Impact of Preoperative Serum Carcinoembryonic Antigen, CA 19-9 and Alpha Fetoprotein Levels in Gastric Cancer Patients

Nakajima, Kiyokazu; Ochiai, Takenori; Suzuki, Takao; Shimada, Hideaki; Hayashi, Hideki; Yasumoto, Akihiko; Takeda, Akihiko; Hishikawa, Etsuo; Isono, Kaichi

doi:10.1159/000030038

Cited by 44 publications

(44 citation statements)

References 11 publications

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“…However, the preoperative serum CEA level has been reported to function as a useful marker for the prognosis of these tumors [3,4]. The positivity rate of CEA in our study was 15.9%, which is lower than the data reported by other investigators [8][9][10][11]. The positivity rate of CA 19-9 was 32.9%, which is also lower than in other studies [9,10].…”

Section: Discussioncontrasting

confidence: 78%

Prognostic Value of Carcinoembryonic Antigen, CA 19-9 and CA 72-4 in Gastric Carcinoma

Gaspar¹,

Arribas²,

Coca³

et al. 2001

Tumor Biol

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The prognostic value of preoperative serum levels of carcinoembryonic antigen (CEA), CA 19-9 and CA 72-4 tumor markers was investigated in patients with gastric cancer. Eighty-two patients who underwent surgical resection of gastric cancer were entered in the study. Correlation analyses showed that CA 72-4 was more frequently positive in patients with advanced tumors (p = 0.04), lymph node invasion (p = 0.02), liver metastasis (p = 0.02) and peritoneal involvement (p = 0.03). CA 19-9 was more frequently positive in patients with advanced tumors (p = 0.01) and with serosal (p = 0.04), lymph node (p = 0.008) and peritoneal involvement (p = 0.02). CEA was more frequently positive in patients with liver metastasis (p = 0.03). Low 3-year cumulative survival was significantly associated with elevated serum levels of CA 72-4 (p = 0.004), CA 19-9 (p = 0.001) and CEA (p < 0.001). Age, tumor stage and CA 72-4 provided prognostic information in the multivariate analysis. Patients with elevated serum levels of CA 72-4 showed a 4.2 times higher risk of death than patients with low levels of the marker. Our results suggest that CA 72-4 has prognostic value in gastric cancer, and patients with a high preoperative serum level of CA 72-4 have a greater risk of death due to gastric cancer.

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Section: Discussioncontrasting

confidence: 78%

Prognostic Value of Carcinoembryonic Antigen, CA 19-9 and CA 72-4 in Gastric Carcinoma

Gaspar¹,

Arribas²,

Coca³

et al. 2001

Tumor Biol

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“…However, the related literature describes some different observations. Nakajima et al 17 reported that there was no correlation between preoperative afp values and histopathology, lymph node metastasis, vessel invasion, and liver metastasis. Lymph node involvement has been reported to be present in 62.9%-100% patients with afpgc 11-15 .…”

Section: Discussionmentioning

confidence: 99%

Clinical Manifestations in Patients with Alpha-Fetoprotein–Producing Gastric Cancer

et al. 2014

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Backgroud: Patients with alpha-fetoprotein (afp)–producing gastric cancer have a high incidence of liver metastasis and poor prognosis. There is some controversy about clinical manifestations in these patients. Methods: Our study enrolled patients who, before surgery, had gastric cancer with serum afp exceeding 20 ng/mL [afp>20 (n = 58)] and with serum afp 20 ng/mL or less [afp≤20 (n = 1236)]. Clinical manifestations were compared between the groups. Results: Early gastric cancer was more frequent (30.1% vs. 4%) and advanced gastric cancer was less frequent (69.9% vs. 96%) in the afp≤20 group than the afp>20 group (p < 0.001). Liver and lymph node metastasis occurred less frequently in the afp≤20 group (4.4% vs. 27.6%, p < 0.001, and 60.7% vs. 91.4%, p < 0.001, respectively). The 1-, 3-, 5-, and 10-year survival rates of afp≤20 patients were 75.2%, 53.4%, 45.8%, and 34.6% respectively. The 1-, 3-, 5-, and 10-year survival rates of patients with afp greater than 20 ng/mL, but 300 ng/mL or less, were 46.7%, 28.9%, 17.8%, and 13.3% respectively. The 1-, 3-, and 5-year survival rates of patients with serum afp greater than 300 ng/mL were 15.4%, 7.7%, and 0% respectively. The independent predictors for survival time were afp concentration, age, peritoneal seeding, liver metastasis, lymph node metastasis, vascular invasion, TNM stage, curative surgery, serosal invasion, and Lauren classification. Conclusions: Patients with high serum afp had a high frequency of liver and lymph node metastasis and very poor prognosis. More aggressive management with multimodal therapy (for example, chemotherapy, radiotherapy) might be needed when treating such patients.

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“…A few serum markers were found to be associated with poor prognosis in patients with gastric cancer and are therefore useful for monitoring and predicting early recurrence and poor prognosis [1,2]. The host infl ammatory response to cancer cells is also associated with tumor progression [3,4].…”

Section: Introductionmentioning

confidence: 99%

High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer

et al. 2010

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Background. The neutrophil-lymphocyte ratio (NLR) refl ects infl ammatory status. An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical signifi cance of the preoperative NLR in patients with primary gastric cancer. Results. The 5-year survival of patients with a high NLR was signifi cantly worse than that of patients with a low NLR (57% vs 82%, P < 0.001). Univariate and multivariate analyses of clinicopathological factors affecting survival revealed that high NLR, depth of tumor, positive lymph nodes, distant metastasis, peritoneal metastasis, poorly differentiated type, and high platelet count were signifi cant risk factors for reduced survival. On multivariate analysis, after adjusting for tumor stage, a high NLR was an independent risk factor for reduced survival (P = 0.003; adjusted hazard ratio, 1.845; 95% confidence interval, 1.236-2.747). Conclusion. A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for primary gastric cancer.

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Impact of Preoperative Serum Carcinoembryonic Antigen, CA 19-9 and Alpha Fetoprotein Levels in Gastric Cancer Patients

Cited by 44 publications

References 11 publications

Prognostic Value of Carcinoembryonic Antigen, CA 19-9 and CA 72-4 in Gastric Carcinoma

Prognostic Value of Carcinoembryonic Antigen, CA 19-9 and CA 72-4 in Gastric Carcinoma

Clinical Manifestations in Patients with Alpha-Fetoprotein–Producing Gastric Cancer

High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer

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