Impact of Powder Properties on the Rheological Behavior of Excipients

Janssen, Pauline H.M.; Depaifve, Sébastien; Neveu, A.; Francqui, Filip; Dickhoff, Bastiaan H.J.

doi:10.3390/pharmaceutics13081198

Cited by 19 publications

(9 citation statements)

References 39 publications

(60 reference statements)

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“…According to literature data, better flowability and compressibility can be obtained if the value of the Carr Index is smaller [50][51][52][53][54].…”

Section: Calcium Lactate Pharmacotechnical Propertiesmentioning

confidence: 99%

Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells

et al. 2022

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Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL®). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain.

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“…According to literature data, better flowability and compressibility can be obtained if the value of the Carr Index is smaller [50][51][52][53][54].…”

Section: Calcium Lactate Pharmacotechnical Propertiesmentioning

confidence: 99%

Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells

et al. 2022

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“…Considering all curves in Figure 9 , a fundamental behavior can be seen: the smaller the particle size, the worse the flow of the bulk material. This effect has been observed and discussed widely in the literature [ 82 , 108 , 109 , 110 , 111 , 112 ]. Furthermore, it was found that the smallest fraction <25 µm exhibits a significantly lower flowability for both materials.…”

Section: Properties Of Lunar Regolith Simulantsmentioning

confidence: 76%

Geotechnical and Shear Behavior of Novel Lunar Regolith Simulants TUBS-M, TUBS-T, and TUBS-I

et al. 2022

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The return to the Moon is an important short-term goal of NASA and other international space agencies. To minimize mission risks, technologies, such as rovers or regolith processing systems, must be developed and tested on Earth using lunar regolith simulants that closely resemble the properties of real lunar soil. So far, no singular lunar simulant can cover the multitude of use cases that lunar regolith involves, and most available materials are poorly characterized. To overcome this major gap, a unique modular system for flexible adaptable novel lunar regolith simulants was developed and chemically characterized in earlier works. To supplement this, the present study provides comprehensive investigations regarding geotechnical properties of the three base regolith simulant systems: TUBS-M, TUBS-T, and TUBS-I. To evaluate the engineering and flow properties of these heterogeneous materials under various conditions, shear tests, particle size analyses, scanning electron microscope observations, and density investigations were conducted. It was shown that small grains <25 µm (lunar dust) are highly compressive and cohesive even at low external stress. They are particularly important as a large amount of fine dust is present in lunar regolith and simulants (x50 = 76.7 to 96.0 µm). Further, ring shear and densification tests revealed correlations with damage mechanisms caused by local stress peaks for grains in the mm range. In addition, an explanation for the occurrence of considerable differences in the literature-based data for particle sizes was established by comparing various measurement procedures. The present study shows detailed geotechnical investigations of novel lunar regolith simulants, which can be used for the development of equipment for future lunar exploration missions and in situ resource utilization under realistic conditions. The results also provide evidence about possible correlations and causes of known soil-induced mission risks that so far have mostly been described phenomenologically.

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“…Based on the horizontal separation, formulations containing more cohesive fillers such as microcrystalline cellulose (MCC) were located at the right side of the cluster, while the well flowing and lower compressible fillers (e.g. 40LL, 22AN) were at the left side ( Van Snick et al, 2018b ; Janssen et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

Bekaert,

Janssen,

Fathollahi

et al. 2024

International Journal of Pharmaceutics: X

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Impact of Powder Properties on the Rheological Behavior of Excipients

Cited by 19 publications

References 39 publications

Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells

Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells

Geotechnical and Shear Behavior of Novel Lunar Regolith Simulants TUBS-M, TUBS-T, and TUBS-I

Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

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