Impact of psoas muscle index on short-term outcome after living donor liver transplantation

Izumi, Toshio; Watanabe, Jun; Tohyama, Taiji; Takada, Yasutsugu

doi:10.5152/tjg.2016.16201

Cited by 51 publications

(63 citation statements)

References 32 publications

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“…EasyViz ® is an “ultra-thin” web-based PACS client installed enterprise-wide that is easily accessible to bedside clinicians. The psoas index (PI) was measured by summing the right psoas muscle area (RPA) and left psoas area (LPA), to obtain the total psoas area (TPA) then normalizing by the square of the height: PI = (RPA + LPA)/height 2 in cm 2 /m 2 (13). Psoas density was measured as the Hounsfield Unit average calculation, and was determined by summing the product of the right mean psoas Hounsfield Unit density (RPHU) and RPA, with that of the product of the left mean psoas Hounsfield Unit density (LPHU) and LPA, then dividing by the TPA: HUAC = [(RPHU × RPA) + (LPHU × LPA)]/(TPA) in Hounsfield Units(10, 12).…”

Section: Methodsmentioning

confidence: 99%

“…Thus, several groups have proposed using direct imaging measures of sarcopenia as an objective and easy to measure marker of physiologic reserve(8–13). Several studies have validated the computed tomography (CT) psoas muscle measurements at the L3 vertebral level as a predictor of poor outcomes in multiple settings including liver transplantation, and oncologic surgery(8–13).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have validated the computed tomography (CT) psoas muscle measurements at the L3 vertebral level as a predictor of poor outcomes in multiple settings including liver transplantation, and oncologic surgery(8–13). In addition, recent studies have found that CT psoas density, which focuses on measuring muscle quality and degree of age-related fatty muscular infiltration rather than gross mass, can be used to predict mortality in gastrointestinal oncologic surgery(10, 12).…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography measured psoas density predicts outcomes in trauma

Yoo

Evans

2017

Surgery

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Background Age-related loss of muscle mass and function (sarcopenia) is linked to poor outcomes after surgery and trauma. Here we evaluate CT measured psoas muscle density and area using quick and simple tools available to the beside clinician. We hypothesize these measures will predict poor outcomes after blunt traumatic injury. Methods We conducted a retrospective cohort study of patients ages ≥ 45 years in the Ohio State University Trauma Registry in 2008 that received a CT abdomen/pelvis with intravenous contrast. Psoas Index (PI) and Hounsfield Unit average calculation (HUAC) were measured at the L3 level. 90-day mortality, complication, length of stay ≥ 7 days, dependent discharge were compared to PI and HUAC. Results 151 patients met inclusion criteria. Patients were stratified into interquartile ranges based either on PI or HUAC values. After adjustment with sex-specific cutoffs, the lowest interquartile range of PI was associated with 90-day mortality (RR 5.95, p < 0.008) but did not reach significance in other outcomes. The lowest interquartile range of HUAC was associated with 90-day mortality (RR 5.95, p < 0.008) length of stay ≥ 7 days (RR 1.63, p = 0.048), complication risk (RR 2.30, p = 0.002), and dependent discharge 2.14, p = 0.015). Conclusion Psoas muscle density is a significant predictor of poor outcomes after traumatic injury. This objective, quick, and readily available measure of sarcopenia can identify patients requiring aggressive nutritional and physical therapy to improve prognosis, prevent recurrent traumatic injury, and aid in discharge planning.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computed tomography measured psoas density predicts outcomes in trauma

Yoo

Evans

2017

Surgery

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“…Cancer patients are prone to sarcopenia as a result of the decrease in muscle mass and muscle weakness which occurs in cancer cachexia (2, 3). Sarcopenia can also be diagnosed by measuring the psoas muscle area (4,5). Although nutritional management of cancer patients to prevent and resolve sarcopenia has not been established, attention has been focused on the effects of fatty acid administration on cancer patients (6)(7)(8).…”

mentioning

confidence: 99%

Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 1003-1009 Elevated Serum AA/EPA Ratio as a Predictor of Skeletal Muscle Depletion in Cachexic Patients with Advanced Gastro-intestinal Cancers

Kitagawa

Haji

Amagai

2018

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“…In LDLT settings, preoperative sarcopenia, determined by measurement of skeletal muscle mass (SMM), was related to short‐term mortality, and the SMM decreased postoperatively and did not reach the basal level within 1 year after surgery . Another study showed that low PMI before LDLT was correlated with postoperative complications, including Clavien‐Dindo classification (grade ≥ 3a) and 120‐day mortality . The present study suggested that the degree of decrease in PMI between the day before surgery and POD 7 influences overall patient mortality in the follow‐up period after LDLT.…”

Section: Discussionmentioning

confidence: 57%

Perioperative loss of psoas muscle is associated with patient survival in living donor liver transplantation

et al. 2018

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Patients with end-stage liver disease show sarcopenia, and preoperative sarcopenia is independently associated with patient mortality after liver transplantation. However, few studies have examined the relationship between perioperative loss of core muscle and patient mortality in living donor liver transplantation (LDLT). This study was performed to investigate the association between a perioperative decrease in the psoas muscle index (PMI) and patient mortality after LDLT. Adult patients (age ≥ 18 years) undergoing LDLT between January 2009 and December 2016 were classified into low-loss (>25th quartile) versus high-loss (≤25th quartile) groups according to PMI change between the day before surgery and postoperative day (POD) 7. Patient survival was compared between the 2 groups, and factors affecting survival were analyzed. The median (interquartile range) level of PMI change from the day before surgery to POD 7 was -4.8% (-11.7%-1.2%). Although there was no preoperative difference in PMI between the low-loss and high-loss groups, patients with PMI change ≤-11.7% showed poorer survival than those with PMI change >-11.7% during the follow-up period. A PMI decrease ≤-11.7% between the day before surgery and POD 7 is an independent predictor of patient mortality after LDLT. In addition, intraoperative packed red blood cell transfusion, graft fat percentage, and reoperation and infection after surgery were significantly associated with patient mortality. In conclusion, a PMI decrease ≤-11.7% between the day before surgery and POD 7 is an independent predictor of patient mortality after LDLT. It is necessary to identify the factors responsible for the perioperative decrease in skeletal muscle mass and to ascertain if they are modifiable to improve patient survival after LDLT. Liver Transplantation 24 623-633 2018 AASLD.

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Impact of psoas muscle index on short-term outcome after living donor liver transplantation

Cited by 51 publications

References 32 publications

Computed tomography measured psoas density predicts outcomes in trauma

Computed tomography measured psoas density predicts outcomes in trauma

Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 1003-1009 Elevated Serum AA/EPA Ratio as a Predictor of Skeletal Muscle Depletion in Cachexic Patients with Advanced Gastro-intestinal Cancers

Perioperative loss of psoas muscle is associated with patient survival in living donor liver transplantation

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