Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome

Cossío, Lourdes Fernández de; Fourrier, Célia; Sauvant, Julie; Everard, Amandine; Capuron, Lucile; Cani, Patrice D.; Layé, Sophie; Castanon, Nathalie

doi:10.1016/j.bbi.2016.12.022

Cited by 84 publications

(63 citation statements)

References 91 publications

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“…In agreement with our results obtained in the high-sucrose diet group, obese subjects have shown higher resistin concentrations than non-obese controls [72, 73]. Also in accordance with our findings, higher levels of resistin were found in the db/db mice [74], which also models MS [8]. Since the role of this adipokine on anxiety and depression has been scarcely explored [75], further investigation is needed to determine the possible role of leptin resistance or hyperleptinemia and increased plasma levels of resistin in the increased anxiety-like behavior observed in our MS model.…”

Section: Discussionsupporting

confidence: 93%

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

et al. 2017

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Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.

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Section: Discussionsupporting

confidence: 93%

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

et al. 2017

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“…FOS are nondigestible carbohydrates and may exert a significant dose-dependent influence on the animal. For example, low-dose FOS supplementation can improve glycemic dysregulations and blood-brain-barrier integrity in mice [60], whereas high-dose FOS supplementation may lead to deteriorated glucose metabolism [61]. Consistent with these patterns, our low FOS supplementation (5%) substantially increased the body mass of voles by promoting SCFAs production, but we found no significant effects of 10% FOS supplementation.…”

Section: Discussionsupporting

confidence: 74%

Host-microbiota interaction helps to explain the bottom-up effects of climate change on a small rodent species

Yin

et al. 2020

The ISME Journal

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The population cycles of small rodents have puzzled biologists for centuries. There is a growing recognition of the cascading effects of climate change on the population dynamics of rodents. However, the ultimate cause for the bottom-up effects of precipitation is poorly understood, from a microbial perspective. Here, we conducted a precipitation manipulation experiment in the field, and three feeding trials with controlled diets in the laboratory. We found precipitation supplementation facilitated the recovery of a perennial rhizomatous grass (Leymus chinensis) species, which altered the diet composition and increase the intake of fructose and fructooligosaccharides for Brandt's vole. Lab results showed that this nutrient shift was accompanied by the modulation of gut microbiota composition and functional pathways (especially for the degradation or biosynthesis of L-histidine). Particularly, the relative abundance of Eubacterium hallii was consistently increased after feeding voles with more L. chinensis, fructose or fructooligosaccharide. These modulations ultimately increased the production of short chain fatty acids (SCFAs) and boosted the growth of vole. This study provides evidence that the precipitation pulses cascades through the plant community to affect rodent gut microbiome. Our results highlight the importance of considering host-microbiota interaction when investigating rodent population responses to climate change.

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“…For example, GOS stimulated growth of bifido bacteria in the mouse gut led to modulation of cortical IL 1β and 5 HT 2A receptor expression and reduced anx iety levels 63 , as well as enhancing brain barrier function in obese mice 64 . Similarly, utilization of prebiotics might also reduce blood ammonia levels and improve psychometric tests in patients with hepatic encephalopathy 65 , presum ably through the formation of relevant bacterial metabo lites.…”

Section: Prebiotic Utilization and Host Healthmentioning

confidence: 99%

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson

Hutkins

Sanders³

et al. 2017

Nat Rev Gastroenterol Hepatol

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In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation

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Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome

Cited by 84 publications

References 91 publications

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

Host-microbiota interaction helps to explain the bottom-up effects of climate change on a small rodent species

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

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