Impact of Porphyromonas gingivalis inoculation on ligature-induced alveolar bone loss. A pilot study in rats

Abstract

Within the limits of this pilot study, it was concluded that inoculation of P. gingivalis affected the ligature-induced ABL model by the induction of an anti-inflammatory and antiresorptive host response.

Periodontal and Systemic Responses in Various Mice Models of Experimental Periodontitis: Respective Roles of Inflammation Duration and Porphyromonas gingivalis Infection

“…These data show that the respective roles of inflammation and Pg infection in the local and systemic response to experimental periodontitis are not clearly defined 4,14 . The balance between Pg virulence and local and systemic responses influences the local and systemic effects of Pg infection.…”

Follicular dendritic cell‐secreted protein is decreased in experimental periodontitis concurrently with the increase of interleukin‐17 expression and the Rankl/Opg mRNA ratio

“…A significantly increased Rankl / Opg ratio and increased expression of Il17 mRNA has been reported in the presence of inflammatory bone resorption . Bezerra et al .…”

Protective Mechanisms of Simvastatin in Experimental Periodontal Disease

“…The ligature‐induced periodontitis model has been used extensively as a highly reproducible model that evaluates the progression of periodontal disease 14,18,22 . Some studies have demonstrated that this ligature model favors a heavier proinflammatory and proresorptive response, as demonstrated by increased IL‐1β/IL‐1ra, IL‐6/IL‐10, and RANKL/OPG ratios in the gingival tissues harvested from ligated sites versus non‐ligated sites 24 …”