Impact of Pre-operative Aerobic Exercise on Cardiometabolic Health and Quality of Life in Patients Undergoing Bariatric Surgery

Gilbertson, Nicole M.; Eichner, Natalie Z.M.; Khurshid, Mahnoor; Rexrode, Elizabeth A.; Kranz, Sibylle; Weltman, Arthur; Hallowell, Peter T.; Malin, Steven K.

doi:10.3389/fphys.2020.01018

Cited by 15 publications

(20 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is an exploratory study and previously published methods are briefly outlined here for ease of the reader (Gilbertson et al, 2020a(Gilbertson et al, , 2020b. In short, participants were included in the study if they were 18-70 years old undergoing their first Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) procedure, not pregnant or lactating, and not taking medications known to alter body weight.…”

Section: Study Participantsmentioning

confidence: 99%

“…Participants were match-paired between EX + SC or SC based on body mass index (BMI), sex, race, and surgery type (RYGB or SG). Outcomes were assessed pre-intervention, ~2 days before surgery (i.e., post-intervention), and 30 days postsurgery (Gilbertson et al, 2020a(Gilbertson et al, , 2020b. Thirty days post-bariatric surgery is commonly studied in patients to evaluate the short-term effect of bariatric surgery on cardiometabolic health (Karamanakos et al, 2008;Livingston and Fink, 2003;Rizzello et al, 2010;Samat et al, 2013;Streese et al, 2019).…”

Section: Study Participantsmentioning

confidence: 99%

“…VO 2 peak was tested using indirect calorimetry on a treadmill (Carefusion, Vmax CART). Participants self-selected a speed and grade was increased 2.5% every 2 min until volitional exhaustion as reported before (Gilbertson et al, 2020a(Gilbertson et al, , 2020b).…”

Section: Body Composition and Cardiorespiratory Fitnessmentioning

confidence: 99%

“…Participants were educated to avoid alcohol, caffeine, dietary supplements, medication, and exercise for 24 h prior to testing (Gilbertson et al, 2020a(Gilbertson et al, , 2020b. Following an overnight fast, participants were admitted at approximately 8:00 a.m. to the Clinical Research Unit.…”

Section: Mixed Meal Tolerance Testmentioning

confidence: 99%

“…A low calorie diet is current standard medical care (SC) prior to bariatric surgery to reduce liver size prior to surgery and improve surgical outcomes (Colles et al, 2006;Edholm et al, 2011). Aerobic exercise has proven to be an effective intervention to improve cardiometabolic health in obese adults as well as other clinical populations (2018 Physical Activity Guidelines Advisory Committee, 2018; Lin et al, 2015), and recently aerobic exercise has gained attention for not only reducing surgical risk, but also increasing cardiometabolic health and QoL in bariatric patients (Baillot et al, 2013(Baillot et al, , 2016Gilbertson et al, 2020aGilbertson et al, , 2020b. We recently showed that individuals completing 30 days of aerobic exercise combined with standard care (EX + SC) prior to bariatric surgery had a shorter length of hospital stay than individuals undergoing SC (Gilbertson et al, 2020b).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery

Gilbertson

Eichner

Gaitán

et al. 2021

Physiological Reports

Self Cite

View full text Add to dashboard Cite

We evaluated the effect of preoperative standard medical care (SC) vs. unsupervised aerobic exercise combined with SC (EX + SC) on cardiometabolic health and quality of life (QoL) 30 days after bariatric surgery. Bariatric patients (n = 14, age: 42.3 ± 2.5 years, body mass index: 45.1 ± 2.5 kg/m2) were match‐paired to presurgical SC (n = 7) or EX + SC (n = 7; walking 30 min/day, 5 day/week, 65–85% HRpeak) for 30 days. Body composition, peak cardiorespiratory fitness (VO2peak), QoL, inflammation (adiponectin, leptin, cytokeratin‐18), and a 120 min mixed meal tolerance test was performed to assess aortic waveforms (augmentation index, AIx@75), insulin sensitivity, and glucose total area under the curve (tAUC) at the time of surgery (post‐intervention) and 30 days post‐surgery. EX + SC had significantly higher high molecular weight (HMW) adiponectin (p = 0.01) and ratio of HMW to total adiponectin (p = 0.04) than SC at 30 days post‐surgery, although they significantly (p = 0.006; ES = 1.86) decreased total time spent in moderate to vigorous physical activity (MVPA). SC had a significantly greater increase in VO2peak (p = 0.02; ES = 1.54) and decrease in 120 min AIx@75 (p = 0.02; ES = 1.78) than EX + SC during the post‐surgical period. The increase in MVPA was associated with a reduction in cytokeratin‐18 (r = −0.67, p = 0.02). Increased VO2peak was associated with increased activity/mobility QoL domain (r = 0.52, p = 0.05) and decreased 120 min AIx@75 (r = −0.61, p = 0.03) from surgery to post‐surgery. Preoperative EX + SC did not maintain more favorable cardiometabolic health 30 days post‐operation in this pilot study. However, changes in MVPA appear important for QoL and should be considered in future work.

show abstract

Section: Study Participantsmentioning

confidence: 99%