yazıcı, Olcay

doi:10.1016/j.eurpsy.2009.08.004

Cited by 32 publications

(18 citation statements)

References 25 publications

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“…Additionally, the smaller number of psychotic participants limited the power of comparisons within this subgroup. In contrast to these results, Ozyildirim et al found that bipolar participants were more likely to respond to lithium when psychosis was not present (Ozyildirim et al, 2010). However, this study differed from the current study in that included only BD-I patients, pooled results of all mood episodes, and compared patients with psychosis in all episodes with those who had never experienced psychosis rather than those who were not currently experiencing it.…”

Section: Discussioncontrasting

confidence: 92%

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Treatment outcomes of acute bipolar depressive episode with psychosis

et al. 2018

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Section: Discussioncontrasting

confidence: 92%

“…associated with reduced recovery rates (Solomon et al, 2010), shorter time to first recurrence (Pallaskorpi et al, 2015;Tohen et al, 2003b), more hospitalizations (Mazzarini et al, 2010;Ozyildirim, Cakir, & Yazici, 2010), and neurocognitive deficits (Tsitsipa & Fountoulakis, 2015).…”

mentioning

confidence: 99%

Treatment outcomes of acute bipolar depressive episode with psychosis

et al. 2018

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“…Psychotic symptoms in BD are predictive of a more detrimental course, including a higher rate of rehospitalizations (Caetano et al, 2006; Ozyildirim et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Fountoulakis

Young

Yatham

et al. 2016

IJNPPY

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Background:This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity.Methods:The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines.Results:The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach. A critical analysis of the existing methods for the grading of treatment options was followed by the development of a new grading method to arrive at efficacy and recommendation levels after the analysis of 32 distinct scenarios of available data for a given treatment option.Conclusion:The current paper reports details on the design, method, and process for the development of CINP guidelines for the treatment of Bipolar Disorder. The rationale and the method with which all data and opinions are combined in order to produce an evidence-based operationalized but also user-friendly guideline and a specific algorithm are described in detail in this paper.

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“…Of note, more than half of the bipolar patients have hallucinations and delusions at least once during a mood episode [2], and patients with major depressive disorder (MDD) may present psychotic symptoms in 19-25% of cases [3] with worse outcomes than patients without psychotic symptoms [4]. The identification of biological markers (e.g.…”

Section: Introductionmentioning

confidence: 99%

Sex Steroids and Major Psychoses: Which Role for DHEA-S and Progesterone?

et al. 2016

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Objective: Endocrine pathways seem to play a role in the etiology of major psychoses. The identification of biomarkers associated with psychotic symptoms in schizophrenia (SKZ) and mood disorders would allow the identification of high-risk subjects for delusions and hallucinations. The aim of this study was to evaluate dehydroepiandrosterone sulfate (DHEA-S) and progesterone plasma levels in drug-free patients with major psychoses and their relation with the diagnosis and history of psychotic symptoms. Methods: Eighty-nine consecutive drug-free male inpatients with SKZ or mood disorders were recruited, and DHEA-S and progesterone plasma levels were measured. The groups, divided according to pathological/normal-range hormone levels, were compared in terms of clinical variables using χ² tests with Bonferroni's corrections or multivariate analyses of variance. The same analyses were performed for groups divided according to the presence/absence of lifetime psychotic symptoms. Binary logistic regression analysis was performed using hormone levels as independent variables and history of lifetime psychotic symptoms as a dependent one. Results: A higher number of patients with abnormal DHEA-S levels was found to have a family history of major depressive disorder (p < 0.05). Higher DHEA-S levels (F = 8.31; p = 0.005) were found in patients with a history of psychotic symptoms. In addition, binary logistic regression confirmed that DHEA-S levels were associated with a higher probability of lifetime psychotic symptoms (p = 0.037). Conclusions: Our results confirm previous data about the role of endocrine factors in the etiology of major psychoses. A high DHEA-S level might be a risk factor for psychotic symptoms. Studies with larger samples are needed to confirm these data.

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Impact of psychotic features on morbidity and course of illness in patients with bipolar disorder

Abstract: The well identified psychotic subtype of bipolar patients may give important predictions about long term course and prophylaxis of bipolar disorder.

Cited by 32 publications

References 25 publications

Treatment outcomes of acute bipolar depressive episode with psychosis

Treatment outcomes of acute bipolar depressive episode with psychosis

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Sex Steroids and Major Psychoses: Which Role for DHEA-S and Progesterone?

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