Impact of Preoperative Nutritional Status on Long-term Survival in Patients With Stage I-III Colorectal Cancer

Abstract

Background/Aim: In addition to oncological and treatment factors, the outcomes of cancer treatment are greatly influenced by host factors, such as the nutritional status. The aim of this study was to evaluate the association between the preoperative nutritional status and the prognosis of colorectal cancer patients using three nutritional indices. Patients and Methods: The target cohort consisted of 529 patients with stage I-III colorectal cancer, who underwent curative surgery between January 2015 and December 2019. The nutritional indices were calculated according to the equations that follow. Prognostic nutritional index (PNI)=10×serum albumin concentration (g/dl) +0.005×peripheral lymphocyte count (/μl). Nutritional risk index (NRI)=15.19×serum albumin concentration (g/dl)+41.7×present weight/usual weight. Geriatric nutritional risk index (GNRI)=14.89×serum albumin concentration (g/dl)+41.7×present weight/ideal weight. Ideal weight was calculated as follows: height(cm)-100-[(height(cm)-150)/4] for men and height(cm)-100-[(height(cm)-150)/2.5] for women. Results: In common with all nutritional indices (PNI, NRI and GNRI), the low-nutritional index group had significantly lower relapse-free and overall survival rates than the high-nutritional index group. Furthermore, a subgroup analysis according to the NRI showed the association of the NRI with the patient prognosis for each stage. Conclusion: The preoperative nutritional status may have a close relationship with the prognosis in patients who receive curative surgery for colorectal cancer. Patients and MethodsPatients. The target cohort consisted of 529 patients with stage I-III colorectal cancer, who underwent curative surgery at the

Association of Geriatric Nutritional Risk Index With Adverse Event and Treatment Duration in Adjuvant Chemotherapy for Patients With Colorectal Cancer

“…In gastric cancer, it has been reported that improved preoperative nutritional status contributes to fewer postoperative complications and shorter hospital stays (3,23). In colorectal cancer and liver metastases of colorectal cancer, preoperative nutritional status has also been reported to influence postoperative complications and survival (24)(25)(26)(27), and to be a predictor of recurrence and poor prognosis in elderly patients with rectal cancer undergoing radical resection after preoperative chemotherapy (neoadjuvant chemotherapy) (28). Therefore, we believe that GNRI, a useful method of assessing nutritional status, is a factor that influences the duration of surgery and cancer chemotherapy treatment in gastric and colorectal cancer.…”