Abstract:Posttranslational modifications of proteins can impact
their therapeutic
efficacy, stability, and potential for pharmaceutical development.
The Group AStreptococcus pyogenesC5a
peptidase (ScpA) is a multi-domain protein composed of an N-terminal
signal peptide, a catalytic domain (including propeptide), three fibronectin
domains, and cell membrane-associated domains. It is one of several
proteins produced by Group AS. pyogenesknown to cleave components of the human complement system. After
signal peptide remov… Show more
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