Impact of Possibly Oncogenic High-Risk Human Papillomavirus (HPV) Types in Triage for ASC-US Cervical Cytology Results

Abstract

The inclusion of possibly oncogenic types in the HPV test panel led to an additional 51 colposcopy biopsies (33% increase), with no additional cases of CIN 2+. Our results suggest that including possibly oncogenic HPV types increases the number of colposcopy biopsies with minimal improvements in detection of CIN2 +.

Potential impact of introducing a nonavalent HPV vaccination

“…HPV is a DNA virus associated with precancerous conditions of the lower genital tract. Approximately 27 000 cases of HPV‐related cancers occur each year in the USA . More than 100 HPV types are known, and more than 40 types can be spread through sexual contact.…”

“…More than 100 HPV types are known, and more than 40 types can be spread through sexual contact. In particular, it is estimated that HPV16 and HPV18 are the most common HPV types involved in the genesis of genital cancers, being involved in more than 70% of cervical cancer …”

“…Approximately 27 000 cases of HPV-related cancers occur each year in the USA. 1,2 More than 100 HPV types are known, and more than 40 types can be spread through sexual contact.…”

“…In particular, it is estimated that HPV16 and HPV18 are the most common HPV types involved in the genesis of genital cancers, being involved in more than 70% of cervical cancer. 1,2 HPV vaccines can prevent the most common types of infections.…”