Impact of preoperative low prognostic nutritional index and high intramuscular adipose tissue content on outcomes of patients with oral squamous cell carcinoma

Yoshimura, Tsuyoshi; Suzuki, Hajime; Takayama, Hirotaka; Higashi, Shotaro; Hirano, Yuka; Tezuka, Masahiro; Ishida, Takayuki; Nakamura, Yasunori; Nozoe, Etsuro; Nakamura, Norifumi

doi:10.5794/jjoms.67.410

Cited by 3 publications

(6 citation statements)

References 39 publications

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“…An increasing number of studies have shown that skeletal muscle loss (sarcopenia) is an indicator of poor prognosis in cancer patients (17,(20)(21)(22). However, in previous studies, researchers often focused on the skeletal muscle mass (17,(20)(21)(22), such as CT plane measurement of skeletal…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of skeletal muscle cross-sectional area (cm 2 ) and CT values (Hounsfield units) in the L3 plane region using ImageJ software. IMAC and psoas muscle mass index (PMI) are calculated according to the method previously reported (14,17). The multifidus muscle was accurately depicted on the L3 level CT image, and its CT value was calculated by ImageJ software (Figure 1).…”

Section: Image Analysismentioning

confidence: 99%

“…(II) LABORATORY parameters, including carbohydrate antigen 19-9 (CA19-9), serum triglyceride, albumin, lymphocyte absolute value, neutrophil absolute value, high-density lipoprotein (HDL), and total bilirubin. Using laboratory parameters we calculated the prognostic nutritional index (PNI) and the fibrinogen albumin ratio (FAR), which were considered to be associated with the prognosis of numerous tumor patients (17)(18)(19)(20). (III) Pathological parameters, including TNM stage (AJCC 8 th ) and tumor differentiation.…”

Section: Clinical and Operative Characteristicsmentioning

confidence: 99%

“…Although many reports are suggesting that sarcopenia is a factor in the poor prognosis of many tumor patients (17,(20)(21)(22), the mechanism involved remains unclear. The homeostasis of skeletal muscle is sustained by protein synthesis and lecture (27).…”

Section: Hazard Ratio (95% Ci)mentioning

confidence: 99%

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Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

Zheng¹,

Chen²,

Zhang³

et al. 2022

Transl Cancer Res TCR

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Background: To investigate the predictive value of intramuscular adipose tissue content (IMAC) on the outcome of gallbladder cancer (GBC) patients after resection, by then develop and evaluate a nomogram to predict the prognosis of GBC patients. Methods: This research incorporated 123 patients with a pathological diagnosis of GBC. Evaluating the prognosis by the Kaplan-Meier method. Independent predictors of overall survival (OS) were screened using multifactorial Cox regression analysis, and a nomogram was constructed from these. Consistency index and calibration curve were used to identify and calibrate the nomogram. The accuracy of the nomogram was assessed by receiver operating characteristic (ROC) curve and decision curve analysis (DCA) was used to assess the net benefit. Results: Patients with high IMAC showed a worse prognosis. A nomogram was constructed to predict OS based on IMAC. The C-index for the nomogram was 0.804. The calibration curve showed well performance of the nomogram. The area under the ROC curve (AUC) for the nomogram at three and five years was 0.839 and 0.785, respectively. A high net benefit was demonstrated by DCA.Conclusions: IMAC was a valid predictor for GBC patients. A nomogram with good performance is constructed to predict the prognosis of GBC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

Section: Clinical and Operative Characteristicsmentioning

confidence: 99%

Section: Hazard Ratio (95% Ci)mentioning

confidence: 99%

See 2 more Smart Citations

Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

Zheng¹,

Chen²,

Zhang³

et al. 2022

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…By examining the laboratory data of patients enrolled in our study and Iida et al, we found that our OSCC cohort had a 3.6-fold higher median serum CRP level compared with that of patients with HCC reported by Iida et al (0.36 vs. 0.10 mg/dL) 17 , which can be partially explained by increased oral and systemic inflammation resulting from oral microbiota 49 . In addition, patients with OSCC are susceptible to malnutrition 50 and food intake dysfunction 51 and therefore have a decreased serum albumin level. All these factors may contribute to the lower cutoff value for the CALLY index in our study than the cutoff reported for the HCC cohort.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Oral Cavity Cancer

Tsai¹,

Ko²,

Chen³

et al. 2022

J. Cancer

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Background:The prognostic value of the CRP-albumin-lymphocyte index (CALLY index) was analyzed in patients with oral cavity squamous cell carcinoma (OSCC) undergoing curative surgery. Methods: We retrospectively included 279 patients who were diagnosed as having primary OSCC and being treated with surgery. The optimal cutoff for the preoperative CALLY index was identified by considering the area under the receiver operating characteristic curve; subsequently, the discriminatory ability of the cutoff was determined. We employed Kaplan-Meier analysis and the log-rank test to elucidate associations between the CALLY index and survival outcomes. We identified prognostic variables by using the Cox proportional hazards model. Finally, we devised a nomogram based on the CALLY index for predicting individualized survival. Results: The cutoff value of the CALLY index was determined to be 0.65. A CALLY index < 0.65 exhibited a significant association with pathological aggressiveness as well as shorter overall and disease-free survival (OS and DFS, both P < 0.001). A low CALLY index was an independent risk factor for short OS and DFS [hazard ratio = 3.816; 95% confidence interval (CI) 2.393-6.086; P < 0.001; and hazard ratio = 2.103; 95% CI 1.451-3.049; P < 0.001, respectively] in multivariate Cox analysis. The prognostic nomogram based on the CALLY index yielded accurate predictions of OS, as revealed by a concordance index of 0.797. Conclusions:The preoperative CALLY index is easy and inexpensive to calculate and, in patients with OSCC, can be a valuable prognostic biomarker. The CALLY-index-based nomogram established in this study provides accurate survival predictions.

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Impact of Sarcopenia on Head and Neck Cancer Treatment: A Review of Literature

Kantamani,

Bavaskar,

Shetty

et al. 2023

Indian J Med Paediatr Oncol

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The overall outcome of head and neck cancer (HNC) patients undergoing any treatment modality may significantly depend upon their general nutritional condition. Poor nutritional status leading to sarcopenia may be a negative prognostic factor in determining the outcome of HNC patients. PubMed database was searched to identify studies published between 2015 and 2022. All studies reporting the index for sarcopenia as well as its effect on HNC were included. This narrative review was conducted to specifically evaluate the impact of sarcopenia on HNC patients undergoing surgery/ free flap reconstruction/ adjuvant treatment. In oncology, computed tomography assessment of skeletal mass at C3 and L3 is the most suitable index to detect sarcopenia. From the articles yielded, the prevalence rate of sarcopenia ranges from 6 to 70% worldwide. Indian population presents with a significantly higher rate of 31.5% sarcopenia HNC patients. Sarcopenic patients have an increased propensity for surgical site infections, as high as 24.6% owing to the reduced skeletal muscle mass. These patients are also prone to have frequent breaks during radiation treatment of more than 1 week and increased chemotherapy-related toxicities. Further, sarcopenic individuals tend to have higher Ryle's tube dependency of more than 90 days. Sarcopenic patients undergoing surgery have a poor overall survival (OS) and disease-free survival (DFS). In terms of hazards ratio, sarcopenic patients have 1.96 times poor OS and 2.00 times poor DFS when compared to normal individuals who undergo HNC surgery. Sarcopenia is an indispensable part of cancer ailment and it is an independent factor negatively influencing DFS and OS. Thus, nutritional strategy needs to be developed to mitigate sarcopenic effects, especially in the Indian population in preoperative setting.

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Impact of preoperative low prognostic nutritional index and high intramuscular adipose tissue content on outcomes of patients with oral squamous cell carcinoma

Cited by 3 publications

References 39 publications

Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Oral Cavity Cancer

Impact of Sarcopenia on Head and Neck Cancer Treatment: A Review of Literature

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