Impact of preprocedure simethicone on adenoma detection rate during colonoscopy: a multicenter, endoscopist-blinded randomized controlled trial

Bai, Yu; Fang, Jun; Zhao, Shengbing; Wang, Dong; Li, Yanqing; Shi, Ruihua; Sun, Zhaoxia; Sun, Mingjun; Ji, Feng; Si, Jianmin

doi:10.1055/s-0043-119213

Cited by 40 publications

(98 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result of meta‐analysis of ADR is in accordance with results of studies conducted by Bai et al . and Zhang et al ,.…”

Section: Discussionsupporting

confidence: 89%

“…Better bowel preparation makes it possible to find smaller adenomas. Bai et al . reported 94 adenomas (size ≤ 5 mm) in the SIM group versus 40 in the non‐SIM group, Pontone et al .…”

Section: Discussionmentioning

confidence: 99%

“…In order to improve the level of bowel cleansing, simethicone (SIM), a kind of oral antifoaming agent, has been added to several PEG‐based bowel preparation regimens, for it reduces bubbles in bowel segments so as to improve visualization of the colonic mucosa and promote emission of excessive gas …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of supplemental simethicone for bowel preparation on adenoma detection during colonoscopy: A meta‐analysis of randomized controlled trials

Pan

Zhao

et al. 2018

J of Gastro and Hepatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The result of meta‐analysis of ADR is in accordance with results of studies conducted by Bai et al . and Zhang et al ,.…”

Section: Discussionsupporting

confidence: 89%

“…Better bowel preparation makes it possible to find smaller adenomas. Bai et al . reported 94 adenomas (size ≤ 5 mm) in the SIM group versus 40 in the non‐SIM group, Pontone et al .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of supplemental simethicone for bowel preparation on adenoma detection during colonoscopy: A meta‐analysis of randomized controlled trials

Pan

Zhao

et al. 2018

J of Gastro and Hepatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our search strategy identified 535 potentially relevant records after excluding duplicates. After careful review, 36 studies that met inclusion criteria were further evaluated for eligibility, and 12 full‐text articles from 2009 to 2017 were included in this meta‐analysis . The review process is illustrated by a flowchart of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…One meta‐analysis showed that oral simethicone helps reduce bubbles and improves visibility in upper gastrointestinal endoscopy, but the ADR was not evaluated because few studies had addressed this issue at the time it was published. Several subsequent randomized controlled trials evaluated the bowel cleansing effects of adjuvant simethicone; however, whether it had a beneficial role in ADR or polyp detection rate (PDR) had yet to be confirmed …”

Section: Introductionmentioning

confidence: 99%

The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta‐analysis

Yeh

Hsu

Tseng

et al. 2018

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim Simethicone is an anti‐foaming agent commonly used during colonoscopy. Although several randomized trials have shown that oral simethicone in the bowel preparation regimen may improve bowel cleanness, whether it improves adenoma detection rate (ADR) or polyp detection rate remains undetermined. The aim of this study was to determine if oral simethicone in bowel preparation regimen before colonoscopy improves the ADR. Methods A comprehensive literature review was conducted using PubMed, SDOL, Cochrane Library, and ProQuest databases through December 2017. Randomized controlled trials that compared bowel preparation regimens with simethicone versus those without it were included. Effect estimates from each study were extracted and underwent meta‐analysis using appropriate models. The primary outcomes were ADR and polyp detection rate, and secondary outcomes included bowel preparation, bubble score, and withdrawal time. Results Twelve published randomized controlled studies with 6003 participants were included for meta‐analysis. There was no difference in the overall ADR (pooled risk ratio = 1.06, 95% confidence interval = 0.91–1.24) and right‐side ADR (risk ratio = 1.50, 95% confidence interval = 0.82–2.75) between the groups with or without simethicone. However, the addition of simethicone improved adenoma detected per patient (2.20 ± 1.36 vs 1.63 ± 0.89) according to one of the included studies. Meta‐regression revealed that the baseline ADR < 25% of the included studies was associated with significant benefit of oral simethicone; the number needed to treat was 15. Conclusions The adjunction of oral simethicone significantly improved bowel preparation quality and might benefit adenoma detection in specific settings with low baseline ADR.

show abstract

Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles

et al. 2021

View full text Add to dashboard Cite

Background: Intraluminal bubbles may prevent the visualisation of mucosa during a colonoscopy. Simethicone minimises bubbles, but its impact on incomplete bowel preparation and optimal protocols for use are unclear. Aim:To assess the impact of oral simethicone tablets when added to 2-litre, splitprep, polyethylene glycol electrolyte lavage solution + ascorbic acid on bubble score and frequency of incomplete bowel preparation.Methods: This QA/QI project assessed outpatients who underwent colonoscopy at the Veterans Affairs Ann Arbor Healthcare System. After endoscopists were trained in intraluminal bubble scoring systems, data about bubble score, frequency of inadequate bowel preparation requiring early repeat colonoscopy, quality of bowel preparation using Boston Bowel Preparation Scale (BBPS), and patient tolerance were collected before and after addition of oral simethicone 160mg to each dose of 2-litre split-prep.Results: There were no differences in patient characteristics between the baseline group (n = 348) and the simethicone group (n = 354). Simethicone improved the total mean intraluminal bubble score from 8.18 to 8.78 (P < 0.001). Early repeat colonoscopy due to inadequate bowel preparation was higher in the baseline group vs simethicone group: 8.7% vs 4.6%, P = 0.03 with an RRR = 0.5 (95% CI 0.26-0.95).Using BBPS, the frequency of having inadequate cleansing in any colon segment was higher in the baseline group vs simethicone group: 6.6% vs 3.1%; RRR = 0.55 (95% CI 0.21-0.94). | 255 MARATT eT Al. How to cite this article: Maratt JK, Freeman AE, Schoenfeld P, et al. Oral simethicone tablets with PEG-ELS split-prep reduces frequency of inadequate bowel cleansing and decreases

show abstract

Impact of preprocedure simethicone on adenoma detection rate during colonoscopy: a multicenter, endoscopist-blinded randomized controlled trial

Abstract: Combined use of PEG and simethicone is associated with a significantly increased ADR in a Chinese population.

Cited by 40 publications

References 34 publications

Effect of supplemental simethicone for bowel preparation on adenoma detection during colonoscopy: A meta‐analysis of randomized controlled trials

Effect of supplemental simethicone for bowel preparation on adenoma detection during colonoscopy: A meta‐analysis of randomized controlled trials

The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta‐analysis

Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles

Contact Info

Product

Resources

About